Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice

Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice

ARHGEF6 belongs to the family of guanine nucleotide exchange factors (GEFs) for Rho GTPases, and it specifically activates Rho GTPases CDC42 and RAC1. Arhgef6 is the X-linked intellectual disability gene also known as XLID46, and clinical features of patients carrying Arhgef6 mutations include intel...

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Príomhchruthaitheoirí:	Chengwen Zhu, Cheng Cheng, Yanfei Wang, Waqas Muhammad, Shuang Liu, Weijie Zhu, Buwei Shao, Zhong Zhang, Xiaoqian Yan, Qingqing He, Zhengrong Xu, Chenjie Yu, Xiaoyun Qian, Ling Lu, Shasha Zhang, Yuan Zhang, Wei Xiong, Xia Gao, Zhigang Xu, Renjie Chai
Formáid:	Alt
Teanga:	English
Foilsithe / Cruthaithe:	Frontiers Media S.A. 2018-10-01
Sraith:	Frontiers in Molecular Neuroscience
Ábhair:	Arhgef6 hair cells stereocilia sensorineural hearing loss guanine nucleotide exchange factors
Rochtain ar líne:	https://www.frontiersin.org/article/10.3389/fnmol.2018.00362/full

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