Sub-segmental pulmonary thromboembolism in a pregnant woman with generalized lupus erythematosus, triple-negative antiphospholipid syndrome, and protein C deficiency. A case report
Autoimmune diseases and thrombophilic disorders, notably antiphospholipid syndrome (APS) and protein S deficiency, present a formidable challenge in pregnancy, substantially increasing the risk of thromboembolic complications by up to 20%. Pulmonary thromboembolism (PTE), characterized by a signific...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043324001560 |
| _version_ | 1797257710707671040 |
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| author | Arlin Montoya Rodríguez, MD Mario Mayorga Duarte, MD Sayonara Sandino López, MD Víctor Rosales Obregón, MD Mario Enmanuel López Marenco, MD |
| author_facet | Arlin Montoya Rodríguez, MD Mario Mayorga Duarte, MD Sayonara Sandino López, MD Víctor Rosales Obregón, MD Mario Enmanuel López Marenco, MD |
| author_sort | Arlin Montoya Rodríguez, MD |
| collection | DOAJ |
| description | Autoimmune diseases and thrombophilic disorders, notably antiphospholipid syndrome (APS) and protein S deficiency, present a formidable challenge in pregnancy, substantially increasing the risk of thromboembolic complications by up to 20%. Pulmonary thromboembolism (PTE), characterized by a significantly higher maternal mortality rate, is of particular concern.APS, defined by the presence of antiphospholipid antibodies, emerges as a pivotal risk factor for PTE during pregnancy, especially in women exhibiting triple negativity. Concurrently, protein S deficiency further amplifies vulnerability to thromboembolic events, establishing a high-risk scenario for pregnant individuals.In a case involving a 29-year-old pregnant woman with a history of generalized lupus erythematosus, triple-negative antiphospholipid syndrome, and protein S deficiency, sudden-onset dyspnea prompted thorough investigation. Despite her complex medical history, a multidisciplinary approach led to the accurate diagnosis and successful management of subsegmental pulmonary thromboembolism, ensuring the well-being of both mother and fetus.Effectively managing PTE during pregnancy demands a comprehensive, multidisciplinary approach involving collaboration among obstetricians, internists, rheumatologists, and hematologists. Accurate diagnosis, tailored anticoagulation strategies, and continuous monitoring stand as indispensable pillars for maternal and fetal well-being. |
| first_indexed | 2024-04-24T22:41:58Z |
| format | Article |
| id | doaj.art-d1357972d33d4b33875b4144736b4a69 |
| institution | Directory Open Access Journal |
| issn | 1930-0433 |
| language | English |
| last_indexed | 2024-04-24T22:41:58Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj.art-d1357972d33d4b33875b4144736b4a692024-03-19T04:18:22ZengElsevierRadiology Case Reports1930-04332024-06-0119622492252Sub-segmental pulmonary thromboembolism in a pregnant woman with generalized lupus erythematosus, triple-negative antiphospholipid syndrome, and protein C deficiency. A case reportArlin Montoya Rodríguez, MD0Mario Mayorga Duarte, MD1Sayonara Sandino López, MD2Víctor Rosales Obregón, MD3Mario Enmanuel López Marenco, MD4Department of Obstetric Critical Care and Internal Medicine, Bertha Calderón Roque Hospital, Managua, Nicaragua; Corresponding author.Department of Internal Medicine, Hilario Sánchez Vázquez Hospital, Masaya, NicaraguaDepartment of Rheumatology, Manolo Morales Peralta Hospital, Managua, NicaraguaDepartment of Nuclear Medicine, Nora Astorga National Radiotherapy Hospital, Managua, NicaraguaDepartment of Obstetric Critical Care and Internal Medicine, Bertha Calderón Roque Hospital, Managua, NicaraguaAutoimmune diseases and thrombophilic disorders, notably antiphospholipid syndrome (APS) and protein S deficiency, present a formidable challenge in pregnancy, substantially increasing the risk of thromboembolic complications by up to 20%. Pulmonary thromboembolism (PTE), characterized by a significantly higher maternal mortality rate, is of particular concern.APS, defined by the presence of antiphospholipid antibodies, emerges as a pivotal risk factor for PTE during pregnancy, especially in women exhibiting triple negativity. Concurrently, protein S deficiency further amplifies vulnerability to thromboembolic events, establishing a high-risk scenario for pregnant individuals.In a case involving a 29-year-old pregnant woman with a history of generalized lupus erythematosus, triple-negative antiphospholipid syndrome, and protein S deficiency, sudden-onset dyspnea prompted thorough investigation. Despite her complex medical history, a multidisciplinary approach led to the accurate diagnosis and successful management of subsegmental pulmonary thromboembolism, ensuring the well-being of both mother and fetus.Effectively managing PTE during pregnancy demands a comprehensive, multidisciplinary approach involving collaboration among obstetricians, internists, rheumatologists, and hematologists. Accurate diagnosis, tailored anticoagulation strategies, and continuous monitoring stand as indispensable pillars for maternal and fetal well-being.http://www.sciencedirect.com/science/article/pii/S1930043324001560Thrombophilic disordersAntiphospholipid síndromeProtein S deficiencyPregnancy complicationsPulmonary thromboembolism (PTE) |
| spellingShingle | Arlin Montoya Rodríguez, MD Mario Mayorga Duarte, MD Sayonara Sandino López, MD Víctor Rosales Obregón, MD Mario Enmanuel López Marenco, MD Sub-segmental pulmonary thromboembolism in a pregnant woman with generalized lupus erythematosus, triple-negative antiphospholipid syndrome, and protein C deficiency. A case report Radiology Case Reports Thrombophilic disorders Antiphospholipid síndrome Protein S deficiency Pregnancy complications Pulmonary thromboembolism (PTE) |
| title | Sub-segmental pulmonary thromboembolism in a pregnant woman with generalized lupus erythematosus, triple-negative antiphospholipid syndrome, and protein C deficiency. A case report |
| title_full | Sub-segmental pulmonary thromboembolism in a pregnant woman with generalized lupus erythematosus, triple-negative antiphospholipid syndrome, and protein C deficiency. A case report |
| title_fullStr | Sub-segmental pulmonary thromboembolism in a pregnant woman with generalized lupus erythematosus, triple-negative antiphospholipid syndrome, and protein C deficiency. A case report |
| title_full_unstemmed | Sub-segmental pulmonary thromboembolism in a pregnant woman with generalized lupus erythematosus, triple-negative antiphospholipid syndrome, and protein C deficiency. A case report |
| title_short | Sub-segmental pulmonary thromboembolism in a pregnant woman with generalized lupus erythematosus, triple-negative antiphospholipid syndrome, and protein C deficiency. A case report |
| title_sort | sub segmental pulmonary thromboembolism in a pregnant woman with generalized lupus erythematosus triple negative antiphospholipid syndrome and protein c deficiency a case report |
| topic | Thrombophilic disorders Antiphospholipid síndrome Protein S deficiency Pregnancy complications Pulmonary thromboembolism (PTE) |
| url | http://www.sciencedirect.com/science/article/pii/S1930043324001560 |
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