Efficacy and Safety of Electrohydraulic Lithotripsy Using Peroral Cholangioscopy under Endoscopic Retrograde Cholangiopancreatography Guidance in Older Adults: A Single-Center Retrospective Study
<i>Background and objectives:</i> The safety of electrohydraulic lithotripsy (EHL) in older adults remains unclear. We aimed to investigate the efficacy and safety of EHL using peroral cholangioscopy (POCS) under endoscopic retrograde cholangiopancreatography (ERCP) guidance in older adu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/4/795 |
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| author | Koji Takahashi Hiroshi Ohyama Yuichi Takiguchi Yu Sekine Shodai Toyama Nana Yamada Chihei Sugihara Motoyasu Kan Mayu Ouchi Hiroki Nagashima Yotaro Iino Yuko Kusakabe Kohichiroh Okitsu Izumi Ohno Naoya Kato |
| author_facet | Koji Takahashi Hiroshi Ohyama Yuichi Takiguchi Yu Sekine Shodai Toyama Nana Yamada Chihei Sugihara Motoyasu Kan Mayu Ouchi Hiroki Nagashima Yotaro Iino Yuko Kusakabe Kohichiroh Okitsu Izumi Ohno Naoya Kato |
| author_sort | Koji Takahashi |
| collection | DOAJ |
| description | <i>Background and objectives:</i> The safety of electrohydraulic lithotripsy (EHL) in older adults remains unclear. We aimed to investigate the efficacy and safety of EHL using peroral cholangioscopy (POCS) under endoscopic retrograde cholangiopancreatography (ERCP) guidance in older adults aged ≥80 years. <i>Materials and Methods:</i> This retrospective clinical study was conducted at a single center. Fifty patients with common bile duct stones who underwent EHL using POCS under ERCP guidance at our institution, between April 2017 and September 2022, were enrolled in this study. The eligible patients were divided into an elderly group (<i>n</i> = 21, age ≥80 years) and a non-elderly group (<i>n</i> = 29, age ≤79 years), and were analyzed. <i>Results:</i> A total of 33 and 40 EHL procedures were performed in the elderly and non-elderly groups, respectively. After excluding cases in which stone removal was performed at other institutions, complete removal of common bile duct stones was confirmed in 93.8% and 100% of the elderly and non-elderly groups, respectively (<i>p </i>= 0.20). The mean number of ERCPs required for complete removal of bile duct stones was 2.9 and 4.3 in the elderly and non-elderly groups, respectively (<i>p </i>= 0.17). In the EHL session, the overall occurrence of adverse events was eight and seven in the elderly (24.2%) and non-elderly (17.5%) groups, respectively; however, the difference was insignificant (<i>p </i>= 0.48). <i>Conclusions:</i> EHL using POCS under ERCP guidance is effective in patients aged ≥80 years and there was no significant increase in adverse event rates compared to those aged ≤79 years. |
| first_indexed | 2024-03-11T04:46:01Z |
| format | Article |
| id | doaj.art-d133a9e9075f461cb4413e7b79aeb47a |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T04:46:01Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-d133a9e9075f461cb4413e7b79aeb47a2023-11-17T20:22:11ZengMDPI AGMedicina1010-660X1648-91442023-04-0159479510.3390/medicina59040795Efficacy and Safety of Electrohydraulic Lithotripsy Using Peroral Cholangioscopy under Endoscopic Retrograde Cholangiopancreatography Guidance in Older Adults: A Single-Center Retrospective StudyKoji Takahashi0Hiroshi Ohyama1Yuichi Takiguchi2Yu Sekine3Shodai Toyama4Nana Yamada5Chihei Sugihara6Motoyasu Kan7Mayu Ouchi8Hiroki Nagashima9Yotaro Iino10Yuko Kusakabe11Kohichiroh Okitsu12Izumi Ohno13Naoya Kato14Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Medical Oncology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan<i>Background and objectives:</i> The safety of electrohydraulic lithotripsy (EHL) in older adults remains unclear. We aimed to investigate the efficacy and safety of EHL using peroral cholangioscopy (POCS) under endoscopic retrograde cholangiopancreatography (ERCP) guidance in older adults aged ≥80 years. <i>Materials and Methods:</i> This retrospective clinical study was conducted at a single center. Fifty patients with common bile duct stones who underwent EHL using POCS under ERCP guidance at our institution, between April 2017 and September 2022, were enrolled in this study. The eligible patients were divided into an elderly group (<i>n</i> = 21, age ≥80 years) and a non-elderly group (<i>n</i> = 29, age ≤79 years), and were analyzed. <i>Results:</i> A total of 33 and 40 EHL procedures were performed in the elderly and non-elderly groups, respectively. After excluding cases in which stone removal was performed at other institutions, complete removal of common bile duct stones was confirmed in 93.8% and 100% of the elderly and non-elderly groups, respectively (<i>p </i>= 0.20). The mean number of ERCPs required for complete removal of bile duct stones was 2.9 and 4.3 in the elderly and non-elderly groups, respectively (<i>p </i>= 0.17). In the EHL session, the overall occurrence of adverse events was eight and seven in the elderly (24.2%) and non-elderly (17.5%) groups, respectively; however, the difference was insignificant (<i>p </i>= 0.48). <i>Conclusions:</i> EHL using POCS under ERCP guidance is effective in patients aged ≥80 years and there was no significant increase in adverse event rates compared to those aged ≤79 years.https://www.mdpi.com/1648-9144/59/4/795common bile duct stoneelderlyelectrohydraulic lithotripsyendoscopic retrograde cholangiopancreatographysafety |
| spellingShingle | Koji Takahashi Hiroshi Ohyama Yuichi Takiguchi Yu Sekine Shodai Toyama Nana Yamada Chihei Sugihara Motoyasu Kan Mayu Ouchi Hiroki Nagashima Yotaro Iino Yuko Kusakabe Kohichiroh Okitsu Izumi Ohno Naoya Kato Efficacy and Safety of Electrohydraulic Lithotripsy Using Peroral Cholangioscopy under Endoscopic Retrograde Cholangiopancreatography Guidance in Older Adults: A Single-Center Retrospective Study Medicina common bile duct stone elderly electrohydraulic lithotripsy endoscopic retrograde cholangiopancreatography safety |
| title | Efficacy and Safety of Electrohydraulic Lithotripsy Using Peroral Cholangioscopy under Endoscopic Retrograde Cholangiopancreatography Guidance in Older Adults: A Single-Center Retrospective Study |
| title_full | Efficacy and Safety of Electrohydraulic Lithotripsy Using Peroral Cholangioscopy under Endoscopic Retrograde Cholangiopancreatography Guidance in Older Adults: A Single-Center Retrospective Study |
| title_fullStr | Efficacy and Safety of Electrohydraulic Lithotripsy Using Peroral Cholangioscopy under Endoscopic Retrograde Cholangiopancreatography Guidance in Older Adults: A Single-Center Retrospective Study |
| title_full_unstemmed | Efficacy and Safety of Electrohydraulic Lithotripsy Using Peroral Cholangioscopy under Endoscopic Retrograde Cholangiopancreatography Guidance in Older Adults: A Single-Center Retrospective Study |
| title_short | Efficacy and Safety of Electrohydraulic Lithotripsy Using Peroral Cholangioscopy under Endoscopic Retrograde Cholangiopancreatography Guidance in Older Adults: A Single-Center Retrospective Study |
| title_sort | efficacy and safety of electrohydraulic lithotripsy using peroral cholangioscopy under endoscopic retrograde cholangiopancreatography guidance in older adults a single center retrospective study |
| topic | common bile duct stone elderly electrohydraulic lithotripsy endoscopic retrograde cholangiopancreatography safety |
| url | https://www.mdpi.com/1648-9144/59/4/795 |
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