Creation of Artificial Cell-Like Structures Promoted by Microfluidics Technologies
The creation of artificial cells is an immensely challenging task in science. Artificial cells contribute to revealing the mechanisms of biological systems and deepening our understanding of them. The progress of versatile biological research fields has clarified many biological phenomena, and vario...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-03-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/10/4/216 |
| _version_ | 1818175238170476544 |
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| author | Yusuke Sato Masahiro Takinoue |
| author_facet | Yusuke Sato Masahiro Takinoue |
| author_sort | Yusuke Sato |
| collection | DOAJ |
| description | The creation of artificial cells is an immensely challenging task in science. Artificial cells contribute to revealing the mechanisms of biological systems and deepening our understanding of them. The progress of versatile biological research fields has clarified many biological phenomena, and various artificial cell models have been proposed in these fields. Microfluidics provides useful technologies for the study of artificial cells because it allows the fabrication of cell-like compartments, including water-in-oil emulsions and giant unilamellar vesicles. Furthermore, microfluidics also allows the mimicry of cellular functions with chip devices based on sophisticated chamber design. In this review, we describe contributions of microfluidics to the study of artificial cells. Although typical microfluidic methods are useful for the creation of artificial-cell compartments, recent methods provide further benefits, including low-cost fabrication and a reduction of the sample volume. Microfluidics also allows us to create multi-compartments, compartments with artificial organelles, and on-chip artificial cells. We discuss these topics and the future perspective of microfluidics for the study of artificial cells and molecular robotics. |
| first_indexed | 2024-12-11T19:57:07Z |
| format | Article |
| id | doaj.art-d11c3e5abc064309b7c73f9e8e674dec |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-12-11T19:57:07Z |
| publishDate | 2019-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-d11c3e5abc064309b7c73f9e8e674dec2022-12-22T00:52:36ZengMDPI AGMicromachines2072-666X2019-03-0110421610.3390/mi10040216mi10040216Creation of Artificial Cell-Like Structures Promoted by Microfluidics TechnologiesYusuke Sato0Masahiro Takinoue1Department of Computer Science, Tokyo Institute of Technology, Kanagawa 226-8502, JapanDepartment of Computer Science, Tokyo Institute of Technology, Kanagawa 226-8502, JapanThe creation of artificial cells is an immensely challenging task in science. Artificial cells contribute to revealing the mechanisms of biological systems and deepening our understanding of them. The progress of versatile biological research fields has clarified many biological phenomena, and various artificial cell models have been proposed in these fields. Microfluidics provides useful technologies for the study of artificial cells because it allows the fabrication of cell-like compartments, including water-in-oil emulsions and giant unilamellar vesicles. Furthermore, microfluidics also allows the mimicry of cellular functions with chip devices based on sophisticated chamber design. In this review, we describe contributions of microfluidics to the study of artificial cells. Although typical microfluidic methods are useful for the creation of artificial-cell compartments, recent methods provide further benefits, including low-cost fabrication and a reduction of the sample volume. Microfluidics also allows us to create multi-compartments, compartments with artificial organelles, and on-chip artificial cells. We discuss these topics and the future perspective of microfluidics for the study of artificial cells and molecular robotics.https://www.mdpi.com/2072-666X/10/4/216microfluidicswater-in-oil emulsionliposomelipid vesiclechemical communicationartificial cellson-chip artificial cellsartificial molecular systemsmolecular robotics |
| spellingShingle | Yusuke Sato Masahiro Takinoue Creation of Artificial Cell-Like Structures Promoted by Microfluidics Technologies Micromachines microfluidics water-in-oil emulsion liposome lipid vesicle chemical communication artificial cells on-chip artificial cells artificial molecular systems molecular robotics |
| title | Creation of Artificial Cell-Like Structures Promoted by Microfluidics Technologies |
| title_full | Creation of Artificial Cell-Like Structures Promoted by Microfluidics Technologies |
| title_fullStr | Creation of Artificial Cell-Like Structures Promoted by Microfluidics Technologies |
| title_full_unstemmed | Creation of Artificial Cell-Like Structures Promoted by Microfluidics Technologies |
| title_short | Creation of Artificial Cell-Like Structures Promoted by Microfluidics Technologies |
| title_sort | creation of artificial cell like structures promoted by microfluidics technologies |
| topic | microfluidics water-in-oil emulsion liposome lipid vesicle chemical communication artificial cells on-chip artificial cells artificial molecular systems molecular robotics |
| url | https://www.mdpi.com/2072-666X/10/4/216 |
| work_keys_str_mv | AT yusukesato creationofartificialcelllikestructurespromotedbymicrofluidicstechnologies AT masahirotakinoue creationofartificialcelllikestructurespromotedbymicrofluidicstechnologies |