Pediatric thalassemic patients have higher incidence of asthma: A nationwide population-based retrospective cohort study
<h4>Introduction</h4> Patients with hemoglobinopathies have been reported to have higher rates of pulmonary complications. Few studies have investigated the association between thalassemia and asthma in children. <h4>Methods</h4> We used the data of one million individuals ra...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568177/?tool=EBI |
| _version_ | 1818928772579065856 |
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| author | Hsin-Yi Hsieh Lin-Chi Huang Hong-Ren Yu Kuang-Che Kuo Wan-Hsuan Chen Chung-Hao Su Chuan-Pin Lee Ko-Jung Chen Yao-Hsu Yang Jiunn-Ming Sheen |
| author_facet | Hsin-Yi Hsieh Lin-Chi Huang Hong-Ren Yu Kuang-Che Kuo Wan-Hsuan Chen Chung-Hao Su Chuan-Pin Lee Ko-Jung Chen Yao-Hsu Yang Jiunn-Ming Sheen |
| author_sort | Hsin-Yi Hsieh |
| collection | DOAJ |
| description | <h4>Introduction</h4> Patients with hemoglobinopathies have been reported to have higher rates of pulmonary complications. Few studies have investigated the association between thalassemia and asthma in children. <h4>Methods</h4> We used the data of one million individuals randomly selected from the Registry for Beneficiaries of the National Health Insurance Research Database. One thalassemic child was matched with four control children without thalassemia according to sex, birth year, birth season, prematurity, and previous enteroviral infection. <h4>Results</h4> A total of 800 hundred thalassemic children and 3200 controls were included. Children with thalassemia had higher rates of developing asthma (41.81 vs 25.70 per 1000 person-years, P < 0.001) than the non-thalassemia controls with an adjusted hazard ratio of 1.37 (95% confidence interval [CI] = 1.19–1.58). Boys in the thalassemia cohort had a significantly higher adjusted incidence hazard ratio (IRR) of asthma than those in the non-thalassemia cohort (adjusted IRR = 1.45, 95% CI = 1.02–1.73). The risk of atopic and nonatopic asthma was higher in the thalassemia cohort than in the non-thalassemia cohort (IRR = 1.3, 1.61, respectively). <h4>Conclusions</h4> Children with thalassemia were more likely to develop asthma. More attention should be paid to the early diagnosis of asthma and prevention of asthma attacks. |
| first_indexed | 2024-12-20T03:34:13Z |
| format | Article |
| id | doaj.art-d13f61f1751543469ba89bcb9ed94fc7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T03:34:13Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d13f61f1751543469ba89bcb9ed94fc72022-12-21T19:54:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011611Pediatric thalassemic patients have higher incidence of asthma: A nationwide population-based retrospective cohort studyHsin-Yi HsiehLin-Chi HuangHong-Ren YuKuang-Che KuoWan-Hsuan ChenChung-Hao SuChuan-Pin LeeKo-Jung ChenYao-Hsu YangJiunn-Ming Sheen<h4>Introduction</h4> Patients with hemoglobinopathies have been reported to have higher rates of pulmonary complications. Few studies have investigated the association between thalassemia and asthma in children. <h4>Methods</h4> We used the data of one million individuals randomly selected from the Registry for Beneficiaries of the National Health Insurance Research Database. One thalassemic child was matched with four control children without thalassemia according to sex, birth year, birth season, prematurity, and previous enteroviral infection. <h4>Results</h4> A total of 800 hundred thalassemic children and 3200 controls were included. Children with thalassemia had higher rates of developing asthma (41.81 vs 25.70 per 1000 person-years, P < 0.001) than the non-thalassemia controls with an adjusted hazard ratio of 1.37 (95% confidence interval [CI] = 1.19–1.58). Boys in the thalassemia cohort had a significantly higher adjusted incidence hazard ratio (IRR) of asthma than those in the non-thalassemia cohort (adjusted IRR = 1.45, 95% CI = 1.02–1.73). The risk of atopic and nonatopic asthma was higher in the thalassemia cohort than in the non-thalassemia cohort (IRR = 1.3, 1.61, respectively). <h4>Conclusions</h4> Children with thalassemia were more likely to develop asthma. More attention should be paid to the early diagnosis of asthma and prevention of asthma attacks.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568177/?tool=EBI |
| spellingShingle | Hsin-Yi Hsieh Lin-Chi Huang Hong-Ren Yu Kuang-Che Kuo Wan-Hsuan Chen Chung-Hao Su Chuan-Pin Lee Ko-Jung Chen Yao-Hsu Yang Jiunn-Ming Sheen Pediatric thalassemic patients have higher incidence of asthma: A nationwide population-based retrospective cohort study PLoS ONE |
| title | Pediatric thalassemic patients have higher incidence of asthma: A nationwide population-based retrospective cohort study |
| title_full | Pediatric thalassemic patients have higher incidence of asthma: A nationwide population-based retrospective cohort study |
| title_fullStr | Pediatric thalassemic patients have higher incidence of asthma: A nationwide population-based retrospective cohort study |
| title_full_unstemmed | Pediatric thalassemic patients have higher incidence of asthma: A nationwide population-based retrospective cohort study |
| title_short | Pediatric thalassemic patients have higher incidence of asthma: A nationwide population-based retrospective cohort study |
| title_sort | pediatric thalassemic patients have higher incidence of asthma a nationwide population based retrospective cohort study |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568177/?tool=EBI |
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