Beetroot Extracts as Haematopoietic Agents on Rats
Introduction: Beetroot (Beta vulgaris L.) contains flavonoid compounds that play a role in the haematopoietic process. It is known that methanol extract of beetroot has benefits in the process of haematopoiesis in normal white rats. Aims: To evaluate the beetroots extracts as hematopoietic agents on...
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2021-05-01
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| Series: | Indonesian Journal of Pharmacy |
| Subjects: | |
| Online Access: | https://jurnal.ugm.ac.id/v3/IJP/article/view/1132 |
| _version_ | 1818406462741807104 |
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| author | Ni Putu Ermi Hikmawanti Lusi Putri Dwita Dinitia Az Zahra |
| author_facet | Ni Putu Ermi Hikmawanti Lusi Putri Dwita Dinitia Az Zahra |
| author_sort | Ni Putu Ermi Hikmawanti |
| collection | DOAJ |
| description | Introduction: Beetroot (Beta vulgaris L.) contains flavonoid compounds that play a role in the haematopoietic process. It is known that methanol extract of beetroot has benefits in the process of haematopoiesis in normal white rats. Aims: To evaluate the beetroots extracts as hematopoietic agents on male rats. Methods: Beetroots dried powder was divided into two parts. One part was macerated separately with dichloromethane and 70% ethanol, while the other part is added with citric acid and washed with water to remove alkaloids and then extracted with 70% ethanol. The study used 24 rats which were divided into four groups. Each group consisted of 6 rats, namely the normal group, dichloromethane extract group, ethanolic extract group, and free alkaloids-ethanolic extract group. Each extract was given at a dose of 200 mg.Kg-1 for 21 days. Analyzed blood parameters are erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets. The data obtained consisted of the number of cells analyzed using one-way ANOVA then obtained by the Tukey test. Results: This study showed a significant increase in the number of erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets in rats that were given each extract compared to the normal group (p <0.05). The ethanolic extract of beetroot can increase erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets by 41.49%, 24.95%, 14.92%, 33.54%, 27.19%, 59.40%, and 35.37%, respectively. Conclusions: The ethanolic extract of beetroot has the potential as a good natural haematopoietic agent. |
| first_indexed | 2024-12-14T09:12:20Z |
| format | Article |
| id | doaj.art-d1022198fd654b05ae5b5a2fdf8150d3 |
| institution | Directory Open Access Journal |
| issn | 2338-9427 2338-9486 |
| language | English |
| last_indexed | 2024-12-14T09:12:20Z |
| publishDate | 2021-05-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Pharmacy |
| spelling | doaj.art-d1022198fd654b05ae5b5a2fdf8150d32022-12-21T23:08:32ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862021-05-0117517810.22146/ijp.11321132Beetroot Extracts as Haematopoietic Agents on RatsNi Putu Ermi Hikmawanti0Lusi Putri Dwita1Dinitia Az Zahra2Department of Pharmaceutical Biology, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. HAMKA, 13460, East Jakarta, IndonesiaDepartment of Pharmacology, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. HAMKA, 13460, East Jakarta, IndonesiaFaculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. HAMKA, 13460, East Jakarta, IndonesiaIntroduction: Beetroot (Beta vulgaris L.) contains flavonoid compounds that play a role in the haematopoietic process. It is known that methanol extract of beetroot has benefits in the process of haematopoiesis in normal white rats. Aims: To evaluate the beetroots extracts as hematopoietic agents on male rats. Methods: Beetroots dried powder was divided into two parts. One part was macerated separately with dichloromethane and 70% ethanol, while the other part is added with citric acid and washed with water to remove alkaloids and then extracted with 70% ethanol. The study used 24 rats which were divided into four groups. Each group consisted of 6 rats, namely the normal group, dichloromethane extract group, ethanolic extract group, and free alkaloids-ethanolic extract group. Each extract was given at a dose of 200 mg.Kg-1 for 21 days. Analyzed blood parameters are erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets. The data obtained consisted of the number of cells analyzed using one-way ANOVA then obtained by the Tukey test. Results: This study showed a significant increase in the number of erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets in rats that were given each extract compared to the normal group (p <0.05). The ethanolic extract of beetroot can increase erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets by 41.49%, 24.95%, 14.92%, 33.54%, 27.19%, 59.40%, and 35.37%, respectively. Conclusions: The ethanolic extract of beetroot has the potential as a good natural haematopoietic agent.https://jurnal.ugm.ac.id/v3/IJP/article/view/1132beetroots, extract, haematopoietic |
| spellingShingle | Ni Putu Ermi Hikmawanti Lusi Putri Dwita Dinitia Az Zahra Beetroot Extracts as Haematopoietic Agents on Rats Indonesian Journal of Pharmacy beetroots, extract, haematopoietic |
| title | Beetroot Extracts as Haematopoietic Agents on Rats |
| title_full | Beetroot Extracts as Haematopoietic Agents on Rats |
| title_fullStr | Beetroot Extracts as Haematopoietic Agents on Rats |
| title_full_unstemmed | Beetroot Extracts as Haematopoietic Agents on Rats |
| title_short | Beetroot Extracts as Haematopoietic Agents on Rats |
| title_sort | beetroot extracts as haematopoietic agents on rats |
| topic | beetroots, extract, haematopoietic |
| url | https://jurnal.ugm.ac.id/v3/IJP/article/view/1132 |
| work_keys_str_mv | AT niputuermihikmawanti beetrootextractsashaematopoieticagentsonrats AT lusiputridwita beetrootextractsashaematopoieticagentsonrats AT dinitiaazzahra beetrootextractsashaematopoieticagentsonrats |