A Biodegradable Bioactive Glass-Based Hydration Sensor for Biomedical Applications
Monitoring changes in edema-associated intracranial pressure that complicates trauma or surgery would lead to improved outcomes. Implantable pressure sensors have been explored, but these sensors require post-surgical removal, leading to the risk of injury to brain tissue. The use of biodegradable i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/14/1/226 |
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| author | Amina Gharbi Ahmed Yahia Kallel Olfa Kanoun Wissem Cheikhrouhou-Koubaa Christopher H. Contag Iulian Antoniac Nabil Derbel Nureddin Ashammakhi |
| author_facet | Amina Gharbi Ahmed Yahia Kallel Olfa Kanoun Wissem Cheikhrouhou-Koubaa Christopher H. Contag Iulian Antoniac Nabil Derbel Nureddin Ashammakhi |
| author_sort | Amina Gharbi |
| collection | DOAJ |
| description | Monitoring changes in edema-associated intracranial pressure that complicates trauma or surgery would lead to improved outcomes. Implantable pressure sensors have been explored, but these sensors require post-surgical removal, leading to the risk of injury to brain tissue. The use of biodegradable implantable sensors would help to eliminate this risk. Here, we demonstrate a bioactive glass (BaG)-based hydration sensor. Fluorine (CaF<sub>2</sub>) containing BaG (BaG-F) was produced by adding 5, 10 or 20 wt.% of CaF<sub>2</sub> to a BaG matrix using a melting manufacturing technique. The structure, morphology and electrical properties of the resulting constructs were evaluated to understand the physical and electrical behaviors of this BaG-based sensor. Synthesis process for the production of the BaG-F-based sensor was validated by assessing the structural and electrical properties. The structure was observed to be amorphous and dense, the porosity decreased and grain size increased with increasing CaF<sub>2</sub> content in the BaG matrix. We demonstrated that this BaG-F chemical composition is highly sensitive to hydration, and that the electrical sensitivity (resistive–capacitive) is induced by hydration and reversed by dehydration. These properties make BaG-F suitable for use as a humidity sensor to monitor brain edema and, consequently, provide an alert for increased intracranial pressure. |
| first_indexed | 2024-03-09T11:39:37Z |
| format | Article |
| id | doaj.art-d12446cc38954c2eacfd7c807b418d9c |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-09T11:39:37Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-d12446cc38954c2eacfd7c807b418d9c2023-11-30T23:34:56ZengMDPI AGMicromachines2072-666X2023-01-0114122610.3390/mi14010226A Biodegradable Bioactive Glass-Based Hydration Sensor for Biomedical ApplicationsAmina Gharbi0Ahmed Yahia Kallel1Olfa Kanoun2Wissem Cheikhrouhou-Koubaa3Christopher H. Contag4Iulian Antoniac5Nabil Derbel6Nureddin Ashammakhi7CEM Lab, National Engineering School of Sfax, Sfax University, Sfax 3018, TunisiaMST, Chair for Measurement and Sensor Technology, Technische Universittät Chemnitz, 09111 Chemnitz, GermanyMST, Chair for Measurement and Sensor Technology, Technische Universittät Chemnitz, 09111 Chemnitz, GermanyTechnopole de Sfax. BP 275, LT2S Lab, Centre de Recherche en Numérique de Sfax, Sfax 3000, TunisiaInstitute for Quantitative Health Science and Engineering (IQ) and Department of Biomedical Engineering (BME), Michigan State University, East Lansing, MI 48824, USASIM, Faculty of Material Science and Engineering, University Politehnica of Bucharest, 313 Bucharest, RomaniaCEM Lab, National Engineering School of Sfax, Sfax University, Sfax 3018, TunisiaInstitute for Quantitative Health Science and Engineering (IQ) and Department of Biomedical Engineering (BME), Michigan State University, East Lansing, MI 48824, USAMonitoring changes in edema-associated intracranial pressure that complicates trauma or surgery would lead to improved outcomes. Implantable pressure sensors have been explored, but these sensors require post-surgical removal, leading to the risk of injury to brain tissue. The use of biodegradable implantable sensors would help to eliminate this risk. Here, we demonstrate a bioactive glass (BaG)-based hydration sensor. Fluorine (CaF<sub>2</sub>) containing BaG (BaG-F) was produced by adding 5, 10 or 20 wt.% of CaF<sub>2</sub> to a BaG matrix using a melting manufacturing technique. The structure, morphology and electrical properties of the resulting constructs were evaluated to understand the physical and electrical behaviors of this BaG-based sensor. Synthesis process for the production of the BaG-F-based sensor was validated by assessing the structural and electrical properties. The structure was observed to be amorphous and dense, the porosity decreased and grain size increased with increasing CaF<sub>2</sub> content in the BaG matrix. We demonstrated that this BaG-F chemical composition is highly sensitive to hydration, and that the electrical sensitivity (resistive–capacitive) is induced by hydration and reversed by dehydration. These properties make BaG-F suitable for use as a humidity sensor to monitor brain edema and, consequently, provide an alert for increased intracranial pressure.https://www.mdpi.com/2072-666X/14/1/226bioactive glassbiodegradablebrain edemacapacitive sensorhydration monitoring |
| spellingShingle | Amina Gharbi Ahmed Yahia Kallel Olfa Kanoun Wissem Cheikhrouhou-Koubaa Christopher H. Contag Iulian Antoniac Nabil Derbel Nureddin Ashammakhi A Biodegradable Bioactive Glass-Based Hydration Sensor for Biomedical Applications Micromachines bioactive glass biodegradable brain edema capacitive sensor hydration monitoring |
| title | A Biodegradable Bioactive Glass-Based Hydration Sensor for Biomedical Applications |
| title_full | A Biodegradable Bioactive Glass-Based Hydration Sensor for Biomedical Applications |
| title_fullStr | A Biodegradable Bioactive Glass-Based Hydration Sensor for Biomedical Applications |
| title_full_unstemmed | A Biodegradable Bioactive Glass-Based Hydration Sensor for Biomedical Applications |
| title_short | A Biodegradable Bioactive Glass-Based Hydration Sensor for Biomedical Applications |
| title_sort | biodegradable bioactive glass based hydration sensor for biomedical applications |
| topic | bioactive glass biodegradable brain edema capacitive sensor hydration monitoring |
| url | https://www.mdpi.com/2072-666X/14/1/226 |
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