Pulmonary alveolar proteinosis in Korea: analysis of prevalence and incidence via a nationwide population-based study
Abstract Background Pulmonary alveolar proteinosis (PAP) is a very rare lung disease and its prevalence and incidence remain unclear. The prevalence and incidence of PAP were investigated by using nationwide claims data from the Korean Health Insurance Review and Assessment service. Methods Data wer...
| Үндсэн зохиолчид: | , , , |
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| Формат: | Өгүүллэг |
| Хэл сонгох: | English |
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BMC
2020-02-01
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| Цуврал: | BMC Pulmonary Medicine |
| Нөхцлүүд: | |
| Онлайн хандалт: | https://doi.org/10.1186/s12890-020-1074-5 |
| _version_ | 1829521127646429184 |
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| author | Hee-young Yoon Ji Hyeon Kim Ye-Jee Kim Jin Woo Song |
| author_facet | Hee-young Yoon Ji Hyeon Kim Ye-Jee Kim Jin Woo Song |
| author_sort | Hee-young Yoon |
| collection | DOAJ |
| description | Abstract Background Pulmonary alveolar proteinosis (PAP) is a very rare lung disease and its prevalence and incidence remain unclear. The prevalence and incidence of PAP were investigated by using nationwide claims data from the Korean Health Insurance Review and Assessment service. Methods Data were extracted for adults who visited any secondary or tertiary medical institute between 2010 and 2016 with the PAP-related Korean Classification of Disease, 7th edition code J84.0 and the Rare Intractable Disease exempted calculation code V222. To robust case definition, a narrow case definition was made when all following factors were met: 1) more than two PAP-coded visits within 1 year of the first claim, and 2) more than one claim for both chest computed tomography and diagnostic procedures (bronchoscopy or surgical lung biopsy) within 90 days before or after the first claim. Results A total of 182 patients (narrow, n = 82) with PAP-related codes were identified from 2010 to 2016 and 89 new patients (narrow, n = 66) visited medical institutes between 2012 and 2015. The prevalence of PAP was 4.44 (narrow: 2.27) per 106 population, with a peak age of 60–69 years. The incidence of PAP was 0.56 (narrow: 0.41) per 106 population at risk, with a peak age of 50–59 years. Among incident cases, the male-to-female ratio was 1.52 and about two-thirds had comorbidities, dyslipidaemia being the most common. Conclusions The prevalence and incidence of PAP in Korea are low, similar to those in other countries; however, Korean patients with PAP are characterized by older diagnostic age and a lower male-to-female ratio. |
| first_indexed | 2024-12-16T15:10:16Z |
| format | Article |
| id | doaj.art-d12f34d2492c4cb8aae09f99fa23dd6a |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-16T15:10:16Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-d12f34d2492c4cb8aae09f99fa23dd6a2022-12-21T22:26:59ZengBMCBMC Pulmonary Medicine1471-24662020-02-012011810.1186/s12890-020-1074-5Pulmonary alveolar proteinosis in Korea: analysis of prevalence and incidence via a nationwide population-based studyHee-young Yoon0Ji Hyeon Kim1Ye-Jee Kim2Jin Woo Song3Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Ewha Woman’s UniversityDepartment of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of MedicineDepartment of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of MedicineDepartment of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of MedicineAbstract Background Pulmonary alveolar proteinosis (PAP) is a very rare lung disease and its prevalence and incidence remain unclear. The prevalence and incidence of PAP were investigated by using nationwide claims data from the Korean Health Insurance Review and Assessment service. Methods Data were extracted for adults who visited any secondary or tertiary medical institute between 2010 and 2016 with the PAP-related Korean Classification of Disease, 7th edition code J84.0 and the Rare Intractable Disease exempted calculation code V222. To robust case definition, a narrow case definition was made when all following factors were met: 1) more than two PAP-coded visits within 1 year of the first claim, and 2) more than one claim for both chest computed tomography and diagnostic procedures (bronchoscopy or surgical lung biopsy) within 90 days before or after the first claim. Results A total of 182 patients (narrow, n = 82) with PAP-related codes were identified from 2010 to 2016 and 89 new patients (narrow, n = 66) visited medical institutes between 2012 and 2015. The prevalence of PAP was 4.44 (narrow: 2.27) per 106 population, with a peak age of 60–69 years. The incidence of PAP was 0.56 (narrow: 0.41) per 106 population at risk, with a peak age of 50–59 years. Among incident cases, the male-to-female ratio was 1.52 and about two-thirds had comorbidities, dyslipidaemia being the most common. Conclusions The prevalence and incidence of PAP in Korea are low, similar to those in other countries; however, Korean patients with PAP are characterized by older diagnostic age and a lower male-to-female ratio.https://doi.org/10.1186/s12890-020-1074-5EpidemiologyInsurance claim reviewHealth care surveyNational Health ProgramsRare diseases |
| spellingShingle | Hee-young Yoon Ji Hyeon Kim Ye-Jee Kim Jin Woo Song Pulmonary alveolar proteinosis in Korea: analysis of prevalence and incidence via a nationwide population-based study BMC Pulmonary Medicine Epidemiology Insurance claim review Health care survey National Health Programs Rare diseases |
| title | Pulmonary alveolar proteinosis in Korea: analysis of prevalence and incidence via a nationwide population-based study |
| title_full | Pulmonary alveolar proteinosis in Korea: analysis of prevalence and incidence via a nationwide population-based study |
| title_fullStr | Pulmonary alveolar proteinosis in Korea: analysis of prevalence and incidence via a nationwide population-based study |
| title_full_unstemmed | Pulmonary alveolar proteinosis in Korea: analysis of prevalence and incidence via a nationwide population-based study |
| title_short | Pulmonary alveolar proteinosis in Korea: analysis of prevalence and incidence via a nationwide population-based study |
| title_sort | pulmonary alveolar proteinosis in korea analysis of prevalence and incidence via a nationwide population based study |
| topic | Epidemiology Insurance claim review Health care survey National Health Programs Rare diseases |
| url | https://doi.org/10.1186/s12890-020-1074-5 |
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