A Mycobacterium avium subsp. paratuberculosis relA deletion mutant and a 35 kDa major membrane protein elicit development of cytotoxic T lymphocytes with ability to kill intracellular bacteria

A Mycobacterium avium subsp. paratuberculosis relA deletion mutant and a 35 kDa major membrane protein elicit development of cytotoxic T lymphocytes with ability to kill intracellular bacteria

Abstract Efforts to develop live attenuated vaccines against Mycobacterium avium subspecies paratuberculosis (Map), using indirect methods to screen Map deletion mutants for potential efficacy, have not been successful. A reduction in the capacity to survive in macrophages has not predicted the abil...

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Detalles Bibliográficos
Main Authors: Gaber S. Abdellrazeq, Mahmoud M. Elnaggar, John P. Bannantine, Kun T. Park, Cleverson D. Souza, Brian Backer, Victoria Hulubei, Lindsay M. Fry, Samy A. Khaliel, Helmy A. Torky, David A. Schneider, William C. Davis
Formato: Artigo
Idioma:English
Publicado: BMC 2018-06-01
Series:Veterinary Research
Acceso en liña:http://link.springer.com/article/10.1186/s13567-018-0549-3

Internet

http://link.springer.com/article/10.1186/s13567-018-0549-3

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