Early Events in Japanese Encephalitis Virus Infection: Viral Entry
Japanese encephalitis virus (JEV), a mosquito-borne zoonotic flavivirus, is an enveloped positive-strand RNA virus that can cause a spectrum of clinical manifestations, ranging from mild febrile illness to severe neuroinvasive disease. Today, several killed and live vaccines are available in differe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-08-01
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| Series: | Pathogens |
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| Online Access: | http://www.mdpi.com/2076-0817/7/3/68 |
| _version_ | 1798041954710192128 |
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| author | Sang-Im Yun Young-Min Lee |
| author_facet | Sang-Im Yun Young-Min Lee |
| author_sort | Sang-Im Yun |
| collection | DOAJ |
| description | Japanese encephalitis virus (JEV), a mosquito-borne zoonotic flavivirus, is an enveloped positive-strand RNA virus that can cause a spectrum of clinical manifestations, ranging from mild febrile illness to severe neuroinvasive disease. Today, several killed and live vaccines are available in different parts of the globe for use in humans to prevent JEV-induced diseases, yet no antivirals are available to treat JEV-associated diseases. Despite the progress made in vaccine research and development, JEV is still a major public health problem in southern, eastern, and southeastern Asia, as well as northern Oceania, with the potential to become an emerging global pathogen. In viral replication, the entry of JEV into the cell is the first step in a cascade of complex interactions between the virus and target cells that is required for the initiation, dissemination, and maintenance of infection. Because this step determines cell/tissue tropism and pathogenesis, it is a promising target for antiviral therapy. JEV entry is mediated by the viral glycoprotein E, which binds virions to the cell surface (attachment), delivers them to endosomes (endocytosis), and catalyzes the fusion between the viral and endosomal membranes (membrane fusion), followed by the release of the viral genome into the cytoplasm (uncoating). In this multistep process, a collection of host factors are involved. In this review, we summarize the current knowledge on the viral and cellular components involved in JEV entry into host cells, with an emphasis on the initial virus-host cell interactions on the cell surface. |
| first_indexed | 2024-04-11T22:28:46Z |
| format | Article |
| id | doaj.art-d106b145b5224bfb81f78e9b2e7f8971 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-04-11T22:28:46Z |
| publishDate | 2018-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-d106b145b5224bfb81f78e9b2e7f89712022-12-22T03:59:34ZengMDPI AGPathogens2076-08172018-08-01736810.3390/pathogens7030068pathogens7030068Early Events in Japanese Encephalitis Virus Infection: Viral EntrySang-Im Yun0Young-Min Lee1Department of Animal, Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences, Utah State University, Logan, UT 84322, USADepartment of Animal, Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences, Utah State University, Logan, UT 84322, USAJapanese encephalitis virus (JEV), a mosquito-borne zoonotic flavivirus, is an enveloped positive-strand RNA virus that can cause a spectrum of clinical manifestations, ranging from mild febrile illness to severe neuroinvasive disease. Today, several killed and live vaccines are available in different parts of the globe for use in humans to prevent JEV-induced diseases, yet no antivirals are available to treat JEV-associated diseases. Despite the progress made in vaccine research and development, JEV is still a major public health problem in southern, eastern, and southeastern Asia, as well as northern Oceania, with the potential to become an emerging global pathogen. In viral replication, the entry of JEV into the cell is the first step in a cascade of complex interactions between the virus and target cells that is required for the initiation, dissemination, and maintenance of infection. Because this step determines cell/tissue tropism and pathogenesis, it is a promising target for antiviral therapy. JEV entry is mediated by the viral glycoprotein E, which binds virions to the cell surface (attachment), delivers them to endosomes (endocytosis), and catalyzes the fusion between the viral and endosomal membranes (membrane fusion), followed by the release of the viral genome into the cytoplasm (uncoating). In this multistep process, a collection of host factors are involved. In this review, we summarize the current knowledge on the viral and cellular components involved in JEV entry into host cells, with an emphasis on the initial virus-host cell interactions on the cell surface.http://www.mdpi.com/2076-0817/7/3/68Japanese encephalitis virusflavivirusviral replicationviral entryattachmentbindingendocytosisinternalizationmembrane fusionvirus-host interaction |
| spellingShingle | Sang-Im Yun Young-Min Lee Early Events in Japanese Encephalitis Virus Infection: Viral Entry Pathogens Japanese encephalitis virus flavivirus viral replication viral entry attachment binding endocytosis internalization membrane fusion virus-host interaction |
| title | Early Events in Japanese Encephalitis Virus Infection: Viral Entry |
| title_full | Early Events in Japanese Encephalitis Virus Infection: Viral Entry |
| title_fullStr | Early Events in Japanese Encephalitis Virus Infection: Viral Entry |
| title_full_unstemmed | Early Events in Japanese Encephalitis Virus Infection: Viral Entry |
| title_short | Early Events in Japanese Encephalitis Virus Infection: Viral Entry |
| title_sort | early events in japanese encephalitis virus infection viral entry |
| topic | Japanese encephalitis virus flavivirus viral replication viral entry attachment binding endocytosis internalization membrane fusion virus-host interaction |
| url | http://www.mdpi.com/2076-0817/7/3/68 |
| work_keys_str_mv | AT sangimyun earlyeventsinjapaneseencephalitisvirusinfectionviralentry AT youngminlee earlyeventsinjapaneseencephalitisvirusinfectionviralentry |