17O-labeled water distribution in the human inner ear: Insights into lymphatic dynamics and vestibular function
We evaluated the inner ear distribution of 17O-labeled saline administered to the human tympanic cavity. Magnetic resonance imaging was performed after intratympanic administration in five healthy volunteers and one patient with cochlear endolymphatic hydrops. In all volunteers, 17O-labeled water pe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.1016577/full |
| _version_ | 1811193194147217408 |
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| author | Tadao Yoshida Shinji Naganawa Masumi Kobayashi Satofumi Sugimoto Naomi Katayama Tsutomu Nakashima Yutaka Kato Kazushige Ichikawa Hiroshi Yamaguchi Kazuki Nishida Michihiko Sone |
| author_facet | Tadao Yoshida Shinji Naganawa Masumi Kobayashi Satofumi Sugimoto Naomi Katayama Tsutomu Nakashima Yutaka Kato Kazushige Ichikawa Hiroshi Yamaguchi Kazuki Nishida Michihiko Sone |
| author_sort | Tadao Yoshida |
| collection | DOAJ |
| description | We evaluated the inner ear distribution of 17O-labeled saline administered to the human tympanic cavity. Magnetic resonance imaging was performed after intratympanic administration in five healthy volunteers and one patient with cochlear endolymphatic hydrops. In all volunteers, 17O-labeled water permeated the cochlear basal turn and vestibule at 30 min and disappeared gradually within 2–4 h. All participants experienced positional vertigo lasting a few hours to a few days. Visualization of 17O-labeled water distribution in the endolymphatic space of the posterior ampulla showed indistinct separation of endolymph and perilymph in the cochlea and most of the vestibule in all participants. Intralabyrinthine distribution of 17O-labeled water differed from that in previous reports of intratympanically administered gadolinium-based contrast agent. 17O-labeled water in the endolymphatic space may cause heavier endolymph and positional vertigo. These results of this study may add new insights for investigating the distribution and the effects of molecules in the inner ear after the intratympanic administration in living humans. |
| first_indexed | 2024-04-12T00:04:27Z |
| format | Article |
| id | doaj.art-d129f5e39efb4a9ab6c10809b2c7e21e |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T00:04:27Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-d129f5e39efb4a9ab6c10809b2c7e21e2022-12-22T03:56:09ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-11-011310.3389/fneur.2022.1016577101657717O-labeled water distribution in the human inner ear: Insights into lymphatic dynamics and vestibular functionTadao Yoshida0Shinji Naganawa1Masumi Kobayashi2Satofumi Sugimoto3Naomi Katayama4Tsutomu Nakashima5Yutaka Kato6Kazushige Ichikawa7Hiroshi Yamaguchi8Kazuki Nishida9Michihiko Sone10Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, JapanDepartment of Radiology, Nagoya University Graduate School of Medicine, Nagoya, JapanDepartment of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, JapanDepartment of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, JapanDepartment of Health and Nutrition, Faculty of Health and Sciences, Nagoya Women's University, Nagoya, JapanDepartment of Rehabilitation, Ichinomiya Medical Treatment and Habilitation Center, Ichinomiya, JapanDepartment of Radiological Technology, Nagoya University Hospital, Nagoya, JapanDepartment of Radiological Technology, Nagoya University Hospital, Nagoya, JapanMedical Branch of Radioisotope Research Center, Nagoya University, Nagoya, JapanDepartment of Biostatistics Section, Center for Advanced Medicine and Clinical Research, Nagoya University Graduate School of Medicine, Nagoya, JapanDepartment of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, JapanWe evaluated the inner ear distribution of 17O-labeled saline administered to the human tympanic cavity. Magnetic resonance imaging was performed after intratympanic administration in five healthy volunteers and one patient with cochlear endolymphatic hydrops. In all volunteers, 17O-labeled water permeated the cochlear basal turn and vestibule at 30 min and disappeared gradually within 2–4 h. All participants experienced positional vertigo lasting a few hours to a few days. Visualization of 17O-labeled water distribution in the endolymphatic space of the posterior ampulla showed indistinct separation of endolymph and perilymph in the cochlea and most of the vestibule in all participants. Intralabyrinthine distribution of 17O-labeled water differed from that in previous reports of intratympanically administered gadolinium-based contrast agent. 17O-labeled water in the endolymphatic space may cause heavier endolymph and positional vertigo. These results of this study may add new insights for investigating the distribution and the effects of molecules in the inner ear after the intratympanic administration in living humans.https://www.frontiersin.org/articles/10.3389/fneur.2022.1016577/full17O-labeled waterMRIperilymphendolymphvertigo |
| spellingShingle | Tadao Yoshida Shinji Naganawa Masumi Kobayashi Satofumi Sugimoto Naomi Katayama Tsutomu Nakashima Yutaka Kato Kazushige Ichikawa Hiroshi Yamaguchi Kazuki Nishida Michihiko Sone 17O-labeled water distribution in the human inner ear: Insights into lymphatic dynamics and vestibular function Frontiers in Neurology 17O-labeled water MRI perilymph endolymph vertigo |
| title | 17O-labeled water distribution in the human inner ear: Insights into lymphatic dynamics and vestibular function |
| title_full | 17O-labeled water distribution in the human inner ear: Insights into lymphatic dynamics and vestibular function |
| title_fullStr | 17O-labeled water distribution in the human inner ear: Insights into lymphatic dynamics and vestibular function |
| title_full_unstemmed | 17O-labeled water distribution in the human inner ear: Insights into lymphatic dynamics and vestibular function |
| title_short | 17O-labeled water distribution in the human inner ear: Insights into lymphatic dynamics and vestibular function |
| title_sort | 17o labeled water distribution in the human inner ear insights into lymphatic dynamics and vestibular function |
| topic | 17O-labeled water MRI perilymph endolymph vertigo |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.1016577/full |
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