Gene Regulation of Biofilm-Associated Functional Amyloids
Biofilms are bacterial communities encased in a rigid yet dynamic extracellular matrix. The sociobiology of bacterial communities within a biofilm is astonishing, with environmental factors playing a crucial role in determining the switch from planktonic to a sessile form of life. The mechanism of b...
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MDPI AG
2021-04-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/4/490 |
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| author | Khushal Khambhati Jaykumar Patel Vijaylaxmi Saxena Parvathy A Neha Jain |
| author_facet | Khushal Khambhati Jaykumar Patel Vijaylaxmi Saxena Parvathy A Neha Jain |
| author_sort | Khushal Khambhati |
| collection | DOAJ |
| description | Biofilms are bacterial communities encased in a rigid yet dynamic extracellular matrix. The sociobiology of bacterial communities within a biofilm is astonishing, with environmental factors playing a crucial role in determining the switch from planktonic to a sessile form of life. The mechanism of biofilm biogenesis is an intriguingly complex phenomenon governed by the tight regulation of expression of various biofilm-matrix components. One of the major constituents of the biofilm matrix is proteinaceous polymers called amyloids. Since the discovery, the significance of biofilm-associated amyloids in adhesion, aggregation, protection, and infection development has been much appreciated. The amyloid expression and assembly is regulated spatio-temporarily within the bacterial cells to perform a diverse function. This review provides a comprehensive account of the genetic regulation associated with the expression of amyloids in bacteria. The stringent control ensures optimal utilization of amyloid scaffold during biofilm biogenesis. We conclude the review by summarizing environmental factors influencing the expression and regulation of amyloids. |
| first_indexed | 2024-03-10T12:12:56Z |
| format | Article |
| id | doaj.art-d13d728f8db04ed0b7d4208b87be0bcc |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T12:12:56Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
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| series | Pathogens |
| spelling | doaj.art-d13d728f8db04ed0b7d4208b87be0bcc2023-11-21T16:07:39ZengMDPI AGPathogens2076-08172021-04-0110449010.3390/pathogens10040490Gene Regulation of Biofilm-Associated Functional AmyloidsKhushal Khambhati0Jaykumar Patel1Vijaylaxmi Saxena2Parvathy A3Neha Jain4Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur NH 65, Nagaur Road, Karwar, Rajasthan 342037, IndiaDepartment of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur NH 65, Nagaur Road, Karwar, Rajasthan 342037, IndiaDepartment of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur NH 65, Nagaur Road, Karwar, Rajasthan 342037, IndiaDepartment of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur NH 65, Nagaur Road, Karwar, Rajasthan 342037, IndiaDepartment of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur NH 65, Nagaur Road, Karwar, Rajasthan 342037, IndiaBiofilms are bacterial communities encased in a rigid yet dynamic extracellular matrix. The sociobiology of bacterial communities within a biofilm is astonishing, with environmental factors playing a crucial role in determining the switch from planktonic to a sessile form of life. The mechanism of biofilm biogenesis is an intriguingly complex phenomenon governed by the tight regulation of expression of various biofilm-matrix components. One of the major constituents of the biofilm matrix is proteinaceous polymers called amyloids. Since the discovery, the significance of biofilm-associated amyloids in adhesion, aggregation, protection, and infection development has been much appreciated. The amyloid expression and assembly is regulated spatio-temporarily within the bacterial cells to perform a diverse function. This review provides a comprehensive account of the genetic regulation associated with the expression of amyloids in bacteria. The stringent control ensures optimal utilization of amyloid scaffold during biofilm biogenesis. We conclude the review by summarizing environmental factors influencing the expression and regulation of amyloids.https://www.mdpi.com/2076-0817/10/4/490biofilmsfunctional amyloidsgene regulationextracellular matrixCsgATasA |
| spellingShingle | Khushal Khambhati Jaykumar Patel Vijaylaxmi Saxena Parvathy A Neha Jain Gene Regulation of Biofilm-Associated Functional Amyloids Pathogens biofilms functional amyloids gene regulation extracellular matrix CsgA TasA |
| title | Gene Regulation of Biofilm-Associated Functional Amyloids |
| title_full | Gene Regulation of Biofilm-Associated Functional Amyloids |
| title_fullStr | Gene Regulation of Biofilm-Associated Functional Amyloids |
| title_full_unstemmed | Gene Regulation of Biofilm-Associated Functional Amyloids |
| title_short | Gene Regulation of Biofilm-Associated Functional Amyloids |
| title_sort | gene regulation of biofilm associated functional amyloids |
| topic | biofilms functional amyloids gene regulation extracellular matrix CsgA TasA |
| url | https://www.mdpi.com/2076-0817/10/4/490 |
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