Acute Histopathological Response of Renal Tissues After Varied Fractionated Abdominal 12 Gy Irradiation In Rats
INTRODUCTION[|]The aim of the present study was to evaluate the effect of fraction dose irradiation on kidney damage due to scattered radiation.[¤]METHODS[|] Rats were randomized into 6 groups. Group 1: Control group, a sham irradiation (n=5); Group 2: Hypofractionated total abdominal irradiation (T...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2017-09-01
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| Series: | Southern Clinics of Istanbul Eurasia |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=KEAH-93276 |
| _version_ | 1797918991840182272 |
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| author | Hakan Akdere |
| author_facet | Hakan Akdere |
| author_sort | Hakan Akdere |
| collection | DOAJ |
| description | INTRODUCTION[|]The aim of the present study was to evaluate the effect of fraction dose irradiation on kidney damage due to scattered radiation.[¤]METHODS[|] Rats were randomized into 6 groups. Group 1: Control group, a sham irradiation (n=5); Group 2: Hypofractionated total abdominal irradiation (TAI), total of 12 Gy (2 fractions in 2 days) (n=4); Group 3: Hypofractionated TAI, total of 12 Gy (3 fractions in 3 days; n=6); Group 4: Hypofractionated TAI, total of 12 Gy (4 fractions in 4 days; n=6); Group 5: TAI with conventional fractionation, total of 12 Gy (6 fractions in 6 days; n=6); and Group 6: TAI with conventional fractionation, total of 12 Gy (7 fractions in 7 days; n=6).[¤]RESULTS[|]There was no statistically significant difference (p>0.05) between the hypofractionated group sets of Groups 3-4 (2.66+-0.51) and 5-6 (1.83+-0.40). However, a statistically significant difference was found in the comparison between Group 2 (3.75+-0.51) and the group sets of Groups 3–4 and 5–6 (p<0.05).[¤]DISCUSSION AND CONCLUSION[|]The present study demonstrated that hypofractionated TAI leads to more prominent acute tissue damage in the kidneys than does conventional irradiation.[¤] |
| first_indexed | 2024-04-10T13:38:18Z |
| format | Article |
| id | doaj.art-d1108adc13f046b98b169d4008a44cc7 |
| institution | Directory Open Access Journal |
| issn | 2587-0998 |
| language | English |
| last_indexed | 2024-04-10T13:38:18Z |
| publishDate | 2017-09-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Southern Clinics of Istanbul Eurasia |
| spelling | doaj.art-d1108adc13f046b98b169d4008a44cc72023-02-15T16:11:19ZengKARE PublishingSouthern Clinics of Istanbul Eurasia2587-09982017-09-01282778110.14744/scie.2017.93276KEAH-93276Acute Histopathological Response of Renal Tissues After Varied Fractionated Abdominal 12 Gy Irradiation In RatsHakan Akdere0Department of Urology, Trakya University Faculty of Medicine, Edirne, TurkeyINTRODUCTION[|]The aim of the present study was to evaluate the effect of fraction dose irradiation on kidney damage due to scattered radiation.[¤]METHODS[|] Rats were randomized into 6 groups. Group 1: Control group, a sham irradiation (n=5); Group 2: Hypofractionated total abdominal irradiation (TAI), total of 12 Gy (2 fractions in 2 days) (n=4); Group 3: Hypofractionated TAI, total of 12 Gy (3 fractions in 3 days; n=6); Group 4: Hypofractionated TAI, total of 12 Gy (4 fractions in 4 days; n=6); Group 5: TAI with conventional fractionation, total of 12 Gy (6 fractions in 6 days; n=6); and Group 6: TAI with conventional fractionation, total of 12 Gy (7 fractions in 7 days; n=6).[¤]RESULTS[|]There was no statistically significant difference (p>0.05) between the hypofractionated group sets of Groups 3-4 (2.66+-0.51) and 5-6 (1.83+-0.40). However, a statistically significant difference was found in the comparison between Group 2 (3.75+-0.51) and the group sets of Groups 3–4 and 5–6 (p<0.05).[¤]DISCUSSION AND CONCLUSION[|]The present study demonstrated that hypofractionated TAI leads to more prominent acute tissue damage in the kidneys than does conventional irradiation.[¤]https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=KEAH-93276hypofractionated radiotherapyirradiation damageradiotherapyrenal tissue |
| spellingShingle | Hakan Akdere Acute Histopathological Response of Renal Tissues After Varied Fractionated Abdominal 12 Gy Irradiation In Rats Southern Clinics of Istanbul Eurasia hypofractionated radiotherapy irradiation damage radiotherapy renal tissue |
| title | Acute Histopathological Response of Renal Tissues After Varied Fractionated Abdominal 12 Gy Irradiation In Rats |
| title_full | Acute Histopathological Response of Renal Tissues After Varied Fractionated Abdominal 12 Gy Irradiation In Rats |
| title_fullStr | Acute Histopathological Response of Renal Tissues After Varied Fractionated Abdominal 12 Gy Irradiation In Rats |
| title_full_unstemmed | Acute Histopathological Response of Renal Tissues After Varied Fractionated Abdominal 12 Gy Irradiation In Rats |
| title_short | Acute Histopathological Response of Renal Tissues After Varied Fractionated Abdominal 12 Gy Irradiation In Rats |
| title_sort | acute histopathological response of renal tissues after varied fractionated abdominal 12 gy irradiation in rats |
| topic | hypofractionated radiotherapy irradiation damage radiotherapy renal tissue |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=KEAH-93276 |
| work_keys_str_mv | AT hakanakdere acutehistopathologicalresponseofrenaltissuesaftervariedfractionatedabdominal12gyirradiationinrats |