Is the mitochondrion a promising drug target in trypanosomatids?

Is the mitochondrion a promising drug target in trypanosomatids?

The trypanosomatids Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are etiological agents of important neglected tropical diseases, affecting millions of people worldwide, and the drugs available for these diseases present several limitations. Novel efficient and nontoxic drugs are necess...

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Bibliographic Details
Main Authors:	Yasmin Pedra-Rezende, Ana Cristina Souza Bombaça, Rubem Figueiredo Sadok Menna-Barreto/
Format:	Article
Language:	English
Published:	Fundação Oswaldo Cruz (FIOCRUZ) 2022-02-01
Series:	Memorias do Instituto Oswaldo Cruz
Subjects:	trypanosomatids mitochondrion oxidative stress chemotherapy mitochondrial protein import bioenergetics
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762022000100850&tlng=en

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