Synthesis of New Styrylquinoline Cellular Dyes, Fluorescent Properties, Cellular Localization and Cytotoxic Behavior.
New styrylquinoline derivatives with their photophysical constants are described. The synthesis was achieved via Sonogashira coupling using the newly developed heterogeneous nano-Pd/Cu catalyst system, which provides an efficient synthesis of high purity products. The compounds were tested in prelim...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4482625?pdf=render |
| _version_ | 1818337451269160960 |
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| author | Marzena Rams-Baron Mateusz Dulski Anna Mrozek-Wilczkiewicz Mateusz Korzec Wioleta Cieslik Ewelina Spaczyńska Piotr Bartczak Alicja Ratuszna Jaroslaw Polanski Robert Musiol |
| author_facet | Marzena Rams-Baron Mateusz Dulski Anna Mrozek-Wilczkiewicz Mateusz Korzec Wioleta Cieslik Ewelina Spaczyńska Piotr Bartczak Alicja Ratuszna Jaroslaw Polanski Robert Musiol |
| author_sort | Marzena Rams-Baron |
| collection | DOAJ |
| description | New styrylquinoline derivatives with their photophysical constants are described. The synthesis was achieved via Sonogashira coupling using the newly developed heterogeneous nano-Pd/Cu catalyst system, which provides an efficient synthesis of high purity products. The compounds were tested in preliminary fluorescent microscopy studies to in order to identify their preferable cellular localization, which appeared to be in the lipid cellular organelles. The spectroscopic properties of the compounds were measured and theoretical TD-DFT calculations were performed. A biological analysis of the quinolines that were tested consisted of cytotoxicity assays against normal human fibroblasts and colon adenocarcinoma cells. All of the compounds that were studied appeared to be safe and indifferent to cells in a high concentration range. The presented results suggest that the quinoline compounds that were investigated in this study may be valuable structures for development as fluorescent dyes that could have biological applications. |
| first_indexed | 2024-12-13T14:55:25Z |
| format | Article |
| id | doaj.art-d123d87bdc05428288aa3b2c71725a1a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T14:55:25Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d123d87bdc05428288aa3b2c71725a1a2022-12-21T23:41:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e013121010.1371/journal.pone.0131210Synthesis of New Styrylquinoline Cellular Dyes, Fluorescent Properties, Cellular Localization and Cytotoxic Behavior.Marzena Rams-BaronMateusz DulskiAnna Mrozek-WilczkiewiczMateusz KorzecWioleta CieslikEwelina SpaczyńskaPiotr BartczakAlicja RatusznaJaroslaw PolanskiRobert MusiolNew styrylquinoline derivatives with their photophysical constants are described. The synthesis was achieved via Sonogashira coupling using the newly developed heterogeneous nano-Pd/Cu catalyst system, which provides an efficient synthesis of high purity products. The compounds were tested in preliminary fluorescent microscopy studies to in order to identify their preferable cellular localization, which appeared to be in the lipid cellular organelles. The spectroscopic properties of the compounds were measured and theoretical TD-DFT calculations were performed. A biological analysis of the quinolines that were tested consisted of cytotoxicity assays against normal human fibroblasts and colon adenocarcinoma cells. All of the compounds that were studied appeared to be safe and indifferent to cells in a high concentration range. The presented results suggest that the quinoline compounds that were investigated in this study may be valuable structures for development as fluorescent dyes that could have biological applications.http://europepmc.org/articles/PMC4482625?pdf=render |
| spellingShingle | Marzena Rams-Baron Mateusz Dulski Anna Mrozek-Wilczkiewicz Mateusz Korzec Wioleta Cieslik Ewelina Spaczyńska Piotr Bartczak Alicja Ratuszna Jaroslaw Polanski Robert Musiol Synthesis of New Styrylquinoline Cellular Dyes, Fluorescent Properties, Cellular Localization and Cytotoxic Behavior. PLoS ONE |
| title | Synthesis of New Styrylquinoline Cellular Dyes, Fluorescent Properties, Cellular Localization and Cytotoxic Behavior. |
| title_full | Synthesis of New Styrylquinoline Cellular Dyes, Fluorescent Properties, Cellular Localization and Cytotoxic Behavior. |
| title_fullStr | Synthesis of New Styrylquinoline Cellular Dyes, Fluorescent Properties, Cellular Localization and Cytotoxic Behavior. |
| title_full_unstemmed | Synthesis of New Styrylquinoline Cellular Dyes, Fluorescent Properties, Cellular Localization and Cytotoxic Behavior. |
| title_short | Synthesis of New Styrylquinoline Cellular Dyes, Fluorescent Properties, Cellular Localization and Cytotoxic Behavior. |
| title_sort | synthesis of new styrylquinoline cellular dyes fluorescent properties cellular localization and cytotoxic behavior |
| url | http://europepmc.org/articles/PMC4482625?pdf=render |
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