Glucose regulates tissue-specific chondro-osteogenic differentiation of human cartilage endplate stem cells via O-GlcNAcylation of Sox9 and Runx2

Glucose regulates tissue-specific chondro-osteogenic differentiation of human cartilage endplate stem cells via O-GlcNAcylation of Sox9 and Runx2

Abstract Background The degenerative disc disease (DDD) is a major cause of low back pain. The physiological low-glucose microenvironment of the cartilage endplate (CEP) is disrupted in DDD. Glucose influences protein O-GlcNAcylation via the hexosamine biosynthetic pathway (HBP), which is the key to...

Full description

Bibliographic Details
Main Authors: Chao Sun, Weiren Lan, Bin Li, Rui Zuo, Hui Xing, Minghan Liu, Jie Li, Yuan Yao, Junlong Wu, Yu Tang, Huan Liu, Yue Zhou
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Stem Cell Research & Therapy
Subjects:
Glucose
O-GlcNAcylation
Cartilage endplate stem cells
Chondrogenic differentiation
Osteogenic differentiation
Online Access:https://doi.org/10.1186/s13287-019-1440-5

Internet

https://doi.org/10.1186/s13287-019-1440-5

Similar Items