Trends in the Epidemiological and Clinical Profile of Paracoccidioidomycosis in the Endemic Area of Rio de Janeiro, Brazil
Paracoccidioidomycosis (PCM) is a neglected endemic mycosis in Latin America. Most cases occur in Brazil. It is classified as PCM infection and PCM disease and is subdivided into chronic (adult type) or acute (juvenile type) disease, with the latter being less frequent and more severe. In 2016, we r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/9/9/946 |
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| author | Eduardo Mastrangelo Marinho Falcão Dayvison Francis Saraiva Freitas Ziadir Francisco Coutinho Leonardo Pereira Quintella Mauro de Medeiros Muniz Rodrigo Almeida-Paes Rosely Maria Zancopé-Oliveira Priscila Marques de Macedo Antonio Carlos Francesconi do Valle |
| author_facet | Eduardo Mastrangelo Marinho Falcão Dayvison Francis Saraiva Freitas Ziadir Francisco Coutinho Leonardo Pereira Quintella Mauro de Medeiros Muniz Rodrigo Almeida-Paes Rosely Maria Zancopé-Oliveira Priscila Marques de Macedo Antonio Carlos Francesconi do Valle |
| author_sort | Eduardo Mastrangelo Marinho Falcão |
| collection | DOAJ |
| description | Paracoccidioidomycosis (PCM) is a neglected endemic mycosis in Latin America. Most cases occur in Brazil. It is classified as PCM infection and PCM disease and is subdivided into chronic (adult type) or acute (juvenile type) disease, with the latter being less frequent and more severe. In 2016, we reported an increase in the numbers of patients diagnosed with acute PCM after a highway’s construction. We conducted a study at INI-Fiocruz, a reference center for infectious diseases, including endemic mycoses, in Rio de Janeiro, Brazil, aiming to deepen the analysis of this new clinical and epidemiological profile of PCM. The authors developed a retrospective study including 170 patients diagnosed with PCM between 2010 and 2019. There was an increase in the number of atypical and severe forms, starting in 2014. In subsequent years, we detected a higher incidence of adverse outcomes with patients requiring more hospitalizations and an increased mortality rate. We estimate that PCM has become more severe throughout the Rio de Janeiro state, affecting a greater number of young individuals and leading to a greater number of and longer hospitalizations. Surveillance measures and close monitoring of future notification data in the state, with emphasis on children, adolescents, and young adults are necessary for a better understanding of the perpetuation of this public health challenge. |
| first_indexed | 2024-03-10T22:35:33Z |
| format | Article |
| id | doaj.art-d1078bc7db3948d48a43cc0f368ee060 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T22:35:33Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-d1078bc7db3948d48a43cc0f368ee0602023-11-19T11:29:30ZengMDPI AGJournal of Fungi2309-608X2023-09-019994610.3390/jof9090946Trends in the Epidemiological and Clinical Profile of Paracoccidioidomycosis in the Endemic Area of Rio de Janeiro, BrazilEduardo Mastrangelo Marinho Falcão0Dayvison Francis Saraiva Freitas1Ziadir Francisco Coutinho2Leonardo Pereira Quintella3Mauro de Medeiros Muniz4Rodrigo Almeida-Paes5Rosely Maria Zancopé-Oliveira6Priscila Marques de Macedo7Antonio Carlos Francesconi do Valle8Laboratory of Clinical Research on Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, BrazilLaboratory of Clinical Research on Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, BrazilGermano Sinval Faria School Health Center, Sergio Arouca National School of Public Health, Fiocruz, Rio de Janeiro 21040-900, BrazilAnatomical Pathology Service, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, BrazilMycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, BrazilMycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, BrazilMycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, BrazilLaboratory of Clinical Research on Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, BrazilLaboratory of Clinical Research on Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, BrazilParacoccidioidomycosis (PCM) is a neglected endemic mycosis in Latin America. Most cases occur in Brazil. It is classified as PCM infection and PCM disease and is subdivided into chronic (adult type) or acute (juvenile type) disease, with the latter being less frequent and more severe. In 2016, we reported an increase in the numbers of patients diagnosed with acute PCM after a highway’s construction. We conducted a study at INI-Fiocruz, a reference center for infectious diseases, including endemic mycoses, in Rio de Janeiro, Brazil, aiming to deepen the analysis of this new clinical and epidemiological profile of PCM. The authors developed a retrospective study including 170 patients diagnosed with PCM between 2010 and 2019. There was an increase in the number of atypical and severe forms, starting in 2014. In subsequent years, we detected a higher incidence of adverse outcomes with patients requiring more hospitalizations and an increased mortality rate. We estimate that PCM has become more severe throughout the Rio de Janeiro state, affecting a greater number of young individuals and leading to a greater number of and longer hospitalizations. Surveillance measures and close monitoring of future notification data in the state, with emphasis on children, adolescents, and young adults are necessary for a better understanding of the perpetuation of this public health challenge.https://www.mdpi.com/2309-608X/9/9/946paracoccidioidomycosisneglected diseases<i>Paracoccidioides</i>mycoses |
| spellingShingle | Eduardo Mastrangelo Marinho Falcão Dayvison Francis Saraiva Freitas Ziadir Francisco Coutinho Leonardo Pereira Quintella Mauro de Medeiros Muniz Rodrigo Almeida-Paes Rosely Maria Zancopé-Oliveira Priscila Marques de Macedo Antonio Carlos Francesconi do Valle Trends in the Epidemiological and Clinical Profile of Paracoccidioidomycosis in the Endemic Area of Rio de Janeiro, Brazil Journal of Fungi paracoccidioidomycosis neglected diseases <i>Paracoccidioides</i> mycoses |
| title | Trends in the Epidemiological and Clinical Profile of Paracoccidioidomycosis in the Endemic Area of Rio de Janeiro, Brazil |
| title_full | Trends in the Epidemiological and Clinical Profile of Paracoccidioidomycosis in the Endemic Area of Rio de Janeiro, Brazil |
| title_fullStr | Trends in the Epidemiological and Clinical Profile of Paracoccidioidomycosis in the Endemic Area of Rio de Janeiro, Brazil |
| title_full_unstemmed | Trends in the Epidemiological and Clinical Profile of Paracoccidioidomycosis in the Endemic Area of Rio de Janeiro, Brazil |
| title_short | Trends in the Epidemiological and Clinical Profile of Paracoccidioidomycosis in the Endemic Area of Rio de Janeiro, Brazil |
| title_sort | trends in the epidemiological and clinical profile of paracoccidioidomycosis in the endemic area of rio de janeiro brazil |
| topic | paracoccidioidomycosis neglected diseases <i>Paracoccidioides</i> mycoses |
| url | https://www.mdpi.com/2309-608X/9/9/946 |
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