| Summary: | The skin is the largest organ of the human body, and its main function is protection from external injuries and infectious influences. It is a metabolically active organ that works mainly by self-renewal of the squamous epithelium through continuous differentiation. The surface layer of the skin “epidermis” is updated every four weeks. It is also the body’s largest sensory organ, which can respond to external stimuli such as heat, cold, touch and pressure, which is necessary to maintain the body’s thermostat. Being the largest organ of the body, the skin is an active immune organ and an important peripheral neuro-endocrine organ. It is closely related to the endocrine system and, therefore, contributes to the homeostasis of peripheral hormones. A complex pathophysiology occurs when thyroid hormones are exposed to the skin, especially in the case of a continuing apparent violation of the regulation of thyroid hormones. Thyroid hormone is considered one of the key hormones regulating skin homeostasis. The release of peripheral thyroid hormones (T4 and T3) affects many organs, additionally regulating various functions at the cellular level. In particular, the skin is considered an important target organ, on which the thyroid hormone has a significant effect. Numerous skin diseases are associated with a violation of the regulation of thyroid hormones. Rough skin manifestations are usually the first sign of an imbalance of thyroid hormones, in which they play an integral role in maintaining natural function. This article reviews the pathology of thyroid hormones, as well as skin diseases associated with diseases of the pancreas. The interaction of thyroid gland diseases with the skin, manifested in the form of various skin pathologies, will be considered. It is known that endocrine disorders affect all organ systems of the body, including the skin.
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