Exercise training affects calcium ion transport by downregulating the CACNA2D1 protein to reduce hypertension-induced myocardial injury in mice
Summary: Hypertension is a risk factor for cardiovascular disease, and exercise has cardioprotective effects on the heart. However, the mechanism by which exercise affects hypertension-induced myocardial injury remains unclear. Exercise response model of hypertension-induced myocardial injury in mic...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224005728 |
| _version_ | 1797267211929255936 |
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| author | Shan Gao Wei Yao Rui Zhou Zuowei Pei |
| author_facet | Shan Gao Wei Yao Rui Zhou Zuowei Pei |
| author_sort | Shan Gao |
| collection | DOAJ |
| description | Summary: Hypertension is a risk factor for cardiovascular disease, and exercise has cardioprotective effects on the heart. However, the mechanism by which exercise affects hypertension-induced myocardial injury remains unclear. Exercise response model of hypertension-induced myocardial injury in mice was analyzed using multiomics data to identify potential factors. The study found that serum Ca2+ and brain natriuretic peptide concentrations were significantly higher in the HTN (hypertension) group than in the control, HTN+MICT (moderate intensity continuous exercise), and HTN+HIIT (high intensity intermittent exercise) groups. Cardiac tissue damage and fibrosis increased in the HTN group, but exercise training reduced pathological changes, with more improvement in the HTN+HIIT group. Transcriptomic and proteomic studies showed significant differences in CACNA2D1 expression between the different treatment groups. HIIT ameliorated HTN-induced myocardial injury in mice by decreasing Ca2+ concentration and diastolizing vascular smooth muscle by downregulating CACNA2D1 via exercise. |
| first_indexed | 2024-04-25T01:12:59Z |
| format | Article |
| id | doaj.art-d12fdf398b8e49e1b6eab216a2b08339 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-25T01:12:59Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-d12fdf398b8e49e1b6eab216a2b083392024-03-10T05:12:34ZengElsevieriScience2589-00422024-04-01274109351Exercise training affects calcium ion transport by downregulating the CACNA2D1 protein to reduce hypertension-induced myocardial injury in miceShan Gao0Wei Yao1Rui Zhou2Zuowei Pei3Department of Central Laboratory, Central Hospital of Dalian University of Technology, Dalian, ChinaDepartment of Internal Medicine, The Affiliated Zhong Shan Hospital of Dalian University, Dalian, ChinaDepartment of Internal Medicine, The Affiliated Zhong Shan Hospital of Dalian University, Dalian, ChinaDepartment of Central Laboratory, Central Hospital of Dalian University of Technology, Dalian, China; Department of Cardiology, Central Hospital of Dalian University of Technology, Dalian, China; Faculty of Medicine, Dalian University of Technology, Dalian, China; Corresponding authorSummary: Hypertension is a risk factor for cardiovascular disease, and exercise has cardioprotective effects on the heart. However, the mechanism by which exercise affects hypertension-induced myocardial injury remains unclear. Exercise response model of hypertension-induced myocardial injury in mice was analyzed using multiomics data to identify potential factors. The study found that serum Ca2+ and brain natriuretic peptide concentrations were significantly higher in the HTN (hypertension) group than in the control, HTN+MICT (moderate intensity continuous exercise), and HTN+HIIT (high intensity intermittent exercise) groups. Cardiac tissue damage and fibrosis increased in the HTN group, but exercise training reduced pathological changes, with more improvement in the HTN+HIIT group. Transcriptomic and proteomic studies showed significant differences in CACNA2D1 expression between the different treatment groups. HIIT ameliorated HTN-induced myocardial injury in mice by decreasing Ca2+ concentration and diastolizing vascular smooth muscle by downregulating CACNA2D1 via exercise.http://www.sciencedirect.com/science/article/pii/S2589004224005728Cardiovascular medicineKinesiologyProteomics |
| spellingShingle | Shan Gao Wei Yao Rui Zhou Zuowei Pei Exercise training affects calcium ion transport by downregulating the CACNA2D1 protein to reduce hypertension-induced myocardial injury in mice iScience Cardiovascular medicine Kinesiology Proteomics |
| title | Exercise training affects calcium ion transport by downregulating the CACNA2D1 protein to reduce hypertension-induced myocardial injury in mice |
| title_full | Exercise training affects calcium ion transport by downregulating the CACNA2D1 protein to reduce hypertension-induced myocardial injury in mice |
| title_fullStr | Exercise training affects calcium ion transport by downregulating the CACNA2D1 protein to reduce hypertension-induced myocardial injury in mice |
| title_full_unstemmed | Exercise training affects calcium ion transport by downregulating the CACNA2D1 protein to reduce hypertension-induced myocardial injury in mice |
| title_short | Exercise training affects calcium ion transport by downregulating the CACNA2D1 protein to reduce hypertension-induced myocardial injury in mice |
| title_sort | exercise training affects calcium ion transport by downregulating the cacna2d1 protein to reduce hypertension induced myocardial injury in mice |
| topic | Cardiovascular medicine Kinesiology Proteomics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224005728 |
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