Graphene Quantum Dots from Carbonized Coffee Bean Wastes for Biomedical Applications
Recent studies concerning graphene quantum dots (GQDs) focus extensively on their application in biomedicine, exploiting their modifiable optical properties and ability to complex with various molecules via π–π or covalent interactions. Among these nascent findings, the potential therapeutic efficac...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/6/1423 |
| _version_ | 1797532286454857728 |
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| author | Dong Jin Kim Je Min Yoo Yeonjoon Suh Donghoon Kim Insung Kang Joonhee Moon Mina Park Juhee Kim Kyung-Sun Kang Byung Hee Hong |
| author_facet | Dong Jin Kim Je Min Yoo Yeonjoon Suh Donghoon Kim Insung Kang Joonhee Moon Mina Park Juhee Kim Kyung-Sun Kang Byung Hee Hong |
| author_sort | Dong Jin Kim |
| collection | DOAJ |
| description | Recent studies concerning graphene quantum dots (GQDs) focus extensively on their application in biomedicine, exploiting their modifiable optical properties and ability to complex with various molecules via π–π or covalent interactions. Among these nascent findings, the potential therapeutic efficacy of GQDs was reported against Parkinson’s disease, which has to date remained incurable. Herein, we present an environmentally friendly approach for synthesizing GQDs through a waste-to-treasure method, specifically from coffee waste to nanodrug. Consistent with the previous findings with carbon fiber-derived GQDs, the inhibitory effects of coffee bean-derived GQDs demonstrated similar effectiveness against abnormal α-synuclein fibrillation and the protection of neurons from relevant subcellular damages. The fact that a GQDs-based nanodrug can be prepared from a non-reusable yet edible source illustrates a potential approach to convert such waste materials into novel therapeutic agents with minimal psychological rejection by patients. |
| first_indexed | 2024-03-10T10:56:58Z |
| format | Article |
| id | doaj.art-d12de40ec0a949b0816b02c3c065c2bf |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T10:56:58Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-d12de40ec0a949b0816b02c3c065c2bf2023-11-21T21:48:45ZengMDPI AGNanomaterials2079-49912021-05-01116142310.3390/nano11061423Graphene Quantum Dots from Carbonized Coffee Bean Wastes for Biomedical ApplicationsDong Jin Kim0Je Min Yoo1Yeonjoon Suh2Donghoon Kim3Insung Kang4Joonhee Moon5Mina Park6Juhee Kim7Kyung-Sun Kang8Byung Hee Hong9Program in Nano Science and Technology, Graduate school of Convergence Science and Technology, Seoul National University, Seoul 08826, KoreaDepartment of Chemistry, Seoul National University, Seoul 08826, KoreaGraphene Research Center, Advanced Institute of Convergence Technology, Suwon 16229, KoreaBIOGRAPHENE, Los Angeles, CA 90013, USAAdult Stem Cell Research Center and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, KoreaDivision of Analytical Science Research, Korea Basic Science Institute (KBSI) Daejeon 34133, KoreaDepartment of Chemistry, Seoul National University, Seoul 08826, KoreaDepartment of Chemistry, Seoul National University, Seoul 08826, KoreaAdult Stem Cell Research Center and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, KoreaGraphene Research Center, Advanced Institute of Convergence Technology, Suwon 16229, KoreaRecent studies concerning graphene quantum dots (GQDs) focus extensively on their application in biomedicine, exploiting their modifiable optical properties and ability to complex with various molecules via π–π or covalent interactions. Among these nascent findings, the potential therapeutic efficacy of GQDs was reported against Parkinson’s disease, which has to date remained incurable. Herein, we present an environmentally friendly approach for synthesizing GQDs through a waste-to-treasure method, specifically from coffee waste to nanodrug. Consistent with the previous findings with carbon fiber-derived GQDs, the inhibitory effects of coffee bean-derived GQDs demonstrated similar effectiveness against abnormal α-synuclein fibrillation and the protection of neurons from relevant subcellular damages. The fact that a GQDs-based nanodrug can be prepared from a non-reusable yet edible source illustrates a potential approach to convert such waste materials into novel therapeutic agents with minimal psychological rejection by patients.https://www.mdpi.com/2079-4991/11/6/1423graphenegraphene quantum dotsnanomedicineParkinson’s disease |
| spellingShingle | Dong Jin Kim Je Min Yoo Yeonjoon Suh Donghoon Kim Insung Kang Joonhee Moon Mina Park Juhee Kim Kyung-Sun Kang Byung Hee Hong Graphene Quantum Dots from Carbonized Coffee Bean Wastes for Biomedical Applications Nanomaterials graphene graphene quantum dots nanomedicine Parkinson’s disease |
| title | Graphene Quantum Dots from Carbonized Coffee Bean Wastes for Biomedical Applications |
| title_full | Graphene Quantum Dots from Carbonized Coffee Bean Wastes for Biomedical Applications |
| title_fullStr | Graphene Quantum Dots from Carbonized Coffee Bean Wastes for Biomedical Applications |
| title_full_unstemmed | Graphene Quantum Dots from Carbonized Coffee Bean Wastes for Biomedical Applications |
| title_short | Graphene Quantum Dots from Carbonized Coffee Bean Wastes for Biomedical Applications |
| title_sort | graphene quantum dots from carbonized coffee bean wastes for biomedical applications |
| topic | graphene graphene quantum dots nanomedicine Parkinson’s disease |
| url | https://www.mdpi.com/2079-4991/11/6/1423 |
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