Contribution of Tau Pathology to Mitochondrial Impairment in Neurodegeneration

Contribution of Tau Pathology to Mitochondrial Impairment in Neurodegeneration

Tau is an essential protein that physiologically promotes the assembly and stabilization of microtubules, and participates in neuronal development, axonal transport, and neuronal polarity. However, in a number of neurodegenerative diseases, including Alzheimer’s disease (AD), tau undergoes pathologi...

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Bibliographic Details
Main Authors: María J. Pérez, Claudia Jara, Rodrigo A. Quintanilla
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Neuroscience
Subjects:
tau
mitochondria
Alzheimer’s disease
synapse neurodegeneration
synapsis
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00441/full

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