The potential of biology-guided radiation therapy in thoracic cancer: A preliminary treatment planning study
PurposeWe investigated the feasibility of biology-guided radiotherapy (BgRT), a technique that utilizes real-time positron emission imaging to minimize tumor motion uncertainties, to spare nearby organs at risk.MethodsVolumetric modulated arc therapy (VMAT), intensity-modulated proton (IMPT) therapy...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.921473/full |
| _version_ | 1828103761915019264 |
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| author | Steven N. Seyedin Rostem Bassalow Osama R. Mawlawi Lehendrick M. Turner Roshal R. Patel Samuel R. Mazin Oluwaseyi M. Oderinde Yevgen Voronenko Cody A. Wages Peter D. Olcott Joe Y. Chang Peter A. Balter James W. Welsh |
| author_facet | Steven N. Seyedin Rostem Bassalow Osama R. Mawlawi Lehendrick M. Turner Roshal R. Patel Samuel R. Mazin Oluwaseyi M. Oderinde Yevgen Voronenko Cody A. Wages Peter D. Olcott Joe Y. Chang Peter A. Balter James W. Welsh |
| author_sort | Steven N. Seyedin |
| collection | DOAJ |
| description | PurposeWe investigated the feasibility of biology-guided radiotherapy (BgRT), a technique that utilizes real-time positron emission imaging to minimize tumor motion uncertainties, to spare nearby organs at risk.MethodsVolumetric modulated arc therapy (VMAT), intensity-modulated proton (IMPT) therapy, and BgRT plans were created for a paratracheal node recurrence (case 1; 60 Gy in 10 fractions) and a primary peripheral left upper lobe adenocarcinoma (case 2; 50 Gy in four fractions).ResultsFor case 1, BgRT produced lower bronchus V40 values compared to VMAT and IMPT. For case 2, total lung V20 was lower in the BgRT case compared to VMAT and IMPT.ConclusionsBgRT has the potential to reduce the radiation dose to proximal critical structures but requires further detailed investigation. |
| first_indexed | 2024-04-11T09:31:41Z |
| format | Article |
| id | doaj.art-d124dc2cb57b42aeacff0a31835a0914 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T09:31:41Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-d124dc2cb57b42aeacff0a31835a09142022-12-22T04:31:53ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-10-011210.3389/fonc.2022.921473921473The potential of biology-guided radiation therapy in thoracic cancer: A preliminary treatment planning studySteven N. Seyedin0Rostem Bassalow1Osama R. Mawlawi2Lehendrick M. Turner3Roshal R. Patel4Samuel R. Mazin5Oluwaseyi M. Oderinde6Yevgen Voronenko7Cody A. Wages8Peter D. Olcott9Joe Y. Chang10Peter A. Balter11James W. Welsh12Department of Radiation Oncology, University of California, Irvine-Chao Family Comprehensive Cancer Center, Orange, CA, United StatesNorthwest Medical Physics Center, Lynnwood, WA, United StatesDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesRefleXion Medical, Hayward, CA, United StatesRefleXion Medical, Hayward, CA, United StatesRefleXion Medical, Hayward, CA, United StatesDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesRefleXion Medical, Hayward, CA, United StatesDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesPurposeWe investigated the feasibility of biology-guided radiotherapy (BgRT), a technique that utilizes real-time positron emission imaging to minimize tumor motion uncertainties, to spare nearby organs at risk.MethodsVolumetric modulated arc therapy (VMAT), intensity-modulated proton (IMPT) therapy, and BgRT plans were created for a paratracheal node recurrence (case 1; 60 Gy in 10 fractions) and a primary peripheral left upper lobe adenocarcinoma (case 2; 50 Gy in four fractions).ResultsFor case 1, BgRT produced lower bronchus V40 values compared to VMAT and IMPT. For case 2, total lung V20 was lower in the BgRT case compared to VMAT and IMPT.ConclusionsBgRT has the potential to reduce the radiation dose to proximal critical structures but requires further detailed investigation.https://www.frontiersin.org/articles/10.3389/fonc.2022.921473/fullradiation therapystereotactic radiotherapythoracic cancerBgRTPET guidance |
| spellingShingle | Steven N. Seyedin Rostem Bassalow Osama R. Mawlawi Lehendrick M. Turner Roshal R. Patel Samuel R. Mazin Oluwaseyi M. Oderinde Yevgen Voronenko Cody A. Wages Peter D. Olcott Joe Y. Chang Peter A. Balter James W. Welsh The potential of biology-guided radiation therapy in thoracic cancer: A preliminary treatment planning study Frontiers in Oncology radiation therapy stereotactic radiotherapy thoracic cancer BgRT PET guidance |
| title | The potential of biology-guided radiation therapy in thoracic cancer: A preliminary treatment planning study |
| title_full | The potential of biology-guided radiation therapy in thoracic cancer: A preliminary treatment planning study |
| title_fullStr | The potential of biology-guided radiation therapy in thoracic cancer: A preliminary treatment planning study |
| title_full_unstemmed | The potential of biology-guided radiation therapy in thoracic cancer: A preliminary treatment planning study |
| title_short | The potential of biology-guided radiation therapy in thoracic cancer: A preliminary treatment planning study |
| title_sort | potential of biology guided radiation therapy in thoracic cancer a preliminary treatment planning study |
| topic | radiation therapy stereotactic radiotherapy thoracic cancer BgRT PET guidance |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.921473/full |
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