Behavioral Reserve in Behavioral Variant Frontotemporal Dementia
“Reserve” refers to the individual clinical differences in response to a neuropathological burden. We explored the behavioral reserve (BR) and associated neural substrates in 40 participants with behavioral variant frontotemporal dementia (bvFTD) who were assessed with the frontal behavioral invento...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.875589/full |
| _version_ | 1818253762914942976 |
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| author | Su Hong Kim Su Hong Kim Yae Ji Kim Yae Ji Kim Byung Hwa Lee Byung Hwa Lee Byung Hwa Lee Peter Lee Ji Hyung Park Sang Won Seo Sang Won Seo Sang Won Seo Sang Won Seo Sang Won Seo Yong Jeong Yong Jeong Yong Jeong Yong Jeong |
| author_facet | Su Hong Kim Su Hong Kim Yae Ji Kim Yae Ji Kim Byung Hwa Lee Byung Hwa Lee Byung Hwa Lee Peter Lee Ji Hyung Park Sang Won Seo Sang Won Seo Sang Won Seo Sang Won Seo Sang Won Seo Yong Jeong Yong Jeong Yong Jeong Yong Jeong |
| author_sort | Su Hong Kim |
| collection | DOAJ |
| description | “Reserve” refers to the individual clinical differences in response to a neuropathological burden. We explored the behavioral reserve (BR) and associated neural substrates in 40 participants with behavioral variant frontotemporal dementia (bvFTD) who were assessed with the frontal behavioral inventory (FBI) and magnetic resonance imaging. Because neuroimaging abnormality showed a high negative correlation with the FBI negative (but not positive) symptom scores, we developed a linear model only to calculate the nBR (BR for negative symptoms) marker using neuroimaging abnormalities and the FBI score. Participants were divided into high nBR and low nBR groups based on the nBR marker. The FBI negative symptom score was lower in the high nBR group than in the low nBR group having the same neuroimaging abnormalities. However, the high nBR group noted a steeper decline in cortical atrophy and showed less atrophy in the left frontotemporal cortices than the low nBR group. In addition, the fractional anisotropy (FA) values were greater in the high nBR than in the low nBR group, except in the sensory-motor and occipital areas. We identified an nBR-related functional network composed of bilateral frontotemporal areas and the left occipital pole. We propose the concept of BR in bvFTD, and these findings can help predict the disease progression. |
| first_indexed | 2024-12-12T16:45:14Z |
| format | Article |
| id | doaj.art-d102df65b97b435fb460b61e3df1d6e7 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-12T16:45:14Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-d102df65b97b435fb460b61e3df1d6e72022-12-22T00:18:30ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-06-011410.3389/fnagi.2022.875589875589Behavioral Reserve in Behavioral Variant Frontotemporal DementiaSu Hong Kim0Su Hong Kim1Yae Ji Kim2Yae Ji Kim3Byung Hwa Lee4Byung Hwa Lee5Byung Hwa Lee6Peter Lee7Ji Hyung Park8Sang Won Seo9Sang Won Seo10Sang Won Seo11Sang Won Seo12Sang Won Seo13Yong Jeong14Yong Jeong15Yong Jeong16Yong Jeong17Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South KoreaKAIST Institute for Health Science Technology, Korea Advanced Institute of Science and Technology, Daejeon, South KoreaKAIST Institute for Health Science Technology, Korea Advanced Institute of Science and Technology, Daejeon, South KoreaProgram of Brain and Cognitive Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University, Seoul, South KoreaNeuroscience Center, Samsung Medical Center, Seoul, South KoreaSamsung Alzheimer Research Center, Samsung Medical Center, Seoul, South KoreaKAIST Institute for Health Science Technology, Korea Advanced Institute of Science and Technology, Daejeon, South KoreaGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University, Seoul, South KoreaNeuroscience Center, Samsung Medical Center, Seoul, South KoreaSamsung Alzheimer Research Center, Samsung Medical Center, Seoul, South KoreaDepartment of Health Science and Technology, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Seoul, South KoreaDepartment of Intelligent Precision Healthcare Convergence, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Seoul, South KoreaGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South KoreaKAIST Institute for Health Science Technology, Korea Advanced Institute of Science and Technology, Daejeon, South KoreaProgram of Brain and Cognitive Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South KoreaDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea“Reserve” refers to the individual clinical differences in response to a neuropathological burden. We explored the behavioral reserve (BR) and associated neural substrates in 40 participants with behavioral variant frontotemporal dementia (bvFTD) who were assessed with the frontal behavioral inventory (FBI) and magnetic resonance imaging. Because neuroimaging abnormality showed a high negative correlation with the FBI negative (but not positive) symptom scores, we developed a linear model only to calculate the nBR (BR for negative symptoms) marker using neuroimaging abnormalities and the FBI score. Participants were divided into high nBR and low nBR groups based on the nBR marker. The FBI negative symptom score was lower in the high nBR group than in the low nBR group having the same neuroimaging abnormalities. However, the high nBR group noted a steeper decline in cortical atrophy and showed less atrophy in the left frontotemporal cortices than the low nBR group. In addition, the fractional anisotropy (FA) values were greater in the high nBR than in the low nBR group, except in the sensory-motor and occipital areas. We identified an nBR-related functional network composed of bilateral frontotemporal areas and the left occipital pole. We propose the concept of BR in bvFTD, and these findings can help predict the disease progression.https://www.frontiersin.org/articles/10.3389/fnagi.2022.875589/fullbehavioral variant frontotemporal dementiabehavior reserveneural correlatesbrain networkMRI |
| spellingShingle | Su Hong Kim Su Hong Kim Yae Ji Kim Yae Ji Kim Byung Hwa Lee Byung Hwa Lee Byung Hwa Lee Peter Lee Ji Hyung Park Sang Won Seo Sang Won Seo Sang Won Seo Sang Won Seo Sang Won Seo Yong Jeong Yong Jeong Yong Jeong Yong Jeong Behavioral Reserve in Behavioral Variant Frontotemporal Dementia Frontiers in Aging Neuroscience behavioral variant frontotemporal dementia behavior reserve neural correlates brain network MRI |
| title | Behavioral Reserve in Behavioral Variant Frontotemporal Dementia |
| title_full | Behavioral Reserve in Behavioral Variant Frontotemporal Dementia |
| title_fullStr | Behavioral Reserve in Behavioral Variant Frontotemporal Dementia |
| title_full_unstemmed | Behavioral Reserve in Behavioral Variant Frontotemporal Dementia |
| title_short | Behavioral Reserve in Behavioral Variant Frontotemporal Dementia |
| title_sort | behavioral reserve in behavioral variant frontotemporal dementia |
| topic | behavioral variant frontotemporal dementia behavior reserve neural correlates brain network MRI |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.875589/full |
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