A Systematic Evaluation of High-Throughput Sequencing Approaches to Identify Low-Frequency Single Nucleotide Variants in Viral Populations
High-throughput sequencing such as those provided by Illumina are an efficient way to understand sequence variation within viral populations. However, challenges exist in distinguishing process-introduced error from biological variance, which significantly impacts our ability to identify sub-consens...
Main Authors: | David J. King, Graham Freimanis, Lidia Lasecka-Dykes, Amin Asfor, Paolo Ribeca, Ryan Waters, Donald P. King, Emma Laing |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-10-01
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Series: | Viruses |
Subjects: | |
Online Access: | https://www.mdpi.com/1999-4915/12/10/1187 |
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