A self-elastic chitosan sponge integrating active and passive hemostatic mechanisms for effectively managing uncontrolled coagulopathic hemorrhage
Developing a self-elastic sponge integrating active and passive hemostatic mechanisms for the effective management of uncontrolled coagulopathic hemorrhage remains a challenge. We here developed a chitosan-based sponge by integrating freeze-drying, chemical decoration of alkyl chains and phosphate g...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424000905 |
| _version_ | 1797242981793660928 |
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| author | Xinchen Du Tongxing Zhang Yadong Liu Tong Li Jiuxia Yang Xuelei Li Lianyong Wang |
| author_facet | Xinchen Du Tongxing Zhang Yadong Liu Tong Li Jiuxia Yang Xuelei Li Lianyong Wang |
| author_sort | Xinchen Du |
| collection | DOAJ |
| description | Developing a self-elastic sponge integrating active and passive hemostatic mechanisms for the effective management of uncontrolled coagulopathic hemorrhage remains a challenge. We here developed a chitosan-based sponge by integrating freeze-drying, chemical decoration of alkyl chains and phosphate groups, and physical loading of thrombin. The sponge exhibited high mechanical strength, self-elasticity, and rapid shape recovery. The sponge facilitated blood cell adhesion, aggregation, and activation through hydrophobic and electrostatic interactions, as well as accelerated blood clotting. The sponge exhibited higher efficacy than commercial gauze and gelatin sponge in managing uncontrolled hemorrhage from heparinized rat tail amputation, liver superficial injury, and liver perforating wound models. In addition, the sponge exhibited favorable biodegradability and biocompatibility. These findings revealed that the developed sponge holds great potential as a novel hemostat for effectively managing uncontrolled coagulopathic hemorrhage from superficial and perforating wounds. |
| first_indexed | 2024-04-24T18:47:52Z |
| format | Article |
| id | doaj.art-d11954e820424ae3aed2ddea701d601a |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-04-24T18:47:52Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-d11954e820424ae3aed2ddea701d601a2024-03-27T04:52:44ZengElsevierMaterials Today Bio2590-00642024-06-0126101031A self-elastic chitosan sponge integrating active and passive hemostatic mechanisms for effectively managing uncontrolled coagulopathic hemorrhageXinchen Du0Tongxing Zhang1Yadong Liu2Tong Li3Jiuxia Yang4Xuelei Li5Lianyong Wang6Department of Chemical and Environmental Engineering, Hetao College, Bayannaoer, Inner Mongoli, 015000, China; Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, 300071, ChinaDepartment of Minimally Invasive Spine Surgery, Tianjin Hospital, Tianjin University, No. 406, Jiefangnan Road, Hexi District, Tianjin, 300211, ChinaDepartment of Chemical and Environmental Engineering, Hetao College, Bayannaoer, Inner Mongoli, 015000, ChinaDepartment of Minimally Invasive Spine Surgery, Tianjin Hospital, Tianjin University, No. 406, Jiefangnan Road, Hexi District, Tianjin, 300211, ChinaKey Laboratory of Critical Care Medicine, Tianjin First Central Hospital, Tianjin, 300071, ChinaDepartment of Chemical and Environmental Engineering, Hetao College, Bayannaoer, Inner Mongoli, 015000, China; Corresponding author.Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, 300071, China; Corresponding author.Developing a self-elastic sponge integrating active and passive hemostatic mechanisms for the effective management of uncontrolled coagulopathic hemorrhage remains a challenge. We here developed a chitosan-based sponge by integrating freeze-drying, chemical decoration of alkyl chains and phosphate groups, and physical loading of thrombin. The sponge exhibited high mechanical strength, self-elasticity, and rapid shape recovery. The sponge facilitated blood cell adhesion, aggregation, and activation through hydrophobic and electrostatic interactions, as well as accelerated blood clotting. The sponge exhibited higher efficacy than commercial gauze and gelatin sponge in managing uncontrolled hemorrhage from heparinized rat tail amputation, liver superficial injury, and liver perforating wound models. In addition, the sponge exhibited favorable biodegradability and biocompatibility. These findings revealed that the developed sponge holds great potential as a novel hemostat for effectively managing uncontrolled coagulopathic hemorrhage from superficial and perforating wounds.http://www.sciencedirect.com/science/article/pii/S2590006424000905ThrombinSelf-elastic chitosan spongeRapid shape recoveryUncontrolled coagulopathic hemorrhageHemostasis |
| spellingShingle | Xinchen Du Tongxing Zhang Yadong Liu Tong Li Jiuxia Yang Xuelei Li Lianyong Wang A self-elastic chitosan sponge integrating active and passive hemostatic mechanisms for effectively managing uncontrolled coagulopathic hemorrhage Materials Today Bio Thrombin Self-elastic chitosan sponge Rapid shape recovery Uncontrolled coagulopathic hemorrhage Hemostasis |
| title | A self-elastic chitosan sponge integrating active and passive hemostatic mechanisms for effectively managing uncontrolled coagulopathic hemorrhage |
| title_full | A self-elastic chitosan sponge integrating active and passive hemostatic mechanisms for effectively managing uncontrolled coagulopathic hemorrhage |
| title_fullStr | A self-elastic chitosan sponge integrating active and passive hemostatic mechanisms for effectively managing uncontrolled coagulopathic hemorrhage |
| title_full_unstemmed | A self-elastic chitosan sponge integrating active and passive hemostatic mechanisms for effectively managing uncontrolled coagulopathic hemorrhage |
| title_short | A self-elastic chitosan sponge integrating active and passive hemostatic mechanisms for effectively managing uncontrolled coagulopathic hemorrhage |
| title_sort | self elastic chitosan sponge integrating active and passive hemostatic mechanisms for effectively managing uncontrolled coagulopathic hemorrhage |
| topic | Thrombin Self-elastic chitosan sponge Rapid shape recovery Uncontrolled coagulopathic hemorrhage Hemostasis |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424000905 |
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