Prognostic value of measurement of myocardial extracellular volume using dual-energy CT in heart failure with preserved ejection fraction
Abstract Diffuse myocardial fibrosis is associated with adverse outcomes in heart failure with preserved ejection fraction (HFpEF). Dual-energy CT (DECT) can noninvasively assess myocardial fibrosis by quantification of extracellular volume (ECV) fraction. This study evaluated the association betwee...
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-58271-9 |
| _version_ | 1797233700218339328 |
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| author | Ying Jiang Jiaqi Ye Yang Yang Ying Zhang Xiaoyun Yan Wenhui Qiang Haixiao Chen Shuang Xu Lei Zhou Rongxing Qi Qing Zhang |
| author_facet | Ying Jiang Jiaqi Ye Yang Yang Ying Zhang Xiaoyun Yan Wenhui Qiang Haixiao Chen Shuang Xu Lei Zhou Rongxing Qi Qing Zhang |
| author_sort | Ying Jiang |
| collection | DOAJ |
| description | Abstract Diffuse myocardial fibrosis is associated with adverse outcomes in heart failure with preserved ejection fraction (HFpEF). Dual-energy CT (DECT) can noninvasively assess myocardial fibrosis by quantification of extracellular volume (ECV) fraction. This study evaluated the association between ECV measured by DECT and clinical outcomes in patients with HFpEF. 125 hospitalized HFpEF patients were enrolled in this retrospective cohort study. ECV was measured using DECT with late iodine enhancement. The composite endpoint was defined as HFpEF hospitalization and all-cause mortality during the follow-up. During the median follow-up of 10.4 months, 34 patients (27.20%) experienced the composite outcomes, including 5 deaths; and 29 HFpEF hospitalizations. The higher DECT-ECV group had higher rates of composite outcomes than the low ECV group (log-rank X 2 = 6.818, P = 0.033). In multivariate Cox regression analysis, the ECV (HR 1.17, 95% CI 1.06–1.30, P = 0.001) and NT-pro BNP (HR 2.83, 95% CI 1.16–6.88, P = 0.022) were independent risk factors for the adverse outcomes. Myocardial ECV measured using DECT was an independent risk factor for adverse outcomes in patients with HFpEF. |
| first_indexed | 2024-04-24T16:20:20Z |
| format | Article |
| id | doaj.art-d1050686ebb24895804cc1f025181e75 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T16:20:20Z |
| publishDate | 2024-03-01 |
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| spelling | doaj.art-d1050686ebb24895804cc1f025181e752024-03-31T11:16:30ZengNature PortfolioScientific Reports2045-23222024-03-011411910.1038/s41598-024-58271-9Prognostic value of measurement of myocardial extracellular volume using dual-energy CT in heart failure with preserved ejection fractionYing Jiang0Jiaqi Ye1Yang Yang2Ying Zhang3Xiaoyun Yan4Wenhui Qiang5Haixiao Chen6Shuang Xu7Lei Zhou8Rongxing Qi9Qing Zhang10Department of General Practice, The Second Affiliated Hospital of Nantong UniversityDepartment of General Practice, The Second Affiliated Hospital of Nantong UniversityDepartment of General Practice, The Second Affiliated Hospital of Nantong UniversityDepartment of General Practice, The Second Affiliated Hospital of Nantong UniversityDepartment of General Practice, The Second Affiliated Hospital of Nantong UniversityDepartment of General Practice, The Second Affiliated Hospital of Nantong UniversityDepartment of General Practice, The Second Affiliated Hospital of Nantong UniversityDepartment of General Practice, The Second Affiliated Hospital of Nantong UniversityDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Radiology, The Second Affiliated Hospital of Nantong UniversityDepartment of General Practice, The Second Affiliated Hospital of Nantong UniversityAbstract Diffuse myocardial fibrosis is associated with adverse outcomes in heart failure with preserved ejection fraction (HFpEF). Dual-energy CT (DECT) can noninvasively assess myocardial fibrosis by quantification of extracellular volume (ECV) fraction. This study evaluated the association between ECV measured by DECT and clinical outcomes in patients with HFpEF. 125 hospitalized HFpEF patients were enrolled in this retrospective cohort study. ECV was measured using DECT with late iodine enhancement. The composite endpoint was defined as HFpEF hospitalization and all-cause mortality during the follow-up. During the median follow-up of 10.4 months, 34 patients (27.20%) experienced the composite outcomes, including 5 deaths; and 29 HFpEF hospitalizations. The higher DECT-ECV group had higher rates of composite outcomes than the low ECV group (log-rank X 2 = 6.818, P = 0.033). In multivariate Cox regression analysis, the ECV (HR 1.17, 95% CI 1.06–1.30, P = 0.001) and NT-pro BNP (HR 2.83, 95% CI 1.16–6.88, P = 0.022) were independent risk factors for the adverse outcomes. Myocardial ECV measured using DECT was an independent risk factor for adverse outcomes in patients with HFpEF.https://doi.org/10.1038/s41598-024-58271-9 |
| spellingShingle | Ying Jiang Jiaqi Ye Yang Yang Ying Zhang Xiaoyun Yan Wenhui Qiang Haixiao Chen Shuang Xu Lei Zhou Rongxing Qi Qing Zhang Prognostic value of measurement of myocardial extracellular volume using dual-energy CT in heart failure with preserved ejection fraction Scientific Reports |
| title | Prognostic value of measurement of myocardial extracellular volume using dual-energy CT in heart failure with preserved ejection fraction |
| title_full | Prognostic value of measurement of myocardial extracellular volume using dual-energy CT in heart failure with preserved ejection fraction |
| title_fullStr | Prognostic value of measurement of myocardial extracellular volume using dual-energy CT in heart failure with preserved ejection fraction |
| title_full_unstemmed | Prognostic value of measurement of myocardial extracellular volume using dual-energy CT in heart failure with preserved ejection fraction |
| title_short | Prognostic value of measurement of myocardial extracellular volume using dual-energy CT in heart failure with preserved ejection fraction |
| title_sort | prognostic value of measurement of myocardial extracellular volume using dual energy ct in heart failure with preserved ejection fraction |
| url | https://doi.org/10.1038/s41598-024-58271-9 |
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