Sucralose: From Sweet Success to Metabolic Controversies—Unraveling the Global Health Implications of a Pervasive Non-Caloric Artificial Sweetener
Sucralose is a food additive initially used to mitigate glycemic peaks and calorie intake in patients with diabetes and obesity. Although sucralose has been considered safe for human consumption, the World Health Organization (WHO) issued a global alert in 2023 concerning the potential health implic...
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| Materiálatiipa: | Artihkal |
| Giella: | English |
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MDPI AG
2024-02-01
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| Ráidu: | Life |
| Fáttát: | |
| Liŋkkat: | https://www.mdpi.com/2075-1729/14/3/323 |
| _version_ | 1827305804184682496 |
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| author | José Alfredo Aguayo-Guerrero Lucía Angélica Méndez-García Helena Solleiro-Villavicencio Rebeca Viurcos-Sanabria Galileo Escobedo |
| author_facet | José Alfredo Aguayo-Guerrero Lucía Angélica Méndez-García Helena Solleiro-Villavicencio Rebeca Viurcos-Sanabria Galileo Escobedo |
| author_sort | José Alfredo Aguayo-Guerrero |
| collection | DOAJ |
| description | Sucralose is a food additive initially used to mitigate glycemic peaks and calorie intake in patients with diabetes and obesity. Although sucralose has been considered safe for human consumption, the World Health Organization (WHO) issued a global alert in 2023 concerning the potential health implications of this artificial sweetener. This review aims to comprehensively explore the effects of sucralose intake on human health by understanding sucralose absorption, metabolism, and excretion. We also outline the role of the sweet taste 1 receptor 3 (T1R3) in mediating sucralose-dependent signaling pathways that regulate satiety, incretin release, and insulin response. Finally, we discuss the impact of sucralose on microbiome dysbiosis, inflammatory response origin, liver damage, and toxicity. Gaining a deeper understanding of the manifold effects of sucralose on human physiology will help promote further studies to ensure its consumption is deemed safe for a broader population, including children, adolescents, and pregnant women. |
| first_indexed | 2024-04-24T18:05:16Z |
| format | Article |
| id | doaj.art-d115e48c81cb4cc1b0094d1a0f0b3780 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-04-24T18:05:16Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-d115e48c81cb4cc1b0094d1a0f0b37802024-03-27T13:51:08ZengMDPI AGLife2075-17292024-02-0114332310.3390/life14030323Sucralose: From Sweet Success to Metabolic Controversies—Unraveling the Global Health Implications of a Pervasive Non-Caloric Artificial SweetenerJosé Alfredo Aguayo-Guerrero0Lucía Angélica Méndez-García1Helena Solleiro-Villavicencio2Rebeca Viurcos-Sanabria3Galileo Escobedo4Laboratory of Immunometabolism, Research Division, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoLaboratory of Immunometabolism, Research Division, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoPosgrado en Ciencias Genómicas, Autonomous University of Mexico City, Mexico City 06720, MexicoDepartment of Plastic and Hand Surgery, Medical Center-University of Freiburg, 79106 Freiburg, GermanyLaboratory of Immunometabolism, Research Division, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoSucralose is a food additive initially used to mitigate glycemic peaks and calorie intake in patients with diabetes and obesity. Although sucralose has been considered safe for human consumption, the World Health Organization (WHO) issued a global alert in 2023 concerning the potential health implications of this artificial sweetener. This review aims to comprehensively explore the effects of sucralose intake on human health by understanding sucralose absorption, metabolism, and excretion. We also outline the role of the sweet taste 1 receptor 3 (T1R3) in mediating sucralose-dependent signaling pathways that regulate satiety, incretin release, and insulin response. Finally, we discuss the impact of sucralose on microbiome dysbiosis, inflammatory response origin, liver damage, and toxicity. Gaining a deeper understanding of the manifold effects of sucralose on human physiology will help promote further studies to ensure its consumption is deemed safe for a broader population, including children, adolescents, and pregnant women.https://www.mdpi.com/2075-1729/14/3/323sucralosenon-caloric artificial sweetenersT1R3microbiotaliver damageinsulin resistance |
| spellingShingle | José Alfredo Aguayo-Guerrero Lucía Angélica Méndez-García Helena Solleiro-Villavicencio Rebeca Viurcos-Sanabria Galileo Escobedo Sucralose: From Sweet Success to Metabolic Controversies—Unraveling the Global Health Implications of a Pervasive Non-Caloric Artificial Sweetener Life sucralose non-caloric artificial sweeteners T1R3 microbiota liver damage insulin resistance |
| title | Sucralose: From Sweet Success to Metabolic Controversies—Unraveling the Global Health Implications of a Pervasive Non-Caloric Artificial Sweetener |
| title_full | Sucralose: From Sweet Success to Metabolic Controversies—Unraveling the Global Health Implications of a Pervasive Non-Caloric Artificial Sweetener |
| title_fullStr | Sucralose: From Sweet Success to Metabolic Controversies—Unraveling the Global Health Implications of a Pervasive Non-Caloric Artificial Sweetener |
| title_full_unstemmed | Sucralose: From Sweet Success to Metabolic Controversies—Unraveling the Global Health Implications of a Pervasive Non-Caloric Artificial Sweetener |
| title_short | Sucralose: From Sweet Success to Metabolic Controversies—Unraveling the Global Health Implications of a Pervasive Non-Caloric Artificial Sweetener |
| title_sort | sucralose from sweet success to metabolic controversies unraveling the global health implications of a pervasive non caloric artificial sweetener |
| topic | sucralose non-caloric artificial sweeteners T1R3 microbiota liver damage insulin resistance |
| url | https://www.mdpi.com/2075-1729/14/3/323 |
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