Interaction between Fibroblasts and Immune Cells Following DNA Damage Induced by Ionizing Radiation
Cancer-associated fibroblasts (CAF) form the basis of tumor microenvironment and possess immunomodulatory functions by interacting with other cells surrounding tumor, including T lymphocytes, macrophages, dendritic cells and natural killer cells. Ionizing radiation is a broadly-used method in radiot...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/22/8635 |
| _version_ | 1797547789971881984 |
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| author | Kalaiyarasi Ragunathan Nikki Lyn Esnardo Upfold Valentyn Oksenych |
| author_facet | Kalaiyarasi Ragunathan Nikki Lyn Esnardo Upfold Valentyn Oksenych |
| author_sort | Kalaiyarasi Ragunathan |
| collection | DOAJ |
| description | Cancer-associated fibroblasts (CAF) form the basis of tumor microenvironment and possess immunomodulatory functions by interacting with other cells surrounding tumor, including T lymphocytes, macrophages, dendritic cells and natural killer cells. Ionizing radiation is a broadly-used method in radiotherapy to target tumors. In mammalian cells, ionizing radiation induces various types of DNA damages and DNA damage response. Being unspecific, radiotherapy affects all the cells in tumor microenvironment, including the tumor itself, CAFs and immune cells. CAFs are extremely radio-resistant and do not initiate apoptosis even at high doses of radiation. However, following radiation, CAFs become senescent and produce a distinct combination of immunoregulatory molecules. Radiosensitivity of immune cells varies depending on the cell type due to inefficient DNA repair in, for example, monocytes and granulocytes. In this minireview, we are summarizing recent findings on the interaction between CAF, ionizing radiation and immune cells in the tumor microenvironment. |
| first_indexed | 2024-03-10T14:49:13Z |
| format | Article |
| id | doaj.art-d113501394c74cb499b4de3cd72b7b1a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:49:13Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d113501394c74cb499b4de3cd72b7b1a2023-11-20T21:09:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-012122863510.3390/ijms21228635Interaction between Fibroblasts and Immune Cells Following DNA Damage Induced by Ionizing RadiationKalaiyarasi Ragunathan0Nikki Lyn Esnardo Upfold1Valentyn Oksenych2Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7028 Trondheim, NorwayDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7028 Trondheim, NorwayDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7028 Trondheim, NorwayCancer-associated fibroblasts (CAF) form the basis of tumor microenvironment and possess immunomodulatory functions by interacting with other cells surrounding tumor, including T lymphocytes, macrophages, dendritic cells and natural killer cells. Ionizing radiation is a broadly-used method in radiotherapy to target tumors. In mammalian cells, ionizing radiation induces various types of DNA damages and DNA damage response. Being unspecific, radiotherapy affects all the cells in tumor microenvironment, including the tumor itself, CAFs and immune cells. CAFs are extremely radio-resistant and do not initiate apoptosis even at high doses of radiation. However, following radiation, CAFs become senescent and produce a distinct combination of immunoregulatory molecules. Radiosensitivity of immune cells varies depending on the cell type due to inefficient DNA repair in, for example, monocytes and granulocytes. In this minireview, we are summarizing recent findings on the interaction between CAF, ionizing radiation and immune cells in the tumor microenvironment.https://www.mdpi.com/1422-0067/21/22/8635DNA repairlymphocyteimmune systemDNA breakscancer-associated fibroblasts |
| spellingShingle | Kalaiyarasi Ragunathan Nikki Lyn Esnardo Upfold Valentyn Oksenych Interaction between Fibroblasts and Immune Cells Following DNA Damage Induced by Ionizing Radiation International Journal of Molecular Sciences DNA repair lymphocyte immune system DNA breaks cancer-associated fibroblasts |
| title | Interaction between Fibroblasts and Immune Cells Following DNA Damage Induced by Ionizing Radiation |
| title_full | Interaction between Fibroblasts and Immune Cells Following DNA Damage Induced by Ionizing Radiation |
| title_fullStr | Interaction between Fibroblasts and Immune Cells Following DNA Damage Induced by Ionizing Radiation |
| title_full_unstemmed | Interaction between Fibroblasts and Immune Cells Following DNA Damage Induced by Ionizing Radiation |
| title_short | Interaction between Fibroblasts and Immune Cells Following DNA Damage Induced by Ionizing Radiation |
| title_sort | interaction between fibroblasts and immune cells following dna damage induced by ionizing radiation |
| topic | DNA repair lymphocyte immune system DNA breaks cancer-associated fibroblasts |
| url | https://www.mdpi.com/1422-0067/21/22/8635 |
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