Discovery of Selective Butyrylcholinesterase (BChE) Inhibitors through a Combination of Computational Studies and Biological Evaluations

Discovery of Selective Butyrylcholinesterase (BChE) Inhibitors through a Combination of Computational Studies and Biological Evaluations

As there are increased levels and activity of butyrylcholiesterase (BChE) in the late stage of Alzheimer’s disease (AD), development of selective BChE inhibitors is of vital importance. In this study, a workflow combining computational technologies and biological assays were implemented to...

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Bibliographic Details
Main Authors: You Zhou, Xin Lu, Hongyu Yang, Yao Chen, Feng Wang, Jifu Li, Zhiran Tang, Xifei Cheng, Yingbin Yang, Li Xu, Qingyou Xia
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Molecules
Subjects:
alzheimer’s disease
selective butyrylcholiesterase inhibitors
virtual screening
pharmacophore model
acetylcholinesterase
in vitro enzyme assays
Online Access:https://www.mdpi.com/1420-3049/24/23/4217

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