The role of cancer-associated fibroblasts in bladder cancer progression
Cancer-associated fibroblasts (CAFs) are key stromal cells in the tumor microenvironment (TME) that critically contribute to cancer initiation and progression. In bladder cancer (BCa), there is emerging evidence that BCa CAFs are actively involved in cancer cell proliferation, invasion, metastasis,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402307010X |
| _version_ | 1797669797491638272 |
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| author | Long Huang Qun Xie Jian Deng Wen-Fei Wei |
| author_facet | Long Huang Qun Xie Jian Deng Wen-Fei Wei |
| author_sort | Long Huang |
| collection | DOAJ |
| description | Cancer-associated fibroblasts (CAFs) are key stromal cells in the tumor microenvironment (TME) that critically contribute to cancer initiation and progression. In bladder cancer (BCa), there is emerging evidence that BCa CAFs are actively involved in cancer cell proliferation, invasion, metastasis, and chemotherapy resistance. This review outlines the present knowledge of BCa CAFs, with a particular emphasis on their origin and function in BCa progression, and provides further insights into their clinical application. |
| first_indexed | 2024-03-11T20:49:59Z |
| format | Article |
| id | doaj.art-d12864a5e950487e8d6e06c02aba2570 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-11T20:49:59Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-d12864a5e950487e8d6e06c02aba25702023-10-01T06:01:19ZengElsevierHeliyon2405-84402023-09-0199e19802The role of cancer-associated fibroblasts in bladder cancer progressionLong Huang0Qun Xie1Jian Deng2Wen-Fei Wei3Department of Urology, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, Guangdong, ChinaDepartment of Urology, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, Guangdong, ChinaDepartment of Urology, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, Guangdong, China; Corresponding author.Department of Gynecology, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, Guangdong, China; Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China; Corresponding author. Department of Gynecology, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, Guangdong, China.Cancer-associated fibroblasts (CAFs) are key stromal cells in the tumor microenvironment (TME) that critically contribute to cancer initiation and progression. In bladder cancer (BCa), there is emerging evidence that BCa CAFs are actively involved in cancer cell proliferation, invasion, metastasis, and chemotherapy resistance. This review outlines the present knowledge of BCa CAFs, with a particular emphasis on their origin and function in BCa progression, and provides further insights into their clinical application.http://www.sciencedirect.com/science/article/pii/S240584402307010XBladder cancerCancer-associated fibroblastsProliferationInvasion and metastasisChemotherapy resistance |
| spellingShingle | Long Huang Qun Xie Jian Deng Wen-Fei Wei The role of cancer-associated fibroblasts in bladder cancer progression Heliyon Bladder cancer Cancer-associated fibroblasts Proliferation Invasion and metastasis Chemotherapy resistance |
| title | The role of cancer-associated fibroblasts in bladder cancer progression |
| title_full | The role of cancer-associated fibroblasts in bladder cancer progression |
| title_fullStr | The role of cancer-associated fibroblasts in bladder cancer progression |
| title_full_unstemmed | The role of cancer-associated fibroblasts in bladder cancer progression |
| title_short | The role of cancer-associated fibroblasts in bladder cancer progression |
| title_sort | role of cancer associated fibroblasts in bladder cancer progression |
| topic | Bladder cancer Cancer-associated fibroblasts Proliferation Invasion and metastasis Chemotherapy resistance |
| url | http://www.sciencedirect.com/science/article/pii/S240584402307010X |
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