Hypoxia-induced miR-181a-5p up-regulation reduces epirubicin sensitivity in breast cancer cells through inhibiting EPDR1/TRPC1 to activate PI3K/AKT signaling pathway

Hypoxia-induced miR-181a-5p up-regulation reduces epirubicin sensitivity in breast cancer cells through inhibiting EPDR1/TRPC1 to activate PI3K/AKT signaling pathway

Abstract Breast carcinoma (BC) ranks as a predominant malignancy and constitutes the second principal cause of mortality among women globally. Epirubicin stands as the drug of choice for BC therapeutics. Nevertheless, the emergence of chemoresistance has significantly curtailed its therapeutic effic...

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Bibliographic Details
Main Authors: Yunwei Zhang, Yunping Guan, Xinyu Zheng, Chenyang Li
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Cancer
Subjects:
Breast cancer
miR-181a-5p
Hypoxia
Epirubicin
EPDR1
Online Access:https://doi.org/10.1186/s12885-024-11906-6

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