HIV-1 provirus transcription and translation in macrophages differs from pre-integrated cDNA complexes and requires E2F transcriptional programs

HIV-1 provirus transcription and translation in macrophages differs from pre-integrated cDNA complexes and requires E2F transcriptional programs

HIV-1 cDNA pre-integration complexes persist for weeks in macrophages and remain transcriptionally active. While previous work has focused on the transcription of HIV-1 genes; our understanding of the cellular milieu that accompanies viral production is incomplete. We have used an in vitro system to...

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Bibliographic Details
Main Authors: Albebson L. Lim, Philip Moos, Christopher D. Pond, Erica C. Larson, Laura J. Martins, Matthew A. Szaniawski, Vicente Planelles, Louis R. Barrows
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Virulence
Subjects:
hiv-1
macrophages
single cell rna sequencing
infection
pre-integrated cdna complex transcription
provirus transcription
Online Access:http://dx.doi.org/10.1080/21505594.2022.2031583

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