Neurodegeneration, Heterochromatin, and Double-Stranded RNA
Changes in chromatin and epigenetic modifications have been associated with aging and aging-associated neurodegenerative diseases, although the causal relationship between these changes and disease-related pathology has been unclear. Recent studies have now made direct connections between neurodegen...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-02-01
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| Series: | Journal of Experimental Neuroscience |
| Online Access: | https://doi.org/10.1177/1179069519830697 |
| _version_ | 1818179775931351040 |
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| author | Tassa K Saldi Patrick K Gonzales Thomas J LaRocca Christopher D Link |
| author_facet | Tassa K Saldi Patrick K Gonzales Thomas J LaRocca Christopher D Link |
| author_sort | Tassa K Saldi |
| collection | DOAJ |
| description | Changes in chromatin and epigenetic modifications have been associated with aging and aging-associated neurodegenerative diseases, although the causal relationship between these changes and disease-related pathology has been unclear. Recent studies have now made direct connections between neurodegeneration-associated proteins and derepression of repetitive element transcription due to changes in heterochromatin. We suggest that this derepression leads to an increased accumulation of intracellular double-stranded RNA (dsRNA), with an attendant induction of innate immune responses that contribute to the neuroinflammation found in essentially all age-associated neurodegenerative diseases. |
| first_indexed | 2024-12-11T21:09:14Z |
| format | Article |
| id | doaj.art-d101bdd4f5e14be3b02e34f0c8b27413 |
| institution | Directory Open Access Journal |
| issn | 1179-0695 |
| language | English |
| last_indexed | 2024-12-11T21:09:14Z |
| publishDate | 2019-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Experimental Neuroscience |
| spelling | doaj.art-d101bdd4f5e14be3b02e34f0c8b274132022-12-22T00:50:46ZengSAGE PublishingJournal of Experimental Neuroscience1179-06952019-02-011310.1177/1179069519830697Neurodegeneration, Heterochromatin, and Double-Stranded RNATassa K Saldi0Patrick K Gonzales1Thomas J LaRocca2Christopher D Link3Department of Biochemistry and Molecular Genetics, University of Colorado, Aurora, CO, USADepartment of Integrative Physiology, University of Colorado, Boulder, CO, USADepartment of Integrative Physiology, University of Colorado, Boulder, CO, USADepartment of Integrative Physiology, University of Colorado, Boulder, CO, USAChanges in chromatin and epigenetic modifications have been associated with aging and aging-associated neurodegenerative diseases, although the causal relationship between these changes and disease-related pathology has been unclear. Recent studies have now made direct connections between neurodegeneration-associated proteins and derepression of repetitive element transcription due to changes in heterochromatin. We suggest that this derepression leads to an increased accumulation of intracellular double-stranded RNA (dsRNA), with an attendant induction of innate immune responses that contribute to the neuroinflammation found in essentially all age-associated neurodegenerative diseases.https://doi.org/10.1177/1179069519830697 |
| spellingShingle | Tassa K Saldi Patrick K Gonzales Thomas J LaRocca Christopher D Link Neurodegeneration, Heterochromatin, and Double-Stranded RNA Journal of Experimental Neuroscience |
| title | Neurodegeneration, Heterochromatin, and Double-Stranded RNA |
| title_full | Neurodegeneration, Heterochromatin, and Double-Stranded RNA |
| title_fullStr | Neurodegeneration, Heterochromatin, and Double-Stranded RNA |
| title_full_unstemmed | Neurodegeneration, Heterochromatin, and Double-Stranded RNA |
| title_short | Neurodegeneration, Heterochromatin, and Double-Stranded RNA |
| title_sort | neurodegeneration heterochromatin and double stranded rna |
| url | https://doi.org/10.1177/1179069519830697 |
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