Inhibition of HIV-1 release by ADAM metalloproteinase inhibitors

Inhibition of HIV-1 release by ADAM metalloproteinase inhibitors

HIV-1 gp120 glycan binding to C-type lectin adhesion receptor L-selectin/CD62L on CD4 T cells facilitates viral attachment and entry. Paradoxically, the adhesion receptor impedes HIV-1 budding from infected T cells and the viral release requires the shedding of CD62L. To systematically investigate C...

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Bibliographic Details
Main Authors: Joanna Ireland, Jason Segura, Genbin Shi, Julianna Buchwald, Gwynne Roth, Thomas Juncheng Shen, Ruipeng Wang, Xinhua Ji, Elizabeth R. Fischer, Susan Moir, Tae-Wook Chun, Peter D. Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Microbiology
Subjects:
HIV-1 infection of CD4 T-cells
viral release
L-selectin (CD62L)
ADAM metallopeptidase domain
ADAM10 and 17
batimastat (BB-94)
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1385775/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2024.1385775/full

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