Isthmectomy is effective and sufficient for selected patients with the isthmus-confined solitary papillary thyroid carcinoma
Background: To retrospectively analyze the outcomes of patients treated with isthmusectomy for a solitary papillary thyroid carcinoma (PTC) confined to the isthmus, and re-assess the role of isthmusectomy in these patients. Methods: The medical records of 65 patients who underwent isthmusectomy for...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Asian Journal of Surgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958422000628 |
| _version_ | 1828778308582506496 |
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| author | Hui Huang Dangui Yan Wensheng Liu Shaoyan Liu Zhengang Xu Xiaolei Wang |
| author_facet | Hui Huang Dangui Yan Wensheng Liu Shaoyan Liu Zhengang Xu Xiaolei Wang |
| author_sort | Hui Huang |
| collection | DOAJ |
| description | Background: To retrospectively analyze the outcomes of patients treated with isthmusectomy for a solitary papillary thyroid carcinoma (PTC) confined to the isthmus, and re-assess the role of isthmusectomy in these patients. Methods: The medical records of 65 patients who underwent isthmusectomy for a solitary PTC confined to the isthmus at the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College between 1985 and 2015 were retrospectively reviewed. Demographic data, surgical procedures, pathological characteristics, stages, and outcomes were analyzed. Results: Patients’ median age was 39 years (range, 19–63), and the majority were female (86.2% female, 13.8% male). All patients had a solitary PTC confined to the isthmus and were treated with isthmusectomy. Pretracheal lymph node dissection was performed in 34 patients, in which unilateral central neck dissection was performed in 4 patients and bilateral central neck dissection in 2 patients. Microscopic extrathyroidal extension (ETE) was observed in 23 (35.4%) patients, and macroscopic ETE was observed in 3 (4.6%) patients. Thirty-eight (58.5%) patients were stage pT1a, 19 (29.2%) patients were stage pT1b, 5 (7.7%) patients were stage pT2, and 3 (4.6%) patients were stage p3b. Fifteen (23.1%) patients were stage pN1a. Median follow-up time was 78 months (range, 12–274). Two patients experienced a recurrence and both achieved remission after re-operation. The 10-year recurrence-free survival was 92.1%. The 10-year overall survival and disease specific survival were 98.3% and 100%, respectively. Conclusions: Isthmusectomy is effective and sufficient for select patients with a solitary PTC confined to the isthmus. |
| first_indexed | 2024-12-11T16:38:23Z |
| format | Article |
| id | doaj.art-d1056da18d584395ac0f13bc11a6c6f9 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-12-11T16:38:23Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-d1056da18d584395ac0f13bc11a6c6f92022-12-22T00:58:23ZengElsevierAsian Journal of Surgery1015-95842022-09-0145916781681Isthmectomy is effective and sufficient for selected patients with the isthmus-confined solitary papillary thyroid carcinomaHui Huang0Dangui Yan1Wensheng Liu2Shaoyan Liu3Zhengang Xu4Xiaolei Wang5Department of Head and Neck Surgery, National Cancer Center /National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaDepartment of Head and Neck Surgery, National Cancer Center /National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaDepartment of Head and Neck Surgery, National Cancer Center /National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaDepartment of Head and Neck Surgery, National Cancer Center /National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaDepartment of Head and Neck Surgery, National Cancer Center /National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaCorresponding author. Department of Head and Neck Surgery, National Cancer Center /National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, N0.17 Panjiayuan Road, Beijing, China.; Department of Head and Neck Surgery, National Cancer Center /National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaBackground: To retrospectively analyze the outcomes of patients treated with isthmusectomy for a solitary papillary thyroid carcinoma (PTC) confined to the isthmus, and re-assess the role of isthmusectomy in these patients. Methods: The medical records of 65 patients who underwent isthmusectomy for a solitary PTC confined to the isthmus at the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College between 1985 and 2015 were retrospectively reviewed. Demographic data, surgical procedures, pathological characteristics, stages, and outcomes were analyzed. Results: Patients’ median age was 39 years (range, 19–63), and the majority were female (86.2% female, 13.8% male). All patients had a solitary PTC confined to the isthmus and were treated with isthmusectomy. Pretracheal lymph node dissection was performed in 34 patients, in which unilateral central neck dissection was performed in 4 patients and bilateral central neck dissection in 2 patients. Microscopic extrathyroidal extension (ETE) was observed in 23 (35.4%) patients, and macroscopic ETE was observed in 3 (4.6%) patients. Thirty-eight (58.5%) patients were stage pT1a, 19 (29.2%) patients were stage pT1b, 5 (7.7%) patients were stage pT2, and 3 (4.6%) patients were stage p3b. Fifteen (23.1%) patients were stage pN1a. Median follow-up time was 78 months (range, 12–274). Two patients experienced a recurrence and both achieved remission after re-operation. The 10-year recurrence-free survival was 92.1%. The 10-year overall survival and disease specific survival were 98.3% and 100%, respectively. Conclusions: Isthmusectomy is effective and sufficient for select patients with a solitary PTC confined to the isthmus.http://www.sciencedirect.com/science/article/pii/S1015958422000628Thyroid tumorThyroid isthmusPapillary carcinomaThyroid isthmusectomy |
| spellingShingle | Hui Huang Dangui Yan Wensheng Liu Shaoyan Liu Zhengang Xu Xiaolei Wang Isthmectomy is effective and sufficient for selected patients with the isthmus-confined solitary papillary thyroid carcinoma Asian Journal of Surgery Thyroid tumor Thyroid isthmus Papillary carcinoma Thyroid isthmusectomy |
| title | Isthmectomy is effective and sufficient for selected patients with the isthmus-confined solitary papillary thyroid carcinoma |
| title_full | Isthmectomy is effective and sufficient for selected patients with the isthmus-confined solitary papillary thyroid carcinoma |
| title_fullStr | Isthmectomy is effective and sufficient for selected patients with the isthmus-confined solitary papillary thyroid carcinoma |
| title_full_unstemmed | Isthmectomy is effective and sufficient for selected patients with the isthmus-confined solitary papillary thyroid carcinoma |
| title_short | Isthmectomy is effective and sufficient for selected patients with the isthmus-confined solitary papillary thyroid carcinoma |
| title_sort | isthmectomy is effective and sufficient for selected patients with the isthmus confined solitary papillary thyroid carcinoma |
| topic | Thyroid tumor Thyroid isthmus Papillary carcinoma Thyroid isthmusectomy |
| url | http://www.sciencedirect.com/science/article/pii/S1015958422000628 |
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