Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice

Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice

ARHGEF6 belongs to the family of guanine nucleotide exchange factors (GEFs) for Rho GTPases, and it specifically activates Rho GTPases CDC42 and RAC1. Arhgef6 is the X-linked intellectual disability gene also known as XLID46, and clinical features of patients carrying Arhgef6 mutations include intel...

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Bibliografiska uppgifter
Huvudupphovsmän: Chengwen Zhu, Cheng Cheng, Yanfei Wang, Waqas Muhammad, Shuang Liu, Weijie Zhu, Buwei Shao, Zhong Zhang, Xiaoqian Yan, Qingqing He, Zhengrong Xu, Chenjie Yu, Xiaoyun Qian, Ling Lu, Shasha Zhang, Yuan Zhang, Wei Xiong, Xia Gao, Zhigang Xu, Renjie Chai
Materialtyp: Artikel
Språk:English
Publicerad: Frontiers Media S.A. 2018-10-01
Serie:Frontiers in Molecular Neuroscience
Ämnen:
Arhgef6
hair cells
stereocilia
sensorineural hearing loss
guanine nucleotide exchange factors
Länkar:https://www.frontiersin.org/article/10.3389/fnmol.2018.00362/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00362/full

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