Intravenous methylprednisolone in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP)
HTLV-I (Human T-lymphotropic virus type I) associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an immunomediated myelopathy induced by the HTLV-I. Some patients, specially those from Japan, seem to have a good response to steroid treatment. However, this has not been found in other regio...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
1993-09-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1993000300005&lng=en&tlng=en |
| _version_ | 1819113026733735936 |
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| author | Abelardo Q-C Araújo Cristiane R. Afonso Ana Claudia B. Leite Solange V. Dultra |
| author_facet | Abelardo Q-C Araújo Cristiane R. Afonso Ana Claudia B. Leite Solange V. Dultra |
| author_sort | Abelardo Q-C Araújo |
| collection | DOAJ |
| description | HTLV-I (Human T-lymphotropic virus type I) associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an immunomediated myelopathy induced by the HTLV-I. Some patients, specially those from Japan, seem to have a good response to steroid treatment. However, this has not been found in other regions of the world. High dose intravenous methylprednisolone has been used with success in patients with relapses of multiple sclerosis (MS), another autoimmune disease of the central nervous system. To test the effectiveness of methylprednisolone in patients with HAM/TSP, we devised an open trial in 23 patients. We found a very limited benefit of this form of treatment in these patients. Only one patient, who had the shortest disease duration (five months) in the whole group, showed a sustained benefit. We speculate that those patients with a shorter history, with presumably less demye-lination and more inflammatory lesions, would show a better response to immunossupressive treatments. |
| first_indexed | 2024-12-22T04:22:52Z |
| format | Article |
| id | doaj.art-d1181a2071f543098e92d62a1262be78 |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-12-22T04:22:52Z |
| publishDate | 1993-09-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-d1181a2071f543098e92d62a1262be782022-12-21T18:39:14ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42271993-09-01513325328S0004-282X1993000300005Intravenous methylprednisolone in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP)Abelardo Q-C Araújo0Cristiane R. Afonso1Ana Claudia B. Leite2Solange V. Dultra3Fundação Oswaldo CruzUniversidade Federal do Rio de JaneiroFundação Oswaldo CruzFundação Oswaldo CruzHTLV-I (Human T-lymphotropic virus type I) associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an immunomediated myelopathy induced by the HTLV-I. Some patients, specially those from Japan, seem to have a good response to steroid treatment. However, this has not been found in other regions of the world. High dose intravenous methylprednisolone has been used with success in patients with relapses of multiple sclerosis (MS), another autoimmune disease of the central nervous system. To test the effectiveness of methylprednisolone in patients with HAM/TSP, we devised an open trial in 23 patients. We found a very limited benefit of this form of treatment in these patients. Only one patient, who had the shortest disease duration (five months) in the whole group, showed a sustained benefit. We speculate that those patients with a shorter history, with presumably less demye-lination and more inflammatory lesions, would show a better response to immunossupressive treatments.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1993000300005&lng=en&tlng=enHTLV-Iparaparesia espástica tropicalmetilprednisolona |
| spellingShingle | Abelardo Q-C Araújo Cristiane R. Afonso Ana Claudia B. Leite Solange V. Dultra Intravenous methylprednisolone in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) Arquivos de Neuro-Psiquiatria HTLV-I paraparesia espástica tropical metilprednisolona |
| title | Intravenous methylprednisolone in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) |
| title_full | Intravenous methylprednisolone in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) |
| title_fullStr | Intravenous methylprednisolone in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) |
| title_full_unstemmed | Intravenous methylprednisolone in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) |
| title_short | Intravenous methylprednisolone in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) |
| title_sort | intravenous methylprednisolone in htlv i associated myelopathy tropical spastic paraparesis ham tsp |
| topic | HTLV-I paraparesia espástica tropical metilprednisolona |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1993000300005&lng=en&tlng=en |
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