Neural Predictors of the Antidepressant Placebo Response
The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates. This manuscript reviews recent neuroimaging studies that aim to identify the neural signature of an...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-10-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/12/4/158 |
| _version_ | 1818295381271773184 |
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| author | Danielle Rette Erin McDonald Dan V. Iosifescu Katherine A. Collins |
| author_facet | Danielle Rette Erin McDonald Dan V. Iosifescu Katherine A. Collins |
| author_sort | Danielle Rette |
| collection | DOAJ |
| description | The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates. This manuscript reviews recent neuroimaging studies that aim to identify the neural signature of antidepressant placebo response. Data captured in clinical trials have primarily focused on antidepressant efficacy or predicting antidepressant response and have reliably implicated the rostral anterior cingulate cortex (rACC) in antidepressant placebo response, but also in medication response. Imaging and electroencephalography (EEG) experiments specifically interrogating the mechanism of antidepressant placebo response, while few, suggest the reward network, including opiate neurotransmission, is also involved. Therefore, while the rACC is likely involved in the antidepressant placebo response, its observation in isolation is unlikely to prospectively distinguish antidepressant placebo from medication responders. Instead, future studies of antidepressant placebo response should probe the reward network as a whole and incorporate sophisticated computational analytical approaches. |
| first_indexed | 2024-12-13T03:46:44Z |
| format | Article |
| id | doaj.art-d1281523f3cb4f669c361cb45937bfd8 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-12-13T03:46:44Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-d1281523f3cb4f669c361cb45937bfd82022-12-22T00:00:48ZengMDPI AGPharmaceuticals1424-82472019-10-0112415810.3390/ph12040158ph12040158Neural Predictors of the Antidepressant Placebo ResponseDanielle Rette0Erin McDonald1Dan V. Iosifescu2Katherine A. Collins3Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USANathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USANathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USANathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USAThe antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates. This manuscript reviews recent neuroimaging studies that aim to identify the neural signature of antidepressant placebo response. Data captured in clinical trials have primarily focused on antidepressant efficacy or predicting antidepressant response and have reliably implicated the rostral anterior cingulate cortex (rACC) in antidepressant placebo response, but also in medication response. Imaging and electroencephalography (EEG) experiments specifically interrogating the mechanism of antidepressant placebo response, while few, suggest the reward network, including opiate neurotransmission, is also involved. Therefore, while the rACC is likely involved in the antidepressant placebo response, its observation in isolation is unlikely to prospectively distinguish antidepressant placebo from medication responders. Instead, future studies of antidepressant placebo response should probe the reward network as a whole and incorporate sophisticated computational analytical approaches.https://www.mdpi.com/1424-8247/12/4/158placebo responseantidepressantneural predictors |
| spellingShingle | Danielle Rette Erin McDonald Dan V. Iosifescu Katherine A. Collins Neural Predictors of the Antidepressant Placebo Response Pharmaceuticals placebo response antidepressant neural predictors |
| title | Neural Predictors of the Antidepressant Placebo Response |
| title_full | Neural Predictors of the Antidepressant Placebo Response |
| title_fullStr | Neural Predictors of the Antidepressant Placebo Response |
| title_full_unstemmed | Neural Predictors of the Antidepressant Placebo Response |
| title_short | Neural Predictors of the Antidepressant Placebo Response |
| title_sort | neural predictors of the antidepressant placebo response |
| topic | placebo response antidepressant neural predictors |
| url | https://www.mdpi.com/1424-8247/12/4/158 |
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