A Brief Overview of Neutrophils in Neurological Diseases
Neutrophils are the most abundant leukocyte in circulation and are the first line of defense after an infection or injury. Neutrophils have a broad spectrum of functions, including phagocytosis of microorganisms, the release of pro-inflammatory cytokines and chemokines, oxidative burst, and the form...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/13/5/743 |
| _version_ | 1797600957879549952 |
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| author | Supriya Chakraborty Zeynab Tabrizi Nairuti Nikhil Bhatt Sofia Andrea Franciosa Oliver Bracko |
| author_facet | Supriya Chakraborty Zeynab Tabrizi Nairuti Nikhil Bhatt Sofia Andrea Franciosa Oliver Bracko |
| author_sort | Supriya Chakraborty |
| collection | DOAJ |
| description | Neutrophils are the most abundant leukocyte in circulation and are the first line of defense after an infection or injury. Neutrophils have a broad spectrum of functions, including phagocytosis of microorganisms, the release of pro-inflammatory cytokines and chemokines, oxidative burst, and the formation of neutrophil extracellular traps. Traditionally, neutrophils were thought to be most important for acute inflammatory responses, with a short half-life and a more static response to infections and injury. However, this view has changed in recent years showing neutrophil heterogeneity and dynamics, indicating a much more regulated and flexible response. Here we will discuss the role of neutrophils in aging and neurological disorders; specifically, we focus on recent data indicating the impact of neutrophils in chronic inflammatory processes and their contribution to neurological diseases. Lastly, we aim to conclude that reactive neutrophils directly contribute to increased vascular inflammation and age-related diseases. |
| first_indexed | 2024-03-11T03:55:09Z |
| format | Article |
| id | doaj.art-d1037135018b4f039544c5f7d2510ce6 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T03:55:09Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-d1037135018b4f039544c5f7d2510ce62023-11-18T00:38:30ZengMDPI AGBiomolecules2218-273X2023-04-0113574310.3390/biom13050743A Brief Overview of Neutrophils in Neurological DiseasesSupriya Chakraborty0Zeynab Tabrizi1Nairuti Nikhil Bhatt2Sofia Andrea Franciosa3Oliver Bracko4Department of Biology, University of Miami, Coral Gables, FL 33146, USADepartment of Biology, University of Miami, Coral Gables, FL 33146, USADepartment of Biology, University of Miami, Coral Gables, FL 33146, USADepartment of Biology, University of Miami, Coral Gables, FL 33146, USADepartment of Biology, University of Miami, Coral Gables, FL 33146, USANeutrophils are the most abundant leukocyte in circulation and are the first line of defense after an infection or injury. Neutrophils have a broad spectrum of functions, including phagocytosis of microorganisms, the release of pro-inflammatory cytokines and chemokines, oxidative burst, and the formation of neutrophil extracellular traps. Traditionally, neutrophils were thought to be most important for acute inflammatory responses, with a short half-life and a more static response to infections and injury. However, this view has changed in recent years showing neutrophil heterogeneity and dynamics, indicating a much more regulated and flexible response. Here we will discuss the role of neutrophils in aging and neurological disorders; specifically, we focus on recent data indicating the impact of neutrophils in chronic inflammatory processes and their contribution to neurological diseases. Lastly, we aim to conclude that reactive neutrophils directly contribute to increased vascular inflammation and age-related diseases.https://www.mdpi.com/2218-273X/13/5/743neutrophilsNETosisvascular inflammationneutrophil heterogeneity |
| spellingShingle | Supriya Chakraborty Zeynab Tabrizi Nairuti Nikhil Bhatt Sofia Andrea Franciosa Oliver Bracko A Brief Overview of Neutrophils in Neurological Diseases Biomolecules neutrophils NETosis vascular inflammation neutrophil heterogeneity |
| title | A Brief Overview of Neutrophils in Neurological Diseases |
| title_full | A Brief Overview of Neutrophils in Neurological Diseases |
| title_fullStr | A Brief Overview of Neutrophils in Neurological Diseases |
| title_full_unstemmed | A Brief Overview of Neutrophils in Neurological Diseases |
| title_short | A Brief Overview of Neutrophils in Neurological Diseases |
| title_sort | brief overview of neutrophils in neurological diseases |
| topic | neutrophils NETosis vascular inflammation neutrophil heterogeneity |
| url | https://www.mdpi.com/2218-273X/13/5/743 |
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