Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and Dexamethasone Analgesia in an Animal Model of Low Back Pain

Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and Dexamethasone Analgesia in an Animal Model of Low Back Pain

Low back pain, a leading cause of disability, is commonly treated by epidural steroid injections that target the anti-inflammatory glucocorticoid receptor (GR). However, their efficacy has been controversial. All currently used epidural steroids also activate the pro-inflammatory mineralocorticoid r...

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Bibliographic Details
Main Authors: Shaimaa I. A. Ibrahim, Wenrui Xie, Judith A. Strong, Raquel Tonello, Temugin Berta, Jun-Ming Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
back pain
epidural steroids
inflammation
glucocorticoids
dorsal root ganglion
mineralocorticoid receptor
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00453/full

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