Immunohistochemical study of osteopontin, Ki-67, and CD34 of psoriasis in Mansoura, Egypt
Background and Objective: Psoriasis is a chronic inflammatory skin disease characterized by hyper-proliferation, abnormal differentiation, and inflammatory infiltration in epidermis and dermis. We planned this study to analyze probable associations between Osteopontin (OPN), Ki-67, CD34, and histopa...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2012;volume=55;issue=1;spage=56;epage=60;aulast=Amin |
| _version_ | 1818891189415313408 |
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| author | Maha Mohamed Amin Zeinab Abdel Azim |
| author_facet | Maha Mohamed Amin Zeinab Abdel Azim |
| author_sort | Maha Mohamed Amin |
| collection | DOAJ |
| description | Background and Objective: Psoriasis is a chronic inflammatory skin disease characterized by hyper-proliferation, abnormal differentiation, and inflammatory infiltration in epidermis and dermis. We planned this study to analyze probable associations between Osteopontin (OPN), Ki-67, CD34, and histopathological features in psoriasis. Materials and Methods: We studied OPN expression and its correlation with Ki-67 and CD34 expression in lesional, non-lesional skin, and normal skin. Immunoreactivity for OPN and Ki-67 was based on the level of epidermal staining. CD34 expression was scored as mild, moderate, and strong, according to the number of stained dermal capillaries. Results: Our results showed statistically significant differences in the expression of OPN, Ki-67, and CD34 between lesional and non-lesional skin as well as between non-lesional skin and control group (P≤0.001). In addition, there was a significant difference in the expression of OPN, Ki-67, and CD34 between control and lesional group (P=0.02, P=0.02, and P=0.04, respectively). Conclusions: OPN expression seems to be related to Ki-67 (proliferation index) and CD34 expression (angiogenesis marker) confirming its role in the pathogenesis of psoriasis. Then "anti- OPN and anti-angiogenesis" may eventually become a useful therapeutic approach in psoriasis. |
| first_indexed | 2024-12-19T17:36:51Z |
| format | Article |
| id | doaj.art-d103bcd03de34f8388fc92ad2f4fc87a |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-19T17:36:51Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-d103bcd03de34f8388fc92ad2f4fc87a2022-12-21T20:12:18ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292012-01-01551566010.4103/0377-4929.94857Immunohistochemical study of osteopontin, Ki-67, and CD34 of psoriasis in Mansoura, EgyptMaha Mohamed AminZeinab Abdel AzimBackground and Objective: Psoriasis is a chronic inflammatory skin disease characterized by hyper-proliferation, abnormal differentiation, and inflammatory infiltration in epidermis and dermis. We planned this study to analyze probable associations between Osteopontin (OPN), Ki-67, CD34, and histopathological features in psoriasis. Materials and Methods: We studied OPN expression and its correlation with Ki-67 and CD34 expression in lesional, non-lesional skin, and normal skin. Immunoreactivity for OPN and Ki-67 was based on the level of epidermal staining. CD34 expression was scored as mild, moderate, and strong, according to the number of stained dermal capillaries. Results: Our results showed statistically significant differences in the expression of OPN, Ki-67, and CD34 between lesional and non-lesional skin as well as between non-lesional skin and control group (P≤0.001). In addition, there was a significant difference in the expression of OPN, Ki-67, and CD34 between control and lesional group (P=0.02, P=0.02, and P=0.04, respectively). Conclusions: OPN expression seems to be related to Ki-67 (proliferation index) and CD34 expression (angiogenesis marker) confirming its role in the pathogenesis of psoriasis. Then "anti- OPN and anti-angiogenesis" may eventually become a useful therapeutic approach in psoriasis.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2012;volume=55;issue=1;spage=56;epage=60;aulast=AminCD34Ki-67osteopontinpsoriasis |
| spellingShingle | Maha Mohamed Amin Zeinab Abdel Azim Immunohistochemical study of osteopontin, Ki-67, and CD34 of psoriasis in Mansoura, Egypt Indian Journal of Pathology and Microbiology CD34 Ki-67 osteopontin psoriasis |
| title | Immunohistochemical study of osteopontin, Ki-67, and CD34 of psoriasis in Mansoura, Egypt |
| title_full | Immunohistochemical study of osteopontin, Ki-67, and CD34 of psoriasis in Mansoura, Egypt |
| title_fullStr | Immunohistochemical study of osteopontin, Ki-67, and CD34 of psoriasis in Mansoura, Egypt |
| title_full_unstemmed | Immunohistochemical study of osteopontin, Ki-67, and CD34 of psoriasis in Mansoura, Egypt |
| title_short | Immunohistochemical study of osteopontin, Ki-67, and CD34 of psoriasis in Mansoura, Egypt |
| title_sort | immunohistochemical study of osteopontin ki 67 and cd34 of psoriasis in mansoura egypt |
| topic | CD34 Ki-67 osteopontin psoriasis |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2012;volume=55;issue=1;spage=56;epage=60;aulast=Amin |
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