Vaccination against hepatitis A virus may not be required for schoolchildren in northern India: results of a seroepidemiological survey
OBJECTIVES: To evaluate the current seroprevalence of antibodies against hepatitis A virus (HAV) in a sample of schoolchildren above 10 years of age and to determine the prevalence of HAV-induced hepatitis in adults at a tertiary care hospital in northern India between January 1992 and December 2000...
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| Language: | English |
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The World Health Organization
2002-01-01
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| Series: | Bulletin of the World Health Organization |
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| Online Access: | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0042-96862002000900009 |
| _version_ | 1797287659783061504 |
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| author | Batra Yogesh Bhatkal Bharati Ojha Bandana Kaur Kuldeep Saraya Anoop Panda Subrat Kumar Acharya Subrat Kumar |
| author_facet | Batra Yogesh Bhatkal Bharati Ojha Bandana Kaur Kuldeep Saraya Anoop Panda Subrat Kumar Acharya Subrat Kumar |
| author_sort | Batra Yogesh |
| collection | DOAJ |
| description | OBJECTIVES: To evaluate the current seroprevalence of antibodies against hepatitis A virus (HAV) in a sample of schoolchildren above 10 years of age and to determine the prevalence of HAV-induced hepatitis in adults at a tertiary care hospital in northern India between January 1992 and December 2000. METHODS: Sera from 276 male and 224 female schoolchildren aged 10-17 years were tested for anti-HAV antibodies by enzyme-linked immunosorbent assay. Consecutive patients with a diagnosis of acute viral hepatitis who attended a liver clinic were tested for the serological markers of HAV, hepatitis B Virus, hepatitis C virus, hepatitis D virus, and hepatitis E virus. FINDINGS: Of the male and female children, 96.3% and 98.2%, respectively had anti-HAV antibodies in their sera. The prevalence of these antibodies in the age groups 10-12, 13- 14, and 15-17 years were 98.6%, 94.8%, and 98.3% respectively. The frequency of HAV- induced acute viral hepatitis (69/870, 8%) in adults did not show an increasing trend. CONCLUSION: Mass HAV vaccination may be unnecessary in northern India because the seroprevalence of protective antibodies against HAV in schoolchildren aged over 10 years remains above 95% and there has been no apparent increase in HAV-induced acute viral hepatitis in adults. |
| first_indexed | 2024-03-07T18:37:38Z |
| format | Article |
| id | doaj.art-d12be59b62704cbd88821b85a8c48b39 |
| institution | Directory Open Access Journal |
| issn | 0042-9686 |
| language | English |
| last_indexed | 2024-03-07T18:37:38Z |
| publishDate | 2002-01-01 |
| publisher | The World Health Organization |
| record_format | Article |
| series | Bulletin of the World Health Organization |
| spelling | doaj.art-d12be59b62704cbd88821b85a8c48b392024-03-02T04:48:21ZengThe World Health OrganizationBulletin of the World Health Organization0042-96862002-01-01809728731Vaccination against hepatitis A virus may not be required for schoolchildren in northern India: results of a seroepidemiological surveyBatra YogeshBhatkal BharatiOjha BandanaKaur KuldeepSaraya AnoopPanda Subrat KumarAcharya Subrat KumarOBJECTIVES: To evaluate the current seroprevalence of antibodies against hepatitis A virus (HAV) in a sample of schoolchildren above 10 years of age and to determine the prevalence of HAV-induced hepatitis in adults at a tertiary care hospital in northern India between January 1992 and December 2000. METHODS: Sera from 276 male and 224 female schoolchildren aged 10-17 years were tested for anti-HAV antibodies by enzyme-linked immunosorbent assay. Consecutive patients with a diagnosis of acute viral hepatitis who attended a liver clinic were tested for the serological markers of HAV, hepatitis B Virus, hepatitis C virus, hepatitis D virus, and hepatitis E virus. FINDINGS: Of the male and female children, 96.3% and 98.2%, respectively had anti-HAV antibodies in their sera. The prevalence of these antibodies in the age groups 10-12, 13- 14, and 15-17 years were 98.6%, 94.8%, and 98.3% respectively. The frequency of HAV- induced acute viral hepatitis (69/870, 8%) in adults did not show an increasing trend. CONCLUSION: Mass HAV vaccination may be unnecessary in northern India because the seroprevalence of protective antibodies against HAV in schoolchildren aged over 10 years remains above 95% and there has been no apparent increase in HAV-induced acute viral hepatitis in adults.http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0042-96862002000900009Hepatovirus/immunologyHepatitis antibodies/immunologyHepatitis B surface antigensHepatitisViral, Human/virologyChildAdultSeroepidemiologic studiesIndia |
| spellingShingle | Batra Yogesh Bhatkal Bharati Ojha Bandana Kaur Kuldeep Saraya Anoop Panda Subrat Kumar Acharya Subrat Kumar Vaccination against hepatitis A virus may not be required for schoolchildren in northern India: results of a seroepidemiological survey Bulletin of the World Health Organization Hepatovirus/immunology Hepatitis antibodies/immunology Hepatitis B surface antigens Hepatitis Viral, Human/virology Child Adult Seroepidemiologic studies India |
| title | Vaccination against hepatitis A virus may not be required for schoolchildren in northern India: results of a seroepidemiological survey |
| title_full | Vaccination against hepatitis A virus may not be required for schoolchildren in northern India: results of a seroepidemiological survey |
| title_fullStr | Vaccination against hepatitis A virus may not be required for schoolchildren in northern India: results of a seroepidemiological survey |
| title_full_unstemmed | Vaccination against hepatitis A virus may not be required for schoolchildren in northern India: results of a seroepidemiological survey |
| title_short | Vaccination against hepatitis A virus may not be required for schoolchildren in northern India: results of a seroepidemiological survey |
| title_sort | vaccination against hepatitis a virus may not be required for schoolchildren in northern india results of a seroepidemiological survey |
| topic | Hepatovirus/immunology Hepatitis antibodies/immunology Hepatitis B surface antigens Hepatitis Viral, Human/virology Child Adult Seroepidemiologic studies India |
| url | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0042-96862002000900009 |
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