<i>Zingiber officinale</i> Roscoe Rhizomes Attenuate Oxaliplatin-Induced Neuropathic Pain in Mice
Oxaliplatin is a platinum derivative chemotherapeutic drug widely used against cancers, but even a single treatment can induce a severe allodynia that requires treatment interruption and dose diminution. The rhizome of <i>Zingiber officinale</i> roscoe (<i>Z. officinale</i>,...
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MDPI AG
2021-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/3/548 |
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| author | Ji Hwan Lee Daeun Min Donghun Lee Woojin Kim |
| author_facet | Ji Hwan Lee Daeun Min Donghun Lee Woojin Kim |
| author_sort | Ji Hwan Lee |
| collection | DOAJ |
| description | Oxaliplatin is a platinum derivative chemotherapeutic drug widely used against cancers, but even a single treatment can induce a severe allodynia that requires treatment interruption and dose diminution. The rhizome of <i>Zingiber officinale</i> roscoe (<i>Z. officinale</i>, ginger), has been widely used in traditional medicine to treat various diseases causing pain; however, its effect against oxaliplatin-induced neuropathic pain has never been assessed. In mice, a single oxaliplatin (6 mg/kg, i.p.) treatment induced significant cold and mechanical allodynia. Cold and mechanical allodynia were assessed by acetone drop and von Frey filament tests, respectively. Water extracts of <i>Z. officinale</i> (100, 300, and 500 mg/kg, p.o.) significantly attenuated both cold and mechanical allodynia induced by oxaliplatin. Intrathecal pre-treatment with the antagonist 5-HT<sub>1A</sub> (NAN-190, i.t., 1 μg), but not with the antagonist 5-HT<sub>2A</sub> (ketanserin, i.t., 1 μg), significantly blocked the analgesic effect of <i>Z. officinale</i> against both cold and mechanical allodynia. However, 5-HT<sub>3</sub> antagonist (MDL-72222, i.t., 15 μg) administration only blocked the anti-allodynic effect of <i>Z. officinale</i> against cold allodynia. Real-time PCR analysis demonstrated that <i>Z. officinale</i> significantly increased the mRNA expression of the spinal 5-HT<sub>1A</sub> receptor that was downregulated after oxaliplatin injection. These results suggest that <i>Z. officinale</i> may be a viable treatment option for oxaliplatin-induced neuropathic pain. |
| first_indexed | 2024-03-09T04:02:57Z |
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| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T04:02:57Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d13e5ed9f27b4343875c3d26e756a29a2023-12-03T14:10:49ZengMDPI AGMolecules1420-30492021-01-0126354810.3390/molecules26030548<i>Zingiber officinale</i> Roscoe Rhizomes Attenuate Oxaliplatin-Induced Neuropathic Pain in MiceJi Hwan Lee0Daeun Min1Donghun Lee2Woojin Kim3Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02453, KoreaDepartment of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02453, KoreaDepartment of Herbal Pharmacology, College of Korean Medicine, Gachon University, Gyeonggi-do 13120, KoreaDepartment of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02453, KoreaOxaliplatin is a platinum derivative chemotherapeutic drug widely used against cancers, but even a single treatment can induce a severe allodynia that requires treatment interruption and dose diminution. The rhizome of <i>Zingiber officinale</i> roscoe (<i>Z. officinale</i>, ginger), has been widely used in traditional medicine to treat various diseases causing pain; however, its effect against oxaliplatin-induced neuropathic pain has never been assessed. In mice, a single oxaliplatin (6 mg/kg, i.p.) treatment induced significant cold and mechanical allodynia. Cold and mechanical allodynia were assessed by acetone drop and von Frey filament tests, respectively. Water extracts of <i>Z. officinale</i> (100, 300, and 500 mg/kg, p.o.) significantly attenuated both cold and mechanical allodynia induced by oxaliplatin. Intrathecal pre-treatment with the antagonist 5-HT<sub>1A</sub> (NAN-190, i.t., 1 μg), but not with the antagonist 5-HT<sub>2A</sub> (ketanserin, i.t., 1 μg), significantly blocked the analgesic effect of <i>Z. officinale</i> against both cold and mechanical allodynia. However, 5-HT<sub>3</sub> antagonist (MDL-72222, i.t., 15 μg) administration only blocked the anti-allodynic effect of <i>Z. officinale</i> against cold allodynia. Real-time PCR analysis demonstrated that <i>Z. officinale</i> significantly increased the mRNA expression of the spinal 5-HT<sub>1A</sub> receptor that was downregulated after oxaliplatin injection. These results suggest that <i>Z. officinale</i> may be a viable treatment option for oxaliplatin-induced neuropathic pain.https://www.mdpi.com/1420-3049/26/3/548allodyniachemotherapy-induced neuropathic painoxaliplatinserotonin<i>Zingiber officinale</i> |
| spellingShingle | Ji Hwan Lee Daeun Min Donghun Lee Woojin Kim <i>Zingiber officinale</i> Roscoe Rhizomes Attenuate Oxaliplatin-Induced Neuropathic Pain in Mice Molecules allodynia chemotherapy-induced neuropathic pain oxaliplatin serotonin <i>Zingiber officinale</i> |
| title | <i>Zingiber officinale</i> Roscoe Rhizomes Attenuate Oxaliplatin-Induced Neuropathic Pain in Mice |
| title_full | <i>Zingiber officinale</i> Roscoe Rhizomes Attenuate Oxaliplatin-Induced Neuropathic Pain in Mice |
| title_fullStr | <i>Zingiber officinale</i> Roscoe Rhizomes Attenuate Oxaliplatin-Induced Neuropathic Pain in Mice |
| title_full_unstemmed | <i>Zingiber officinale</i> Roscoe Rhizomes Attenuate Oxaliplatin-Induced Neuropathic Pain in Mice |
| title_short | <i>Zingiber officinale</i> Roscoe Rhizomes Attenuate Oxaliplatin-Induced Neuropathic Pain in Mice |
| title_sort | i zingiber officinale i roscoe rhizomes attenuate oxaliplatin induced neuropathic pain in mice |
| topic | allodynia chemotherapy-induced neuropathic pain oxaliplatin serotonin <i>Zingiber officinale</i> |
| url | https://www.mdpi.com/1420-3049/26/3/548 |
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