Clinical symptoms and their relationship with cognitive impairment in elderly patients with depressive disorder
ObjectiveTo evaluate the correlation between clinical symptoms and cognitive impairment in elderly patients with depressive disorder.MethodsIn this retrospective study, a total of 123 elderly patients with depressive disorder admitted to our hospital from January 2020 to February 2021 were included....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1009653/full |
| _version_ | 1797996800676724736 |
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| author | Zhenguo Wu Zhenguo Wu Guanli Su Guanli Su Wenting Lu Wenting Lu Lin Liu Lin Liu Zixuan Zhou Zixuan Zhou Bingchuan Xie |
| author_facet | Zhenguo Wu Zhenguo Wu Guanli Su Guanli Su Wenting Lu Wenting Lu Lin Liu Lin Liu Zixuan Zhou Zixuan Zhou Bingchuan Xie |
| author_sort | Zhenguo Wu |
| collection | DOAJ |
| description | ObjectiveTo evaluate the correlation between clinical symptoms and cognitive impairment in elderly patients with depressive disorder.MethodsIn this retrospective study, a total of 123 elderly patients with depressive disorder admitted to our hospital from January 2020 to February 2021 were included. Patients' cognitive function was assessed by the Montreal Cognitive Assessment Scale (MoCA). According to the combination of cognitive impairment or not, patients were divided into the combined group (64 cases) and the depressive disorder group (59 cases). In addition, 70 healthy people who came to our hospital for physical examination during the same period were randomly selected as the healthy group.ResultsThe incidence of severe cognitive impairment in the combined group (33, 51.56%) was significantly higher than that in the depression group (19, 32.20%), the difference was statistically significant (P = 0.003). The incidence of somatization symptoms, suicidal tendency, retardation of thinking, diminution of energy, anxiety and sleep disorder in the combined group were higher than that in the depressive disorder group with significant difference [30 (56.88%) vs. 16 (27.12%), P = 0.024; 12 (18.75%) vs. 3 (5.08%), P = 0.021; 33 (51.56%) vs. 14 (23.73%), P = 0.002; 37 (57.81%) vs. 23 (38.98%), P = 0.029; 42 (65.63) vs. 25 (42.37), P = 0.011; 50 (78.13) vs. 42 (71.19), P = 0.031, respectively]. Spearman rank correlation analysis suggested that somatic symptom, mood change, suicidal tendency, retardation of thinking, diminution of energy, anxiety, and sleep disorder were negatively correlated with cognitive impairment, respectively (r =-0.161, −0.672, −0.262, −0.871, −0.421, −0.571, −0.512, P < 0.001).ConclusionThe clinical symptoms of depressive disorder were negatively correlated with cognitive impairment. Somatic symptoms, suicidal tendency, retardation of thinking, diminution of energy, anxiety, and sleep disorder were the risk factors for cognitive impairment. |
| first_indexed | 2024-04-11T10:23:05Z |
| format | Article |
| id | doaj.art-d13bbf2d4db347dba496652b756b2dcf |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-11T10:23:05Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-d13bbf2d4db347dba496652b756b2dcf2022-12-22T04:29:41ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-10-011310.3389/fpsyt.2022.10096531009653Clinical symptoms and their relationship with cognitive impairment in elderly patients with depressive disorderZhenguo Wu0Zhenguo Wu1Guanli Su2Guanli Su3Wenting Lu4Wenting Lu5Lin Liu6Lin Liu7Zixuan Zhou8Zixuan Zhou9Bingchuan Xie10Department of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang, ChinaMental Health Institute of the Hebei Medical University, Shijiazhuang, ChinaDepartment of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang, ChinaMental Health Institute of the Hebei Medical University, Shijiazhuang, ChinaDepartment of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang, ChinaMental Health Institute of the Hebei Medical University, Shijiazhuang, ChinaDepartment of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang, ChinaMental Health Institute of the Hebei Medical University, Shijiazhuang, ChinaDepartment of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang, ChinaMental Health Institute of the Hebei Medical University, Shijiazhuang, ChinaDepartment of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, ChinaObjectiveTo evaluate the correlation between clinical symptoms and cognitive impairment in elderly patients with depressive disorder.MethodsIn this retrospective study, a total of 123 elderly patients with depressive disorder admitted to our hospital from January 2020 to February 2021 were included. Patients' cognitive function was assessed by the Montreal Cognitive Assessment Scale (MoCA). According to the combination of cognitive impairment or not, patients were divided into the combined group (64 cases) and the depressive disorder group (59 cases). In addition, 70 healthy people who came to our hospital for physical examination during the same period were randomly selected as the healthy group.ResultsThe incidence of severe cognitive impairment in the combined group (33, 51.56%) was significantly higher than that in the depression group (19, 32.20%), the difference was statistically significant (P = 0.003). The incidence of somatization symptoms, suicidal tendency, retardation of thinking, diminution of energy, anxiety and sleep disorder in the combined group were higher than that in the depressive disorder group with significant difference [30 (56.88%) vs. 16 (27.12%), P = 0.024; 12 (18.75%) vs. 3 (5.08%), P = 0.021; 33 (51.56%) vs. 14 (23.73%), P = 0.002; 37 (57.81%) vs. 23 (38.98%), P = 0.029; 42 (65.63) vs. 25 (42.37), P = 0.011; 50 (78.13) vs. 42 (71.19), P = 0.031, respectively]. Spearman rank correlation analysis suggested that somatic symptom, mood change, suicidal tendency, retardation of thinking, diminution of energy, anxiety, and sleep disorder were negatively correlated with cognitive impairment, respectively (r =-0.161, −0.672, −0.262, −0.871, −0.421, −0.571, −0.512, P < 0.001).ConclusionThe clinical symptoms of depressive disorder were negatively correlated with cognitive impairment. Somatic symptoms, suicidal tendency, retardation of thinking, diminution of energy, anxiety, and sleep disorder were the risk factors for cognitive impairment.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1009653/fullgeriatric depression disordercognitive impairmentcorrelation analysisrisk factorscognitive |
| spellingShingle | Zhenguo Wu Zhenguo Wu Guanli Su Guanli Su Wenting Lu Wenting Lu Lin Liu Lin Liu Zixuan Zhou Zixuan Zhou Bingchuan Xie Clinical symptoms and their relationship with cognitive impairment in elderly patients with depressive disorder Frontiers in Psychiatry geriatric depression disorder cognitive impairment correlation analysis risk factors cognitive |
| title | Clinical symptoms and their relationship with cognitive impairment in elderly patients with depressive disorder |
| title_full | Clinical symptoms and their relationship with cognitive impairment in elderly patients with depressive disorder |
| title_fullStr | Clinical symptoms and their relationship with cognitive impairment in elderly patients with depressive disorder |
| title_full_unstemmed | Clinical symptoms and their relationship with cognitive impairment in elderly patients with depressive disorder |
| title_short | Clinical symptoms and their relationship with cognitive impairment in elderly patients with depressive disorder |
| title_sort | clinical symptoms and their relationship with cognitive impairment in elderly patients with depressive disorder |
| topic | geriatric depression disorder cognitive impairment correlation analysis risk factors cognitive |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1009653/full |
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