Body Mass Index Modified Predictive Ability Of Biomarkers For Protein-Energy Wasting In Prevalent Hemodialysis Patients
Protein-energy wasting (PEW) is crucial complication in prevalent hemodialysis (HD) patients. Abnormality of biomarkers such as IL-6, NT-pro-BNP, and adiponectin (ADPN) contribute to PEW. However, associations of the biomarkers with PEW according to BMI levels have not been fully evaluated. Thus tho...
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2012-06-01
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| Series: | Kidney Research and Clinical Practice |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211913212004354 |
| _version_ | 1811300780739657728 |
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| author | Hirokazu Honda Kanji Shishido Tetsuo Michihata Hiroaki Ogata Fumihiko Koiwa Eriko Kinugasa Tadao Akizawa |
| author_facet | Hirokazu Honda Kanji Shishido Tetsuo Michihata Hiroaki Ogata Fumihiko Koiwa Eriko Kinugasa Tadao Akizawa |
| author_sort | Hirokazu Honda |
| collection | DOAJ |
| description | Protein-energy wasting (PEW) is crucial complication in prevalent hemodialysis (HD) patients. Abnormality of biomarkers such as IL-6, NT-pro-BNP, and adiponectin (ADPN) contribute to PEW. However, associations of the biomarkers with PEW according to BMI levels have not been fully evaluated. Thus those associations were assessed by a cross-sectional cohort study of prevalent HD patients (n=386). PEW was defined by subjective global assessment (n=108). IL-6 levels were inversely, and NT-pro-BNP and ADPN levels were positively correlated with BMI levels. Odds ratio (OR) of log IL-6 (OR 1.5, CI 1.0, 2.2), log NT-pro-BNP (OR 1.7, CI 1.3, 2.2), and log ADPN (OR 1.9, CI 1.1, 3.2) to PEW were significantly increased in logistic multivariate regression model. ORs of log NT-pro-BNP and log ADPN for PEW were progressively increased in patients with threshold 21 kg/m2<BMI, but progressively decreased in those below this threshold. On the other hand, OR of log IL-6 for PEW was progressively decreased in patients with threshold 21 kg/m2<BMI, but similar in those below this threshold. These associations were confirmed by the models adjusted with confounder. In conclusions, predictive values of IL-6, NT-pro-BNP and ADPN for PEW state may be dependent on BMI levels in prevalent HD patients.fx1 |
| first_indexed | 2024-04-13T06:57:22Z |
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| id | doaj.art-d1352f5fcf1b4f45b46a61ccb0965ea7 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 |
| language | English |
| last_indexed | 2024-04-13T06:57:22Z |
| publishDate | 2012-06-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-d1352f5fcf1b4f45b46a61ccb0965ea72022-12-22T02:57:13ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322012-06-01312A3610.1016/j.krcp.2012.04.402Body Mass Index Modified Predictive Ability Of Biomarkers For Protein-Energy Wasting In Prevalent Hemodialysis PatientsHirokazu Honda0Kanji Shishido1Tetsuo Michihata2Hiroaki Ogata3Fumihiko Koiwa4Eriko Kinugasa5Tadao Akizawa6Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, JapanKawasaki Clinic, Kawasaki, JapanEbara Clinic, Tokyo, JapanDepartments of舲 Internal Medicine, Showa University Northern Yokohama Hospital, Yokohama, JapanDivision of Nephrology, Department of Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.Departments of舲 Internal Medicine, Showa University Northern Yokohama Hospital, Yokohama, JapanDivision of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, JapanProtein-energy wasting (PEW) is crucial complication in prevalent hemodialysis (HD) patients. Abnormality of biomarkers such as IL-6, NT-pro-BNP, and adiponectin (ADPN) contribute to PEW. However, associations of the biomarkers with PEW according to BMI levels have not been fully evaluated. Thus those associations were assessed by a cross-sectional cohort study of prevalent HD patients (n=386). PEW was defined by subjective global assessment (n=108). IL-6 levels were inversely, and NT-pro-BNP and ADPN levels were positively correlated with BMI levels. Odds ratio (OR) of log IL-6 (OR 1.5, CI 1.0, 2.2), log NT-pro-BNP (OR 1.7, CI 1.3, 2.2), and log ADPN (OR 1.9, CI 1.1, 3.2) to PEW were significantly increased in logistic multivariate regression model. ORs of log NT-pro-BNP and log ADPN for PEW were progressively increased in patients with threshold 21 kg/m2<BMI, but progressively decreased in those below this threshold. On the other hand, OR of log IL-6 for PEW was progressively decreased in patients with threshold 21 kg/m2<BMI, but similar in those below this threshold. These associations were confirmed by the models adjusted with confounder. In conclusions, predictive values of IL-6, NT-pro-BNP and ADPN for PEW state may be dependent on BMI levels in prevalent HD patients.fx1http://www.sciencedirect.com/science/article/pii/S2211913212004354 |
| spellingShingle | Hirokazu Honda Kanji Shishido Tetsuo Michihata Hiroaki Ogata Fumihiko Koiwa Eriko Kinugasa Tadao Akizawa Body Mass Index Modified Predictive Ability Of Biomarkers For Protein-Energy Wasting In Prevalent Hemodialysis Patients Kidney Research and Clinical Practice |
| title | Body Mass Index Modified Predictive Ability Of Biomarkers For Protein-Energy Wasting In Prevalent Hemodialysis Patients |
| title_full | Body Mass Index Modified Predictive Ability Of Biomarkers For Protein-Energy Wasting In Prevalent Hemodialysis Patients |
| title_fullStr | Body Mass Index Modified Predictive Ability Of Biomarkers For Protein-Energy Wasting In Prevalent Hemodialysis Patients |
| title_full_unstemmed | Body Mass Index Modified Predictive Ability Of Biomarkers For Protein-Energy Wasting In Prevalent Hemodialysis Patients |
| title_short | Body Mass Index Modified Predictive Ability Of Biomarkers For Protein-Energy Wasting In Prevalent Hemodialysis Patients |
| title_sort | body mass index modified predictive ability of biomarkers for protein energy wasting in prevalent hemodialysis patients |
| url | http://www.sciencedirect.com/science/article/pii/S2211913212004354 |
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