Dual Role of the PTPN13 Tyrosine Phosphatase in Cancer
In this review article, we present the current knowledge on PTPN13, a class I non-receptor protein tyrosine phosphatase identified in 1994. We focus particularly on its role in cancer, where PTPN13 acts as an oncogenic protein and also a tumor suppressor. To try to understand these apparent contradi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/10/12/1659 |
| _version_ | 1827700289263632384 |
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| author | Soha Mcheik Leticia Aptecar Peter Coopman Véronique D’Hondt Gilles Freiss |
| author_facet | Soha Mcheik Leticia Aptecar Peter Coopman Véronique D’Hondt Gilles Freiss |
| author_sort | Soha Mcheik |
| collection | DOAJ |
| description | In this review article, we present the current knowledge on PTPN13, a class I non-receptor protein tyrosine phosphatase identified in 1994. We focus particularly on its role in cancer, where PTPN13 acts as an oncogenic protein and also a tumor suppressor. To try to understand these apparent contradictory functions, we discuss PTPN13 implication in the FAS and oncogenic tyrosine kinase signaling pathways and in the associated biological activities, as well as its post-transcriptional and epigenetic regulation. Then, we describe PTPN13 clinical significance as a prognostic marker in different cancer types and its impact on anti-cancer treatment sensitivity. Finally, we present future research axes following recent findings on its role in cell junction regulation that implicate PTPN13 in cell death and cell migration, two major hallmarks of tumor formation and progression. |
| first_indexed | 2024-03-10T14:09:12Z |
| format | Article |
| id | doaj.art-d13d7fa957264b17aa33b52758eab247 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T14:09:12Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-d13d7fa957264b17aa33b52758eab2472023-11-21T00:26:29ZengMDPI AGBiomolecules2218-273X2020-12-011012165910.3390/biom10121659Dual Role of the PTPN13 Tyrosine Phosphatase in CancerSoha Mcheik0Leticia Aptecar1Peter Coopman2Véronique D’Hondt3Gilles Freiss4IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, F-34298 Montpellier, FranceIRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, F-34298 Montpellier, FranceIRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, F-34298 Montpellier, FranceIRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, F-34298 Montpellier, FranceIRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, F-34298 Montpellier, FranceIn this review article, we present the current knowledge on PTPN13, a class I non-receptor protein tyrosine phosphatase identified in 1994. We focus particularly on its role in cancer, where PTPN13 acts as an oncogenic protein and also a tumor suppressor. To try to understand these apparent contradictory functions, we discuss PTPN13 implication in the FAS and oncogenic tyrosine kinase signaling pathways and in the associated biological activities, as well as its post-transcriptional and epigenetic regulation. Then, we describe PTPN13 clinical significance as a prognostic marker in different cancer types and its impact on anti-cancer treatment sensitivity. Finally, we present future research axes following recent findings on its role in cell junction regulation that implicate PTPN13 in cell death and cell migration, two major hallmarks of tumor formation and progression.https://www.mdpi.com/2218-273X/10/12/1659PTPN13cell signalingcancertumor suppressoroncogene |
| spellingShingle | Soha Mcheik Leticia Aptecar Peter Coopman Véronique D’Hondt Gilles Freiss Dual Role of the PTPN13 Tyrosine Phosphatase in Cancer Biomolecules PTPN13 cell signaling cancer tumor suppressor oncogene |
| title | Dual Role of the PTPN13 Tyrosine Phosphatase in Cancer |
| title_full | Dual Role of the PTPN13 Tyrosine Phosphatase in Cancer |
| title_fullStr | Dual Role of the PTPN13 Tyrosine Phosphatase in Cancer |
| title_full_unstemmed | Dual Role of the PTPN13 Tyrosine Phosphatase in Cancer |
| title_short | Dual Role of the PTPN13 Tyrosine Phosphatase in Cancer |
| title_sort | dual role of the ptpn13 tyrosine phosphatase in cancer |
| topic | PTPN13 cell signaling cancer tumor suppressor oncogene |
| url | https://www.mdpi.com/2218-273X/10/12/1659 |
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