Feasibility of Recombinant Human TSH as a Preparation for Radioiodine Therapy in Patients with Distant Metastases from Papillary Thyroid Cancer: Comparison of Long-Term Survival Outcomes with Thyroid Hormone Withdrawal
Background: this study was designed to compare the long-term survival outcomes of patients prepared for radioiodine (RAI) therapy using either thyroid hormone withdrawal (THW) or recombinant human thyrotropin (rhTSH) stimulation, by specifically focusing on cases with distant metastases from papilla...
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MDPI AG
2022-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/1/221 |
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| author | Hsi-Chen Tsai Kung-Chu Ho Shih-Hsin Chen Jing-Ren Tseng Lan-Yan Yang Kun-Ju Lin Ju-Chin Cheng Miaw-Jene Liou |
| author_facet | Hsi-Chen Tsai Kung-Chu Ho Shih-Hsin Chen Jing-Ren Tseng Lan-Yan Yang Kun-Ju Lin Ju-Chin Cheng Miaw-Jene Liou |
| author_sort | Hsi-Chen Tsai |
| collection | DOAJ |
| description | Background: this study was designed to compare the long-term survival outcomes of patients prepared for radioiodine (RAI) therapy using either thyroid hormone withdrawal (THW) or recombinant human thyrotropin (rhTSH) stimulation, by specifically focusing on cases with distant metastases from papillary thyroid cancer (PTC). Methods: A retrospective analysis was performed on 88 patients with distant metastases from PTC. Fifty-one and thirty-seven patients were prepared for RAI treatment by either THW or rhTSH stimulation, respectively. The primary endpoints were progression-free survival (PFS) and disease-specific survival (DSS). Results: The 10-year DSS rates of patients prepared for RAI therapy using either THW or rhTSH stimulation were 62.2% and 73.3%, respectively. Using multivariate analysis, RAI-avid metastases (<i>p</i> = 0.025) and preparation with rhTSH (<i>p</i> = 0.041) were identified as independent prognostic factors for PFS. Notably, PFS in the group of patients with RAI-avid metastases and preparation with rhTSH was significantly better than that in the other groups (<i>p</i> = 0.025). Conclusions: Preparation for RAI therapy using rhTSH stimulation is not inferior to THW preparation in terms of long-term survival outcomes experienced by patients with PTC and distant metastasis. Patients with RAI-avid metastases and preparation with rhTSH had the most favorable PFS. |
| first_indexed | 2024-03-10T01:37:50Z |
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| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T01:37:50Z |
| publishDate | 2022-01-01 |
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| series | Diagnostics |
| spelling | doaj.art-d12eee0f48d6459ea764776ebddc55932023-11-23T13:30:20ZengMDPI AGDiagnostics2075-44182022-01-0112122110.3390/diagnostics12010221Feasibility of Recombinant Human TSH as a Preparation for Radioiodine Therapy in Patients with Distant Metastases from Papillary Thyroid Cancer: Comparison of Long-Term Survival Outcomes with Thyroid Hormone WithdrawalHsi-Chen Tsai0Kung-Chu Ho1Shih-Hsin Chen2Jing-Ren Tseng3Lan-Yan Yang4Kun-Ju Lin5Ju-Chin Cheng6Miaw-Jene Liou7Department of Nuclear Medicine, New Taipei Municipal TuCheng Hospital (Built and Operated by Chang Gung Medical Foundation), New Taipei 236, TaiwanDepartment of Nuclear Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDepartment of Nuclear Medicine, Keelung Chang Gung Memorial Hospital, Keelung 204, TaiwanDepartment of Nuclear Medicine, New Taipei Municipal TuCheng Hospital (Built and Operated by Chang Gung Medical Foundation), New Taipei 236, TaiwanBiostatistics Unit, Clinical Trial Center, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDepartment of Nuclear Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDepartment of Nuclear Medicine, Keelung Chang Gung Memorial Hospital, Keelung 204, TaiwanDepartment of Metabolism and Endocrinology, Linkou Chang Gung Memorial Hospital, Taoyuan 333, TaiwanBackground: this study was designed to compare the long-term survival outcomes of patients prepared for radioiodine (RAI) therapy using either thyroid hormone withdrawal (THW) or recombinant human thyrotropin (rhTSH) stimulation, by specifically focusing on cases with distant metastases from papillary thyroid cancer (PTC). Methods: A retrospective analysis was performed on 88 patients with distant metastases from PTC. Fifty-one and thirty-seven patients were prepared for RAI treatment by either THW or rhTSH stimulation, respectively. The primary endpoints were progression-free survival (PFS) and disease-specific survival (DSS). Results: The 10-year DSS rates of patients prepared for RAI therapy using either THW or rhTSH stimulation were 62.2% and 73.3%, respectively. Using multivariate analysis, RAI-avid metastases (<i>p</i> = 0.025) and preparation with rhTSH (<i>p</i> = 0.041) were identified as independent prognostic factors for PFS. Notably, PFS in the group of patients with RAI-avid metastases and preparation with rhTSH was significantly better than that in the other groups (<i>p</i> = 0.025). Conclusions: Preparation for RAI therapy using rhTSH stimulation is not inferior to THW preparation in terms of long-term survival outcomes experienced by patients with PTC and distant metastasis. Patients with RAI-avid metastases and preparation with rhTSH had the most favorable PFS.https://www.mdpi.com/2075-4418/12/1/221papillary thyroid cancerdistant metastasisradioiodine therapythyroid hormone withdrawalrecombinant human TSH stimulation |
| spellingShingle | Hsi-Chen Tsai Kung-Chu Ho Shih-Hsin Chen Jing-Ren Tseng Lan-Yan Yang Kun-Ju Lin Ju-Chin Cheng Miaw-Jene Liou Feasibility of Recombinant Human TSH as a Preparation for Radioiodine Therapy in Patients with Distant Metastases from Papillary Thyroid Cancer: Comparison of Long-Term Survival Outcomes with Thyroid Hormone Withdrawal Diagnostics papillary thyroid cancer distant metastasis radioiodine therapy thyroid hormone withdrawal recombinant human TSH stimulation |
| title | Feasibility of Recombinant Human TSH as a Preparation for Radioiodine Therapy in Patients with Distant Metastases from Papillary Thyroid Cancer: Comparison of Long-Term Survival Outcomes with Thyroid Hormone Withdrawal |
| title_full | Feasibility of Recombinant Human TSH as a Preparation for Radioiodine Therapy in Patients with Distant Metastases from Papillary Thyroid Cancer: Comparison of Long-Term Survival Outcomes with Thyroid Hormone Withdrawal |
| title_fullStr | Feasibility of Recombinant Human TSH as a Preparation for Radioiodine Therapy in Patients with Distant Metastases from Papillary Thyroid Cancer: Comparison of Long-Term Survival Outcomes with Thyroid Hormone Withdrawal |
| title_full_unstemmed | Feasibility of Recombinant Human TSH as a Preparation for Radioiodine Therapy in Patients with Distant Metastases from Papillary Thyroid Cancer: Comparison of Long-Term Survival Outcomes with Thyroid Hormone Withdrawal |
| title_short | Feasibility of Recombinant Human TSH as a Preparation for Radioiodine Therapy in Patients with Distant Metastases from Papillary Thyroid Cancer: Comparison of Long-Term Survival Outcomes with Thyroid Hormone Withdrawal |
| title_sort | feasibility of recombinant human tsh as a preparation for radioiodine therapy in patients with distant metastases from papillary thyroid cancer comparison of long term survival outcomes with thyroid hormone withdrawal |
| topic | papillary thyroid cancer distant metastasis radioiodine therapy thyroid hormone withdrawal recombinant human TSH stimulation |
| url | https://www.mdpi.com/2075-4418/12/1/221 |
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