Antihyperglycemic activity of Caralluma quadrangula in streptozotocin-induced diabetic rats
Diabetes of type 2 is a worldwide epidemic disease of global prevalence. Caralluma quadrangula is wild Saudi plant used by traditional healers as antidiabetic, in case of hunger, and many other diseases. Nothing was reported to justify the use of the plant in case of diabetes. The plant material was...
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| Format: | Article |
| Language: | English |
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Faculty of Pharmacy, Cairo University
2017-12-01
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| Series: | Bulletin of Faculty of Pharmacy Cairo University |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110093117300352 |
| _version_ | 1828073276111323136 |
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| author | Essam Abdel-Sattar Shohda A. EL-Maraghy Riham Salah El-Dine Sherine M. Rizk |
| author_facet | Essam Abdel-Sattar Shohda A. EL-Maraghy Riham Salah El-Dine Sherine M. Rizk |
| author_sort | Essam Abdel-Sattar |
| collection | DOAJ |
| description | Diabetes of type 2 is a worldwide epidemic disease of global prevalence. Caralluma quadrangula is wild Saudi plant used by traditional healers as antidiabetic, in case of hunger, and many other diseases. Nothing was reported to justify the use of the plant in case of diabetes. The plant material was extracted with water and with methanol, the methanol fraction was further fractionated into chloroform, n-butanol, in addition to the remaining mother liquor. The water and methanolic extracts as well as different methanolic fractions were evaluated in STZ-induced diabetic rats for their antihyperglycaemic activity. The results showed a significant decrease in fasting blood glucose levels in diabetic treated rats after the administration of most of the extracts and fractions of C. quadrangula and glibenclamide. The most potent activity was shown by administration of the methanolic extract (200 mg/kg), chloroform, n-butanol fraction at dose of 100 mg/kg, as well as the major pregnane glycoside russelioside B isolated from C. quadrangula. In conclusion, this study proved the traditional use of C. quadrangula in diabetes mellitus. Keywords: Asclepiadaceae, Caralluma quadrangula, Antihyperglycemic, Fast blood glucose, G-6-Pase, Insulin |
| first_indexed | 2024-04-11T01:24:14Z |
| format | Article |
| id | doaj.art-d1210ed02ca248b48729a1a70d97bc96 |
| institution | Directory Open Access Journal |
| issn | 1110-0931 |
| language | English |
| last_indexed | 2024-04-11T01:24:14Z |
| publishDate | 2017-12-01 |
| publisher | Faculty of Pharmacy, Cairo University |
| record_format | Article |
| series | Bulletin of Faculty of Pharmacy Cairo University |
| spelling | doaj.art-d1210ed02ca248b48729a1a70d97bc962023-01-03T10:43:28ZengFaculty of Pharmacy, Cairo UniversityBulletin of Faculty of Pharmacy Cairo University1110-09312017-12-01552269272Antihyperglycemic activity of Caralluma quadrangula in streptozotocin-induced diabetic ratsEssam Abdel-Sattar0Shohda A. EL-Maraghy1Riham Salah El-Dine2Sherine M. Rizk3Pharmacognosy Department, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt; Corresponding author.Biochemistry Department, Faculty of Pharmacy, Cairo University, 11562 Cairo, EgyptPharmacognosy Department, Faculty of Pharmacy, Cairo University, 11562 Cairo, EgyptBiochemistry Department, Faculty of Pharmacy, Cairo University, 11562 Cairo, EgyptDiabetes of type 2 is a worldwide epidemic disease of global prevalence. Caralluma quadrangula is wild Saudi plant used by traditional healers as antidiabetic, in case of hunger, and many other diseases. Nothing was reported to justify the use of the plant in case of diabetes. The plant material was extracted with water and with methanol, the methanol fraction was further fractionated into chloroform, n-butanol, in addition to the remaining mother liquor. The water and methanolic extracts as well as different methanolic fractions were evaluated in STZ-induced diabetic rats for their antihyperglycaemic activity. The results showed a significant decrease in fasting blood glucose levels in diabetic treated rats after the administration of most of the extracts and fractions of C. quadrangula and glibenclamide. The most potent activity was shown by administration of the methanolic extract (200 mg/kg), chloroform, n-butanol fraction at dose of 100 mg/kg, as well as the major pregnane glycoside russelioside B isolated from C. quadrangula. In conclusion, this study proved the traditional use of C. quadrangula in diabetes mellitus. Keywords: Asclepiadaceae, Caralluma quadrangula, Antihyperglycemic, Fast blood glucose, G-6-Pase, Insulinhttp://www.sciencedirect.com/science/article/pii/S1110093117300352 |
| spellingShingle | Essam Abdel-Sattar Shohda A. EL-Maraghy Riham Salah El-Dine Sherine M. Rizk Antihyperglycemic activity of Caralluma quadrangula in streptozotocin-induced diabetic rats Bulletin of Faculty of Pharmacy Cairo University |
| title | Antihyperglycemic activity of Caralluma quadrangula in streptozotocin-induced diabetic rats |
| title_full | Antihyperglycemic activity of Caralluma quadrangula in streptozotocin-induced diabetic rats |
| title_fullStr | Antihyperglycemic activity of Caralluma quadrangula in streptozotocin-induced diabetic rats |
| title_full_unstemmed | Antihyperglycemic activity of Caralluma quadrangula in streptozotocin-induced diabetic rats |
| title_short | Antihyperglycemic activity of Caralluma quadrangula in streptozotocin-induced diabetic rats |
| title_sort | antihyperglycemic activity of caralluma quadrangula in streptozotocin induced diabetic rats |
| url | http://www.sciencedirect.com/science/article/pii/S1110093117300352 |
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