Stochastic model of integrin-mediated signaling and adhesion dynamics at the leading edges of migrating cells.

Stochastic model of integrin-mediated signaling and adhesion dynamics at the leading edges of migrating cells.

Productive cell migration requires the spatiotemporal coordination of cell adhesion, membrane protrusion, and actomyosin-mediated contraction. Integrins, engaged by the extracellular matrix (ECM), nucleate the formation of adhesive contacts at the cell's leading edge(s), and maturation of nasce...

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Bibliographic Details
Main Authors: Murat Cirit, Matej Krajcovic, Colin K Choi, Erik S Welf, Alan F Horwitz, Jason M Haugh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2829041?pdf=render

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