Natural desiccated thyroid for the treatment of hypothyroidism?
Primary hypothyroidism affects about 3% of the general population in Europe. Early treatments in the late 19th Century involved subcutaneous as well as oral administration of thyroid extract. Until the early 1970s, the majority of people across the world with hypothyroidism were treated with natural...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1309159/full |
| _version_ | 1797362353107369984 |
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| author | Adrian H. Heald Adrian H. Heald Peter Taylor Lakdasa Premawardhana Mike Stedman Colin Dayan |
| author_facet | Adrian H. Heald Adrian H. Heald Peter Taylor Lakdasa Premawardhana Mike Stedman Colin Dayan |
| author_sort | Adrian H. Heald |
| collection | DOAJ |
| description | Primary hypothyroidism affects about 3% of the general population in Europe. Early treatments in the late 19th Century involved subcutaneous as well as oral administration of thyroid extract. Until the early 1970s, the majority of people across the world with hypothyroidism were treated with natural desiccated thyroid (NDT) (derived from pig thyroid glands) in various formulations, with the majority of people since then being treated with levothyroxine (L-thyroxine). There is emerging evidence that may account for the efficacy of liothyronine (NDT contains a mixture of levothyroxine and liothyronine) in people who are symptomatically unresponsive to levothyroxine. While this is a highly selected group of people, the severity and chronicity of their symptoms and the fact that many patients have found their symptoms to be alleviated, can be viewed as valid evidence for the potential benefit of NDT when given after careful consideration of other differential diagnoses and other treatment options. |
| first_indexed | 2024-03-08T16:05:53Z |
| format | Article |
| id | doaj.art-d13778d5fe864103bf8e992fe9d5e00c |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T16:05:53Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-d13778d5fe864103bf8e992fe9d5e00c2024-01-08T06:11:06ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-01-011410.3389/fendo.2023.13091591309159Natural desiccated thyroid for the treatment of hypothyroidism?Adrian H. Heald0Adrian H. Heald1Peter Taylor2Lakdasa Premawardhana3Mike Stedman4Colin Dayan5The School of Medicine and Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United KingdomDepartment of Endocrinology and Diabetes, Salford Royal Hospital, Salford, United KingdomThyroid Research Group, Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United KingdomThyroid Research Group, Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United KingdomRes Consortium, Andover, United KingdomThyroid Research Group, Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United KingdomPrimary hypothyroidism affects about 3% of the general population in Europe. Early treatments in the late 19th Century involved subcutaneous as well as oral administration of thyroid extract. Until the early 1970s, the majority of people across the world with hypothyroidism were treated with natural desiccated thyroid (NDT) (derived from pig thyroid glands) in various formulations, with the majority of people since then being treated with levothyroxine (L-thyroxine). There is emerging evidence that may account for the efficacy of liothyronine (NDT contains a mixture of levothyroxine and liothyronine) in people who are symptomatically unresponsive to levothyroxine. While this is a highly selected group of people, the severity and chronicity of their symptoms and the fact that many patients have found their symptoms to be alleviated, can be viewed as valid evidence for the potential benefit of NDT when given after careful consideration of other differential diagnoses and other treatment options.https://www.frontiersin.org/articles/10.3389/fendo.2023.1309159/fullhypothyroidismtreatment unresponsiveNDTliothyroninecost |
| spellingShingle | Adrian H. Heald Adrian H. Heald Peter Taylor Lakdasa Premawardhana Mike Stedman Colin Dayan Natural desiccated thyroid for the treatment of hypothyroidism? Frontiers in Endocrinology hypothyroidism treatment unresponsive NDT liothyronine cost |
| title | Natural desiccated thyroid for the treatment of hypothyroidism? |
| title_full | Natural desiccated thyroid for the treatment of hypothyroidism? |
| title_fullStr | Natural desiccated thyroid for the treatment of hypothyroidism? |
| title_full_unstemmed | Natural desiccated thyroid for the treatment of hypothyroidism? |
| title_short | Natural desiccated thyroid for the treatment of hypothyroidism? |
| title_sort | natural desiccated thyroid for the treatment of hypothyroidism |
| topic | hypothyroidism treatment unresponsive NDT liothyronine cost |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1309159/full |
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